1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Frontiers of Nucleic Acid Therapaeutics
Susan Liao (New York University, United States)
3:45 pm - 3:55 pm
Tianshuo Liu (Yale University, United States) "Development of Novel Antifungals Targeting Tertiary Structured Riboregulatory Elements"
3:55 pm - 4:00 pm
4:00 pm - 4:10 pm
Elizabeth Tidwell (University of Michigan, United States) "High Throughput Screening of Small Molecule Binding Partners for the FMN Riboswitch by a Multidisciplinary Approach"
4:10 pm - 4:15 pm
4:15 pm - 4:25 pm
Max Wilkinson (Broad Institute of Harvard and MIT, United States) "Structure of the R2 non-LTR Retrotransposon Initiating Target-Primed Reverse Transcription"
4:25 pm - 4:30 pm
4:30 pm - 6:00 pm
6:00 pm - 7:00 pm
7:30 pm - 9:30 pm
Technological Advancements in Understanding Nucleic Acid Biology
Rebecca Roddan (University of Oxford, United Kingdom)
7:30 pm - 7:40 pm
Akanksha Manghrani (Duke University, United States) "Probing Hoogsteen base-pairs in vitro and in cells"
7:40 pm - 7:45 pm
7:45 pm - 7:55 pm
Luiz Passalacqua (NHLBI - NIH, United States) "Structural Basis for Fluorophore Activation by a DNA Mimic of Green Fluorescent Protein"
7:55 pm - 8:00 pm
8:00 pm - 8:10 pm
Jesse Pyle (New England Biolabs, United States) "Novel Cytosine Hypermodifications by Diverse Bacteriophage Glycosyltransferases"
8:10 pm - 8:15 pm
8:15 pm - 8:25 pm
Pulak Ghosh (Indian Institute of Science Education and Research (IISER), Pune, India) "Probing the Chemical Space Tolerance and Processivity of DNA Polymerases in real time and 3D Using Responsive Fluorescent Nucleotide Analogs"
8:25 pm - 8:30 pm
8:30 pm - 8:40 pm
David Qiu (UNC Chapel Hill, United States) "High Throughput RNA Tertiary Structure Discovery by Chemical Probing"
8:40 pm - 8:45 pm
8:45 pm - 8:55 pm
Susan Liao (New York University, United States) "Interpretable Machine Learning to Decipher Splicing Regulatory Logic"
8:55 pm - 9:00 pm
9:00 pm - 9:10 pm
Sarah Strassler (Emory University, United States) "tRNA m1G9 Modification Depends on Substrate-Specific RNA Conformational Changes Induced by the Methyltransferase Trm10"
9:10 pm - 9:15 pm
9:15 pm - 9:25 pm
Seth Veenbaas (UNC - Chapel Hill, United States) "Ligand-Binding Pockets in RNA and Where to find them"
9:25 pm - 9:30 pm
7:30 am - 8:30 am
9:00 am - 11:00 am
Mechanisms of Gene Expression Regulation
Suparno Nandi (Emory University, United States)
9:00 am - 9:10 am
Ling Xu (Yale University, United States) "Group II Intron Splicing Mechanisms - Ribozymes and Retrotransposons"
9:10 am - 9:15 am
9:15 am - 9:25 am
Rebecca Roddan (University of Oxford, United Kingdom) "The Molecular Basis of DNA Interstrand Crosslink Resection During Transcription-Coupled Repair"
9:25 am - 9:30 am
9:30 am - 9:40 am
Carmen Grandi ( Radboud University, The Netherlands) "Decoupled Transcription and Translation Enables Noise-Modulation by Poly(A)-Tails"
9:40 am - 9:45 am
9:45 am - 9:55 am
David Beier (University of Michigan, United States) "Turning Up the Heat: The Dynamic Role of the prfA RNA Thermosensor in Translation Regulation"
9:55 am - 10:00 am
10:00 am - 10:10 am
Natalie Popielski (State University of New York at Buffalo, United States) "Evidence Supporting a Distinct Model for Activity of Mutagenic DNA Polymerase ImuC in Pseudomonas Aeruginosa"
10:10 am - 10:15 am
10:15 am - 10:25 am
Urmimala Basu (Harvard Medical School, United States) "Characterizing the role of the Yeast cap Methyltransferase Abd1 in Transcription Regulation"
10:25 am - 10:30 am
10:30 am - 10:40 am
Praneeth Bommisetti (Graduate Student, United States) "Insights into the Mechanism of Installation of the 5-Carboxymethylaminomethyl Group onto Wobble Uridines by tRNA Modifying Enzymes MnmE and MnmG"
10:40 am - 10:45 am
10:45 am - 10:55 am
Syed Usman Enam (Stanford University School of Medicine, United States) "Weird Bases in Weird Places: A Molecular Metagenomic Screen Reveals Genomes with Non-Canonical Bases"
10:55 am - 11:00 am
11:00 am - 12:30 pm
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
1:30 pm - 2:30 pm
Mentorship Component: Scientific Journey: Graduate School and Beyond
Urmimala Basu (Harvard Medical School, United States)
1:30 pm - 1:35 pm
Introduction by Discussion Leader
1:35 pm - 2:30 pm
Scientific Journey:Graduate School and Beyond
Raghav Poudyal (Orbital Therapeutics, United States)
Yamuna Krishnan (University of Chicago, United States)
Muthiah (Mano) Manoharan (Alnylam Pharmaceuticals, United States)
2:30 pm - 3:00 pm
Complete the GRS Evaluation Forms; Election of Future Chair(s)