Integrating Dynamics, Mechanisms and Consequences to Understand Notch Signaling Specificity and Disease Implications

July 21 - 22, 2018

Chairs Daniel Lafkas and Rachel K. LoPilato

Contact Chairs

Bates College

2 Andrews Road

Lewiston, ME, US

Venue and Travel Information

Conference Description

The Gordon Research Seminar on Notch Signaling in Development, Regeneration and Disease is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The focus of this meeting is how Notch signaling is regulated in different cellular contexts, including homeostasis, cancer and other diseases, and how it cross-talks with other signaling, metabolic and environmental cues. A particular emphasis will be put on the dynamics of activation and signaling as well as the control of the variability of downstream cellular responses.

Related Meeting

This GRS will be held in conjunction with the "Notch Signaling in Development, Regeneration and Disease" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
2:00 pm - 5:00 pm	Arrival and Check-in
3:30 pm - 3:45 pm	Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm	Keynote Session: Post-Translational Modifications in the Notch Signaling Pathway Discussion Leader: Daniel Lafkas (Genentech Inc., USA)
3:45 pm - 4:15 pm	Pamela Stanley (Albert Einstein College of Medicine, USA) "Roles of Glycosylation in Notch Signaling"
4:15 pm - 4:30 pm	Discussion
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Dynamic Control of Cell Fate and Function Discussion Leaders: Qi Yang (Albany Medical College, USA), Adrian Jacobo (Rockefeller University, USA) and ChangHwan Lee (University of Wisconsin-Madison / Howard Hughes Medical Institute, USA)
7:30 pm - 7:45 pm	Eric Perkey (University of Michigan, USA) "Specialized Fibroblasts in Secondary Lymphoid Organs Program Effector T Cell Responses Through Notch Signals in Graft-Versus-Host Disease and Other Immunological Contexts"
7:45 pm - 7:50 pm	Discussion
7:50 pm - 8:05 pm	Joshua Adams (Baylor College of Medicine, USA) "Sox9 Levels Determine the Severity and Progression of Liver Disease in a Mouse Model of Alagille Syndrome"
8:05 pm - 8:10 pm	Discussion
8:10 pm - 8:25 pm	Craig Jacobs (University of Calgary, Canada) "PHRESH Analysis Reveals a Role for Notch Signalling in the Maintenance of Hh Response During Spinal Cord Patterning"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:45 pm	Emilie Abby (Wellcome Trust Sanger Institute, United Kingdom) "Elucidating the Cellular and Molecular Effects of Notch1 Inactivating Mutations in the Oesophagus"
8:45 pm - 8:50 pm	Discussion
8:50 pm - 9:05 pm	Oscar Stassen (Eindhoven University of Technology, The Netherlands) "A Biomimetic Cardiovascular-Tissue-on-a-Chip to Study the Interplay Between Notch Signalling and Hemodynamic Loading"
9:05 pm - 9:10 pm	Discussion
9:10 pm - 9:25 pm	Roshana Thambyrajah (Fundació IMIM, Spain) "How Much Notch Is Enough for HSC Generation?"
9:25 pm - 9:30 pm	Discussion
Sunday
7:30 am - 8:30 am	Breakfast
9:00 am - 11:00 am	Structural Mechanics and Signaling Discussion Leaders: Vincent Luca (Moffitt Cancer Center & Research Institute, USA), David Sloas (Boston University, USA) and Anna Erzberger (The Rockefeller University, USA)
9:00 am - 9:15 am	Julia Falo-Sanjuan (University of Cambridge, United Kingdom) "Dynamics of Transcription from Notch-Responsive Enhancers"
9:15 am - 9:20 am	Discussion
9:20 am - 9:35 am	ChangHwan Lee (University of Wisconsin-Madison / Howard Hughes Medical Institute, USA) "Dynamics of Notch-Dependent Transcriptional Activation in Its Natural Context"
9:35 am - 9:40 am	Discussion
9:40 am - 9:55 am	Eleni Foteinou (University of Manchester, United Kingdom) "Classifying Mutant Outcomes Arising from Different EGF Domain Mutations Within the Ligand Binding Region of Notch"
9:55 am - 10:00 am	Discussion
10:00 am - 10:15 am	Giulia Monticone (University of Manchester, United Kingdom) "Cancer-Associated Mutations Affect Notch Endocytic Trafficking"
10:15 am - 10:20 am	Discussion
10:20 am - 10:35 am	Adrian Jacobo (Rockefeller University, USA) "Notch-Mediated Polarity Decisions in the Zebrafish's Lateral Line"
10:35 am - 10:40 am	Discussion
10:40 am - 10:55 am	Udi Binshtok (Tel Aviv University, Israel) "Cell-Cell Contact Area Affects Notch Signaling and Notch-Dependent Patterning"
10:55 am - 11:00 am	Discussion
11:00 am - 12:30 pm	Poster Session Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm	Lunch
1:30 pm - 2:30 pm	Mentorship Component: From Surviving to Thriving in Research Discussion Leader: Rachel LoPilato (University of Georgia, USA)
1:30 pm - 2:30 pm	Panel Discussion From Surviving to Thriving in Research Vincent Luca (Moffitt Cancer Center & Research Institute, USA) David Sprinzak (Tel Aviv University, Israel) Qi Yang (Albany Medical College, USA)
2:30 pm - 3:00 pm	Evaluation Period Fill in GRS Evaluation Forms
3:00 pm	Seminar Concludes

Contributors

Research reported in this publication was supported by the Eunice Kennedy Shriver National Institute of Child Health & Human Development of the Nation Institutes of Health under Award Number R13HD095611. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Conference Links

Conference History Notch Signaling in Development, Regeneration and Disease

Registration Fees Additional Fee Info

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