| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and check-in |
| 6:00 pm | Dinner |
| 7:15 pm | Welcome and Announcements |
| 7:30 pm - 9:30 pm | NEW CHEMISTRY |
| Discussion Leader: Michael Harmata (Univ. of Missouri) |
| 7:30 pm - 8:20 pm | Scott Denmark (Univ. of Illinois)
"New Vistas in Organosilicon Chemistry" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 9:20 pm | Lutz Tietze (Georg-August-Universität, Göttingen)
"Domino Reactions in the Synthesis of Natural Products and Combinatorial Chemistry" |
| 9:20 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Photo Session - Meet by Library Promptly at 8:30 am |
| 8:50 am | Announcements |
| 9:00 am - 10:00 am | CASE STUDIES IN INDUSTRIAL SYNTHESIS |
| Discussion Leader: Mezzie Ash (Dow AgroSciences) |
| 9:00 am - 9:25 am | Robert Dugger (Pfizer Groton)
"Synthesis of the CETP Inhibitor CP-529,414" |
| 9:25 am - 9:30 am | Discussion |
| 9:30 am - 9:55 am | Shankar Swaminathan (Bristol Myers-Squibb)
"Á Telescoped, Process-Friendly and Robust Macrolactamization
for an Oncology Candidate, BMS-247,550" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am | Coffee Break |
| 10:20 am - 12:30 pm | SYNTHETIC METHODOLOGY AND CATALYSIS |
| Discussion Leader: Chulbom Lee (Princeton Univ.) |
| 10:30 am - 11:10 am | Greg Fu (MIT)
"Palladium-Catalyzed Coupling Reactions" |
| 11:10 am - 11:15 am | Discussion |
| 11:15 am - 11:40 am | Jeffrey Johnston (Indiana Univ.)
"The Development of New Reagents for Asymmetric Synthesis and
Catalysis" |
| 11:40 pm - 11:45 pm | Discussion |
| 11:45 am - 12:25 pm | Peter Wipf (Univ. of Pittsburgh)
"Synthesis of Natural Product-Based Thioredoxin Inhibitors" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:00 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | SYNTHETIC METHODOLOGY FOR HETEROCYCLES |
| Discussion Leader: Fraser Fleming (Duquesne Univ.) |
| 7:30 pm - 7:55 pm | Mercedes Amat (Univ. de Barcelona)
"New Methodologies for the Enantioselective Synthesis of Bioactive
Piperidine-Containing Compounds" |
| 7:55 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:25 pm | Richard Hsung (Univ. of Minnesota)
"Stereoselective Methodologies Using Chiral Allenamides and Ynamides" |
| 8:25 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:55 pm | David Gin (Univ. of Illinois)
"Synthesis of Pyrrolidine Alkaloids" |
| 8:55 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:25 pm | Andre Charette (Univ. de Montréal)
"Catalytic, Enantioselective Nucleophilic Addition to C=N Derivatives" |
| 9:25 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:50 am | Announcements |
| 9:00 am - 12:30 pm | CASE STUDIES IN INDUSTRIAL SYNTHESIS |
| Discussion Leader: Neil Boaz (Eastman Fine Chemicals) |
| 9:00 am - 9:25 am | Mahavir Prashad (Novartis)
"Process Development of TKA731: A Tachykinin Receptor Antagonist" |
| 9:25 am - 9:30 am | Discussion |
| 9:30 am - 9:55 am | Jiong (Jack) Chen (Pharmacia)
"Scale-up of an Oxazolidinone - Battles Against Impurities" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am | Coffee Break |
| 10:30 am - 12:30 pm | ORGANOMETALLIC CHEMISTRY |
| Discussion Leader: Cathleen Crudden |
| 10:30 am - 11:20 am | Miwako Mori (Hokkaido Univ.)
"Novel Nickel-Promoted and -Catalyzed CO2 Incorporation Reaction" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:55 am | Kuiling Ding (Shanghai Institute of Org. Chemistry)
"Combinatorial Approach to Chiral Catalyst Engineering and Screening" |
| 11:55 am - 12:00 pm | Discussion |
| 12:00 pm - 12:25 pm | P. Andrew Evans (Indiana Univ.)
"New Metal-Mediated Cross-Coupling and Annulation Reactions" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:00 pm - 6:00 pm | Free Time |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | RADICAL AND NOVEL CHEMISTRY |
| Discussion Leader: Terry Rathman (FMC) |
| 7:30 pm - 8:10 pm | Philippe Renaud (Univ. of Bern)
"Radical Alternatives to Classical Reactions" |
| 8:10 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:55 pm | Jeff Marcoux (Merck)
"Recent Studies in Practical Synthesis" |
| 8:55 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:25 pm | Paul Floreancig (Univ. of Pittsburgh)
"Electrophile Formation from Unconventional Precursors" |
| 9:25 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:45 am - 9:00 am | Announcements and Nominations for 2005 Conference Chair |
| 9:00 am - 10:30 pm | NEW CHEMISTRY FROM INDUSTRY |
| Discussion Leader: Ioannis Houpis (Eli Lilly Belgium) |
| 9:00 am - 9:25 am | Xiu Wang (Abbott)
"Highly Selective Borohydride Reagents for Reductive Amination" |
| 9:25 am - 9:30 am | Discussion |
| 9:30 am - 9:55 am | Xini Zhang (R. W. Johnson)
"Use of Continuous Microreactor Technology in Process Research
for Early Drug Development" |
| 10:00 am | Coffee Break |
| 10:30 am - 12:30 pm | NEW CHEMISTRY |
| Discussion Leader: Marc Snapper (Boston College) |
| 10:30 am - 11:20 am | Dieter Hoppe (Universität Münster)
"New Synthetic Applications of Chiral Organolithium Compounds" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:55 am | Helena Malinakova (Univ. of Kansas)
"Palladacycles with a Metal-Bonded Stereogenic Carbon. New Tools for Organic Synthesis" |
| 11:55 am - 12:00 pm | Discussion |
| 12:00 pm - 12:25 pm | Scott Miller (Boston College)
"Peptide-Catalyzed Asymmetric Reactions for Organic Synthesis" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:00 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session II |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | SYNTHETIC METHODOLOGY AND CATALYSIS |
| Discussion Leader: John Wolfe (Univ. of Michigan) |
| 7:30 pm - 8:20 pm | William Roush (Univ. of Michigan)
"Development of New Carbonyl Allylation Reactions for Application Towards Natural Product Synthesis" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 9:20 pm | Eric Jacobsen (Harvard Univ.)
"The Hydrolytic Kinetic Resolution" |
| 9:20 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:45 am - 9:00 am | Announcements and Election of 2005 Conference Chair |
| 9:00 am - 10:00 am | INDUSTRIAL CHEMICAL DEVELOPMENT |
| Discussion Leader: Bill Nugent (Bristol Myers-Squibb) |
| 9:00 am - 9:25 am | Jade Nelson (Pfizer Holland)
"An Asymmetric Hydrogenation-Based Process for Atorvastatin Lactone Production" |
| 9:25 am - 9:30 am | Discussion |
| 9:30 am - 9:55 am | Joe Adams (GlaxoSmithKline UK)
"GW559090A: Chemical Development of a Potential -4 Integrin Antagonist for the Treatment of Asthma" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am - 10:15 am | Conference Evaluation |
| 10:15 am - 10:30 am | Coffee Break |
| 10:30 am - 12:30 pm | TOTAL SYNTHESIS AND CATALYSIS |
| Discussion Leader: Marisa Koslowski (Univ. of Pennsylvania) |
| 10:30 am - 10:55 am | Tony Zhang (Eli Lilly & Co.)
"Process Development of Cryptophycins, A Biosynthetic Approach" |
| 10:55 am - 11:00 am | Discussion |
| 11:00 am - 11:25 am | Michael Krische (Univ. of Texas)
"Enones as Latent Enolates in Catalysis" |
| 11:25 am - 11:30 am | Discussion |
| 11:30 am - 12:20 pm | Masakatsu Shibasaki (Univ. of Tokyo)
"Asymmetric Catalysis in Target-Oriented Synthesis" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:00 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Chair's Reception |
| 6:00 pm | Conference Banquet |
| 7:30 pm - 9:30 pm | SCIENCE AND ART |
| Discussion Leader: Kay Brummond (Univ. of Pittsburgh) |
| 7:30 pm - 8:30 pm | Donald Williams (The Smithsonian Institute)
"At the Intersection of the Left Brain and the Right Brain: Creative Applications of Materials Science for the Preservation of Art" |
| 8:30 pm - 8:45 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
