Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Neurotrophins in Sensory Neuron Development
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:15 pm
"Neurotrophic Signaling and Development of Somatosensory Neurons"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 8:50 pm
"The Cellular Basis for Somatosensation and Pain"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:25 pm
"The Development and Functional Organization of Mammalian Somatosensory Neurons"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Neurotrophic Mechanisms in Brain Development
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Modeling Human Brain Development and Diseases Using Brain-Region Specific Organoids"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Growth Factor Control of Neural Stem Cells in Normal and Pathological Conditions"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
"How Nature and Nurture Conspire to Control Brain Development and Function"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
"A New Mouse Model to Understand the Functional Relevance of BDNF in the Blood Platelets of Primates"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"Interaction of Spatially Graded Chemical and Mechanical Cues in the Guidance of Brain Cells"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Inflammation and Neurodegeneration
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Convergence of Basic and Clinical Neuroscience: Familial Dysautonomia, Elongator, Neuronal Death and Neurotrophins?"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"BDNF Function in Neurons and Microglia Cells During Neuroinflammation"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 9:00 pm
"Creating Small Molecule Ligands for Neurotrophin Receptors to Treat Alzheimer's and Other Neurological Disorders"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
"Epigenetic Modulation of BDNF Signaling in Autism Spectrum Disorders"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Cell Biology of Plasticity
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Cellular and Molecular Mechanisms Linking Synaptic Specificity and Circuit Function"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Sonic Hedgehog Signaling Mediated Neuron-Astrocyte Crosstalk During Cortical Circuit Assembly"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
"Mechanisms Regulating the Long Distance Trafficking of Neurotrophic Factors in Neurons"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
"The Role of Insulin-Like Growth Factor 2 in Memory Formation and Enhancement"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"Neuronal Autophagy: Dynamics and Function"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Using Extreme Physiology to Discover Molecular Mechanisms of Pain to Hypoxia Resistance"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Sex, Pain and Microglia BDNF"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 9:00 pm
"Tanezumab Clinical Program Overview"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
"Monitoring Synaptic BDNF Secretion in a BDNF-GFP Knock-in Mouse"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Stress, Depression and Fear Regulation
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Mechanisms of Rapid Antidepressant Responses"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Neurotrophic Factors in Stress, Depression and Treatment Response: Remodeling Synaptic Connections"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
"Regulation of Synaptic Plasticity by BDNF-Endocannabinoid Interactions"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
"Impact of BDNF-TrkB Signaling on OCD-Like Behaviors"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Injury and Growth Control
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Single Cell Responses to Injury"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"The Secret Life of 3'UTRs in Axons"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 9:00 pm
"SpƤtzle3 Promotes Neuronal Survival and Function Through the Regulation of Glial Morphogenesis"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
"Neurotrophin-Mediated Regulation of Axonal Transport Is Perturbed in Genetic Peripheral Neuropathy"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Axon Pruning and Degeneration
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Mechanisms of Axonal Pruning"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Mechanisms of Axon Degeneration and Retrograde Death Signals"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
"Deciphering Trophic Rheostats Governing Peripheral Sensory Nervous System Development"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
"Axonal Survival Mechanisms"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"Peripheral Nerve Growth Factors and Tissue Regeneration "
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
p75NTR Biology and Pathophysiology
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Disrupted Cholesterol Metabolism in Schwann Cells Lacking the p75 Neurotrophin Receptor Causes Sensory Neuron Degeneration"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"p75NTR Regulates the Cell Cycle of Cerebellar Granule Cell Progenitors, Impacting Circuitry Development Leading to ASD-Like Behaviour"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 9:00 pm
"The Role of CD271/NGFR in Melanoma"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
"Shining Light on Dynamic TrkA Signaling"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure