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Nucleosides, Nucleotides and Oligonucleotides (GRS)

Gordon Research Seminar

Advancing Nucleic Acid and Nucleoside Therapeutics Through Strategic Chemistry and Chemical Biology

July 5 - 6, 2025
Chairs and
Salve Regina University
36 Ochre Point Avenue
Newport, Rhode Island, United States
 Venue and Travel Information

Conference Description

The Nucleosides, Nucleotides and Oligonucleotides GRS provides a unique forum for young doctoral and post-doctoral researchers to present their work, discuss new methods, cutting edge ideas, and pre-published data, as well as to build collaborative relationships with their peers. Experienced mentors and trainee moderators will facilitate active participation in scientific discussion to allow all attendees to be engaged participants rather than spectators.

The 2025 GRS will focus on the latest advances and challenges in the burgeoning field of nucleosides, nucleotides and oligonucleotides. Scientific sessions will cover topics such as novel oligonucleotide synthetic strategies, discovery and development of nucleosides and oligonucleotides therapeutics, molecular recognition of DNA and RNA, new chemical biology and structural tools for nucleic acids, as well as advancements in genome editing and targeted gene therapy. The scientific program will feature three themed sessions, including a keynote lecture and a mentorship panel comprised of diverse representatives from academia and industry, focusing on career development and professional growth.

Related Meeting

This GRS will be held in conjunction with the "Nucleosides, Nucleotides and Oligonucleotides" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Keynote Session: Mechanism-Based Improvements to RNA Synthesis/Manufacturing by T7 RNA Polymerase
Discussion Leader:
3:45 pm - 3:50 pm
Introduction by Discussion Leader
3:50 pm - 4:20 pm
"Novel Mechanism-based Improvements to RNA Synthesis/Manufacturing by T7 RNA Polymerase"
4:20 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Chemistries for Enhancing the Efficacy of Nucleic Acid Therapeutics
Discussion Leader:
7:30 pm - 7:45 pm
"Synthesis of Modified Nucleotides via Engineered Biocatalytic Enzymes"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
"Difluorinated Nucleosides: Expanding the Functional Repertoire of Therapeutic Oligonucleotides"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Synthesis of Modified Nucleotides for Self-Amplifying RNA Applications: Electrochemical Installation of Fluorinated Motifs on Purines and Pyrimidines"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Fluorine-Modified CRISPR-Cas12a crRNA for Gene Editing"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Enhancing Cap-Independent Translation of Linear mRNA"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"De-Repressing the 3’UTR with Steric Blocking Oligonucleotides Activates STXBP1"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Utilizing Nucleic Acid Chemical Biology for Advanced Probing, Sensing and Modifications
Discussion Leader:
9:00 am - 9:15 am
"5-Triazolyl Uridine Improves Nucleobase Stacking and Pyrimidine Recognition in RNA-Binding Triplex-Forming Peptide Nucleic Acids"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
"Live-Cell Assay for the Detection of eIF4E-m7G RNA-Protein Interactions"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
"The Shape of Control: How Going in Circles Keeps RNA Catalytically Switched On"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
"Two-Dye Ratiometric, Single-Dye Ratiometric, and Mirror-Image RNA-Based Sensors for Imaging Glycine in Live Cells"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
"FluoroDetect – A Novel Biosensor for Determination of RNA Interference"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
"Fluorescent Probes for the Detection of Adenosine Methylation in DNA and RNA"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Exploring Career Paths: Perspectives from Academia, Industry, and Start-Ups
Discussion Leader:
1:30 pm - 1:35 pm
Introduction by Discussion Leader
1:35 pm - 2:30 pm
Panel Discussion
Exploring Career Paths: Perspectives from Academia, Industry, and Start-Ups
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes

Research reported in this publication was supported by the National Center For Advancing Translational Sciences of the National Institutes of Health under Award Number R13TR005695. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Conference Links

Conference History Nucleosides, Nucleotides and Oligonucleotides
Additional Fee Info



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