Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Channels and Metabolite Transporters in Chloroplasts
This session will focus on the link between ion/metabolite transport and the regulation of chloroplast function.
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:15 pm
"Thylakoid K+ and Cl- Channels and Transporters Regulate Photosynthesis in Fluctuating Light"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"The Transporter PAM71, Crucial for Manganese Delivery to Maintain Optimal Photosynthesis, Is Present in Plants and in Humans"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"The K+ /Na+ Interplay in Arabidopsis kea1kea2 Mutants - New Insights into Cellular and Subcellular Ion Homeostasis"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"What Drives Ion Transport Across the Thylakoid Membrane?"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Solute Transport and Signaling in Mitochondria from Animals and Plants
This session addresses outstanding questions in mitochondrial physiology.
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"Mitochondrial Regulation of Mitochondrial Potassium Channels"
9:35 am - 9:40 am
Discussion
9:40 am - 10:05 am
"New Turns on Fundamental Metabolism: Regulation of Cori Cycle Dynamics by the Mitochondrial Pyruvate Carrier"
10:05 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
"Safety Upgrade of the Mitochondrial Calcium Uniporter Complex"
11:05 am - 11:10 am
Discussion
11:10 am - 11:35 am
"Mitochondrial ATP-Sensitive Potassium Channels (mitoKATP): Molecular Identity and Physiological Role"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
"VDAC2-BAK Axis Regulates Peroxisomal Membrane Permeability and Catalase Release"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"SK Channels Prevent Neurotoxicity in Conditions of Enhanced ER Mitochondrial Coupling"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Malate Transport in Mitochondria Is Regulated Diurnally by Two Dicarboxylate Carriers in Arabidopsis "
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Emerging Methodologies: Unraveling Intracellular Fluxes with Novel Specific Probes
Innovative approaches to detect ion and metabolites fluxes across intracellular membranes in vivo .
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
"Intracellular Sites of Trace Metal Accumulation in Eukaryotes"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"In Vivo Calcium Dynamics in Plant Cells: A Holistic View"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 8:55 pm
"Novel Local RyR1 Junctional Calcium Responses and Dynamics by Improved Calcium Sensor CatchER"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Secretory Granule Protein Chromogranin B Forms a Novel Chloride Channel in Membrane"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Optically Recording of Intracellular Zinc Release from Lysosomes"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Channels/Transporters in Exo/Endo-Cytosis Pathways
This session covers vesicular and lysosomal ion channels with special emphasis on pathological links.
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"How to Fill a Vesicle in 30 Seconds? Uptake Mechanisms for Amino Acid Neurotransmitters"
9:35 am - 9:40 am
Discussion
9:40 am - 10:05 am
10:05 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
"Protons to Patients: Evaluating the Role of the Chloride Transporter ClC-7 in Lysosomal Function"
11:05 am - 11:10 am
Discussion
11:10 am - 11:25 am
"Identification of OCaR1 as a Gatekeeper of Lysosomal-Granular Ca2+ Release and Regulated Exocytosis"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
"TM9SF4 Is a Novel Organelle Potassium Channel Crucial for Starvation-Induced Autophagy in Mammalian Cells"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Acidification Mechanisms in Intracellular Organelles"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Mechanism of Fatty Acid Transport by the Peroxisomal ABC Transporter COMATOSE (CTS/AtABCD1)"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Lysosomal Localization and Function of TTYH Transporters"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cross-Talk Between Organelles and Different Channels/Transporters
Highlighting novel players in the organellar network in animals and photosynthetic organisms.
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
"Ion Channels in the Intracellular Vesicles"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Calcium Signal Propagation Between Endoplasmic Reticulum and Mitochondria"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Cross Talk Between Chloroplast and Mitochondria in Microalgae: A Critical Analysis"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Optical Control of Membrane Tethering and Inter-Organellar Communications"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Pathophysiology of Intracellular Channels and Transporters
Targeting various pathologies via modulation of ion fluxes.
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"Endolysosomal Two-Pore Channels in Normal Physiology and Disease"
9:35 am - 9:40 am
Discussion
9:40 am - 10:05 am
"The Lysosome in Nutrient Sensing and Cellular Growth Control"
10:05 am - 10:10 am
Discussion
10:10 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
"VDAC1 as a Target: Crossing the Aisle from Cancer to Neurodegeneration and Diabetes"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
"Melanosomal Ion Channels Critical for Pigmentation"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
"A Negative Feedback Regulation of mTOR Activity by the Lysosomal Ca2+ Channel TRPML1 Using a Calmodulin-Dependent Mechanism"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"TMCO1 Is an ER Ca2+ Load-Activated Ca2+ (CLAC) Channel"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Contribution of F-ATP Synthase Subunits to Formation and Modulation of the Permeability Transition Pore - Mitochondrial Megachannel"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Mitochondrial Calcium Uniporter Controls AMPK Activity and Lipid Metabolism"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Ion Transport in Vacuoles
Impact of ion and small-molecule transport on the physiology of vacuoles.
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
"The Role of the Vacuolar ALMT Anion Channels in Stomata Movement and Salt Tolerance"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Molecular Mechanism of Sugar Transport by the SWEET Family Transporter"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Structure of the Vacuolar TPC1 Channel from Arabidopsis thaliana "
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Arabidopsis MATE-Type Anion Channels and Their Function in Turgor Regulation"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Channels/Transporters of the Endoplasmatic Reticulum and Nucleus
Speakers in this session use cutting edge approaches to uncover structure/function of old and new transporters in animals and plants.
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"Structural Basis of Calcium Activation of Ryanodine Receptor"
9:35 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Intracellular TRIC Channels: Electrophysiological and Pathophysiological Characterization"
10:05 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
"Molecular Mechanism of the IP3 -Activated Calcium Release Channel: Insights from Cryo-EM Studies"
11:05 am - 11:10 am
Discussion
11:10 am - 11:35 am
"Nuclear Calcium Signalling"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
"A ER-Localized Anion Channel Regulates Internal Calcium Release"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Regulation of Intracellular Calcium Dynamics by a Novel Leak Channel in ER"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Mitochondria Control Store-Operated Ca2+ Entry Through Na+ and Redox Signals"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: New Organellar Channels and Transporters
The keynote session will link new proteins to organellar transport function.
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:30 pm
"Biogenesis of Mitochondrial Transporters"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
"Protein Translocases in the Inner Envelope Membrane of Chloroplasts"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:05 pm
"CLIC5 Localizes to the Inner Mitochondrial Membrane and Modulates Its Cardiac Mitochondrial Reactive Oxygen Species"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
General Discussion
9:25 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure