Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Genomic Engineering and Regulation
The keynote speaker is Professor Jennifer Doudna (HHMI / UC Berkeley).
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:35 pm
"RNA-Guided Immunity: CRISPR Biology and the Future of Genome Engineering"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Genome Integrity
and DNA Repair
9:00 am - 9:20 am
"The DNA Damage Response in Cancer Treatments"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"SMX and GEN1 Endonucleases Resolve Sister Chromatid Bridges to Ensure Chromosome Segregation"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"DNA Sculpting and the Specificity of DNA Repair Machines"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Base Excision Repair of DNA Interstrand Crosslinks"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Activation of a DNA Mismatch Repair Endonuclease that Acts in Meiotic Crossing Over"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Mechanism of Homologous Recombination and Crossover Control"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Changing the Transcriptome: RNA Editing and Modification
7:30 pm - 7:50 pm
"ADARs, Dicer and the dsRNAome"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"RNA Methylation in Gene Expression Regulation"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Translation Regulation by Dynamic mRNA Methylation"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"Taking RNA in a New Direction: 3'-5' Polymerases in Biology"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Heme-Mediated Regulation of microRNA Processing"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
DNA Replication and Transcription
9:00 am - 9:20 am
"Structural Mechanisms of Nucleic-Acid Dependent Machines"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Opening and Closing the Mcm2-7 Ring During Origin Licensing"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"The Bacterial Replisome Caught in the Act by Cryo-EM"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"RecQ4 - The Odd One out in the RecQ Helicase Family"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Structural Mechanisms of Swi2/Snf2 Remodelling Enzymes"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Mechanistic Insights into Eukaryotic Transcription Initiation from Cryo-EM Studies"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Regulation of Translation: Starts, Stops, and Pauses
7:30 pm - 7:50 pm
"Molecular Mechanism of Scanning and Start Codon Selection in Translation Initiation"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Human eIF3: The Mediator of Translation"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Visualization of Translation by Ensemble Cryo-EM"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"Adjacent Codons Act in Concert to Modulate Translation"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Structural Basis of Co-Translational Quality Control"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Noncoding RNAs (ncRNAs) and Defense Mechanisms
9:00 am - 9:20 am
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Structure-Based Discovery of New Functions in Large RNAs"
9:50 am - 10:00 am
Discussion
10:00 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
"Molecular Architecture of Long Noncoding RNAs"
11:00 am - 11:10 am
Discussion
11:10 am - 11:20 am
"Methyltransferase-Like Protein 16 Binds the 3'-Terminal Triple Helix of MALAT1 Long Noncoding RNA"
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
"Developmental and Physiological Function of circRNAs"
11:35 am - 11:40 am
Discussion
11:40 am - 12:00 pm
"Mechanisms of tRNA Splicing and tRNA Repair"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
7:30 pm - 7:50 pm
"Telomerase and Maintenance of Telomere Length Equilibrium"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Integrative Structural Biology of Telomerase"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Telomerase Innovations for Telomeric Repeat Synthesis"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Pif1 Family Helicases: Maestros at Bypassing Hard-to-Replicate Sites"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Eukaryotic Replication Fork
9:00 am - 9:20 am
"Structure and Mechanism of the Eukaryotic Replication Fork"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Reconstitution of Eukaryotic Chromosome Replication with Purified Proteins"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Dynamic Interactions at the Eukaryotic Replication Fork"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"rNTP Incorporation During Nuclear DNA Replication in Yeast and Its Consequences"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Nucleotide Pools Dictate the Identity and Frequency of Ribonucleotide Incorporation in Mitochondrial DNA"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Activities of ssDNA Binding Proteins in Maintaining Replication Fork Stability"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Conflict Between CRISPR Interference and DNA Replication as a Trigger for CRISPR Adaptation"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Gene Expression and Regulation in Disease
7:30 pm - 7:55 pm
"RNA Quality Control by the Nuclear RNA Exosome"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:15 pm
"Dense Mutational Interrogation to Untangle Functions of Factors Comprising a Complex Essential System, the Human RNA Exosome"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:30 pm
"Chemical and Structural Bias in Small:Molecule RNA Recognition"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:45 pm
"LARP1 Regulates Translation of the Translation Apparatus"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
"mRNA Splicing and Disease"
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure