Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Telomeres and the DNA Damage Response
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:50 pm
"Telomeres and the DNA Damage Response"
8:50 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Nucleic Acids in Immunity
9:00 am - 9:20 am
"The cGAS-STING Pathway of Cytosolic DNA Sensing and Signaling"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Structural and Mechanistic Insights into RNA-Guided CRISPR Immunity"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Divergent Roles of Dicer's Helicase Domain in Antiviral Defense"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Designing Potent RNA Agonists for Activating the RIG-I Receptor"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Combating Cancer and Clots with RNA-Based and RNA-Targeted Therapeutics"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Viral and Metazoan Poxins Are cGAMP-Specific Nucleases that Restrict cGAS-STING Signaling"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Ubiquitin-Dependent and -Independent Roles of E3 Ligase RIPLET in Innate Immunity"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Ribosome Assembly and Function
7:30 pm - 7:50 pm
"Nucleolar Stages of Eukaryotic Ribosome Assembly"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Variant Ribosomal RNA Alleles Are Conserved, Exhibit Context-Specific Expression and Regulate Gene Expression"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Chemical Damage and Ribosome-Based Quality-Control Processes"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Cas9-Induced DNA Double-Strand Breaks Trigger Ribosome Remodeling and Translational Shutdown"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Transcriptional Regulation and Coupling to RNA Fate
9:00 am - 9:20 am
"Differential Regulation of Transcriptional Elongation and RNA Processing at Non-Coding RNA Loci"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Single Molecule and Modeling Approaches Reveal Principles of R-Loop Formation"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
"Mechanistic Insights into the Eukaryotic mRNA Poly(A) Tail Machinery"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
"How Splicing Regulation Is Coupled to Transcription"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Swr1 and INO80 Complexes: Chromatin Modifying Machines"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Coordination of Transcription and DNA Replication in C. elegans "
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Organization of the Genome in Three Dimensions and Dynamic Genome Rearrangements
7:30 pm - 7:50 pm
"Genome Organization by SMC Protein Complexes"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Structural Insights into DNA Pairing and Cleavage by RAG1/2"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Mobile Element Replication-Related Machinery: What Does It Do and Why?"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"P Element Transposons in Drosophila and Vertebrates"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Genome Integrity: Replication and Recombination
9:00 am - 9:20 am
"Dynamic Quality Control and Pathway Reversibility During Homologous Recombination"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Enforcement of DNA Ligation Fidelity"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
"Recruitment of Human Telomerase to Telomeres"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
"Replenishing the Ends: Structural Mechanism of Human Telomerase"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Mechanisms for Initiating DNA Replication"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Genome Instability Caused by Persistent RNA-DNA Hybrid Formation"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Genome Integrity: Damage Recognition, Avoidance and Repair
7:30 pm - 7:50 pm
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"ADP-Ribosylation Signaling in Regulation of Genome Stability"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Structural Insights into DNA Repair at Stalled Replication Forks"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Functional Significance of Conformational Flexibility in DNA Repair Enzymes"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:20 am
"NAD+ in the Control of RNA Turnover"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Transcriptional Coactivator PGC-1alpha Contains a Novel CBP80-Binding Motif that Orchestrates Efficient Target Gene Expression"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Nuclear Quality Control: Cofactors of the RNA Exosome"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"A New Pathway of Pre-tRNA Surveillance"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"An Orphan 3'-5' Polymerase Implicated in Noncoding RNA Processing"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Active Site Coordination Within a Multienzyme Pre-rRNA Processing Complex"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"PTBP1 Promotes ATPase-Dependent Dissociation of UPF1 from mRNPs to Prevent Nonsense Mediated Decay"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Replication Protein A: Interplay Between the DNA Binding Domains and Its Functional Significance"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Biological and Therapeutic Impact of Nucleic Acid Modifications
5:30 pm - 5:50 pm
"Temporal and Spatial Dynamics of High-Level mRNA Editing in Cephalopods"
5:50 pm - 6:00 pm
Discussion
6:00 pm - 6:20 pm
"Circular RNAs and Other Unexpected Outputs of Protein-Coding Genes"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
"Transcriptome-Wide Mapping and Functional Study of N3-Methylcytosine Methylome in Polyadenylated RNA"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 6:55 pm
"mRNA Modifications Alter Translation Elongation and Fidelity"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
"Structural Basis of 7SK RNA 5'-Gamma-Phosphate Methylation and Retention by MePCE"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
"Molecular Basis of Microhomology-Mediated End-Joining by Purified Full-Length Pol-Theta"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure