Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Chemistry on the Genome
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:00 pm
"Gene-Repair at the Endogenous Level Using PolyPurine Reverse Hoogsteen Hairpins (PPRHs) in Mammalian Cells"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:15 pm
"Nanoparticle Delivered Next Generation Gamma PNAs for Minimally Invasive Gene Editing"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 9:10 pm
"Base Editing: Genome Editing Without Double-Stranded DNA Cleavage"
9:10 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Writing, Reading and Erasing DNA Modifications
9:00 am - 9:30 am
"Transition State Mimics for BER Glycosylases to Decipher Mechanisms and Create New Chemical Biology Tools"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Epigenetic Instability Induced by Structured DNA"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Insight into DNA 5-Methylcytosine Oxidation by the Mouse Ten-Eleven Translocation 2 (mTET2)
Enzyme"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
"Dynamic Alkylation of DNA"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Catalytic Plasticity of DNA Methyltransferases: Can Writers Be Erasers?"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Nucleotides and Dinucleotides
7:30 pm - 7:55 pm
"ZRANB3 Dynamically Regulates DNA Synthesis Rate in Response to dATP Signaling"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Riboswitching on the Light: Imaging Cyclic Dinucleotides Involved in Bacterial and Immune Signaling"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"2',3'-cNMPs in Bacteria: Metabolism and Cellular Roles"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Towards Nucleoside-Derived Antibiotics: Inhibitors of the Bacterial Translocase MraY"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Alternative Bases and Backbones
9:00 am - 9:30 am
"Structure-Guided Control of siRNA Properties"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"PNA-Programmed Assemblies"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Backbone-Branched and Mini-Lariat RNA: Synthesis, Debranching and RNA Interference"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
"Phosphorothioate and 7-Deazaguanine DNA Modifications as the Nose of a Hippopotamus: The Burgeoning Field of Prokaryotic and Viral Epigenetics"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Self-Neutralizing Oligonucleotides with Enhanced Unassisted Cellular Uptake"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:55 pm
"Modulating Nucleic Acid Structure and Function Using Shape-Selective Small Molecules"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Structure and Function of Catalytic DNA"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"DNAzymes, Photons, and Heme"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Effects of 8-Oxo-7,8-Dihydropurines on RNA Structure and Function Using Aptamers as Models and Their Reactivity Towards RNase T1, A, and H"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Antiviral and Antimicrobial Strategies
9:00 am - 9:30 am
"Mitochondrial Toxicity and Antiviral Nucleoside Inhibitors"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Engineering the Aminohexose-Cytosine Antibiotics as Selective P-Site Inhibitors"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Presence, Function and Targeting of G-Quadruplexes in Viral Genomes"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
"HIV Hates U: Viral Restriction and Mutagenesis by Host Uracil Base Excision Repair"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Structure-Activity Relationship Analysis of Mitochondrial Toxicity Caused by Antiviral Ribonucleoside Analogs"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
New Insights into Polymerases
7:30 pm - 7:55 pm
"A New Mechanistic Class of Antiviral Ribonucleoside Discovered by Using Magnetic Tweezers to Monitor Activity of a Viral Polymerase"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"3'-5' Polymerases in Biology: Non-Canonical Mechanisms of RNA Editing and Processing"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Probing DNA and RNA Polymerases with Novel Deazapurine Analogs"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"A Sequence-Specific Fluorescence Turn-on Nucleoside Analogue"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Targeting Riboswitches, tRNA and the Ribosome
9:00 am - 9:30 am
"Structure of a Riboswitch that Responds to Guanidine"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Selective Small Molecule Inhibition of an RNA Structural Element"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Impact of Modified Nucleotides on rRNA Structure and Ligand Binding"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
"Immucillins as Drug Candidates"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"In-Cell Activation of siRNA Using Bio-Orthogonal Chemistry"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Imaging of/by Nucleic Acid Components
7:30 pm - 7:55 pm
"Molecular DNA Devices for Cell-Specific Cargo Delivery In Vivo "
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"A Bioorthogonal Chemical Reporter of Nucleoside Drug Resistance"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Chemical Biology of Nucleic Acids: DNA Origami and Artificial Genetic Switch"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Peptide Nucleic Acids (PNAs) as Diagnostic Molecules for the Early Detection of Cancer"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure