| Sunday | 
| 2:00 pm - 9:00 pm | Arrival and Check-in | 
| 6:00 pm | Dinner | 
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff | 
 | 7:40 pm - 9:30 pm | Strategies
for Preparing Complex Molecules | 
  | Discussion Leader: Scott Sieburth (Temple University, USA) | 
 | 7:40 pm - 8:05 pm | Kevin Brown (Indiana University, USA)  "No Strain, No Gain: Advances in the Synthesis and Use of Cyclobutanes" | 
| 8:05 pm - 8:15 pm | Discussion | 
| 8:15 pm - 8:40 pm | David Waller (Merck & Co. Inc., USA)  "The Cross-Coupling Approach to Cephalosporin Antibiotics" | 
| 8:40 pm - 8:50 pm | Discussion | 
| 8:50 pm - 9:20 pm | Andre Beauchemin (University of Ottawa, Canada)  "Reaction Development Using Temporary Intramolecularity and Amphoteric Isocyanates" | 
| 9:20 pm - 9:30 pm | Discussion | 
 
| Monday | 
| 7:30 am - 8:30 am | Breakfast | 
 | 9:00 am - 12:30 pm | Inspired
by Nature: Biomimetic Syntheses,
Biocatalysis, and Applications of "Large Molecules" | 
  | Discussion Leaders: Hosea Nelson (University of California, Los Angeles, USA) and Pamela Tadross (Merck & Co. Inc., USA) | 
 | 9:00 am - 9:30 am | Thomas Maimone (University of California, Berkeley, USA)  "Synthesis of Complex Terpenes from Simple Precursors" | 
| 9:30 am - 9:45 am | Discussion | 
| 9:45 am - 10:15 am | Jared Lewis (University of Chicago, USA)  "Engineering Proteins for Selective Catalysis" | 
| 10:15 am - 10:30 am | Discussion | 
| 10:30 am - 11:00 am | Coffee Break | 
| 11:00 am - 11:30 am | Robert Linhardt (Rensselaer Polytechnic Institute, USA)  "Chemoenzymatic Synthesis of Heparin and Low Molecular Weight Heparins" | 
| 11:30 am - 11:45 am | Discussion | 
| 11:45 am - 12:15 pm | David Entwistle (Codexis Inc., USA)  "Enzyme Evolution for Pharmaceutical Manufacture" | 
| 12:15 pm - 12:30 pm | Discussion | 
 
| 12:30 pm | Lunch | 
| 1:30 pm - 4:00 pm | Free Time | 
| 4:00 pm - 6:00 pm | Poster Session | 
 
 
 
| 6:00 pm | Dinner | 
 | 7:30 pm - 9:30 pm | Going
with or Against the Flow: Guidelines and Applications for Continuous-Flow
Operations | 
  | Discussion Leader: Dominique Hebrault (Mettler Toledo, USA) | 
 | 7:30 pm - 8:00 pm | Nicola Pohl (Indiana University, USA)  "A Systems Approach to Tackling the Challenges of Carbohydrate Synthesis and Analysis" | 
| 8:00 pm - 8:10 pm | Discussion | 
| 8:10 pm - 8:40 pm | Klavs Jensen (Massachusetts Institute of Technology, USA)  "Automated Organic Chemistry for Screening, Optimization, and Scaling" | 
| 8:40 pm - 8:50 pm | Discussion | 
| 8:50 pm - 9:20 pm | Martin Johnson (Eli Lilly and Company, USA)  "Applications of Continuous Reactors in Pharmaceutical Manufacturing" | 
| 9:20 pm - 9:30 pm | Discussion | 
 
| Tuesday | 
| 7:30 am - 8:30 am | Breakfast | 
| 8:30 am | Group Photo | 
 | 9:00 am - 12:30 pm | Precious
or Non-Precious Metals: Organometallic
Reagents Using or Avoiding Transition Metals, Precious Metals, and Rare Earth
Elements | 
  | Discussion Leaders: Jennifer Roizen (Duke University, USA) and Vladimir Gevorgyan (University of Illinois at Chicago, USA) | 
 | 9:00 am - 9:30 am | Olafs Daugulis (University of Houston, USA)  "New Methods for Carbon-Hydrogen Bond Functionalization" | 
| 9:30 am - 9:45 am | Discussion | 
| 9:45 am - 10:15 am | Donald Watson (Univesity of Delaware, USA)  "Recent Progress in Heteroatomic Heck Reactions" | 
| 10:15 am - 10:30 am | Discussion | 
| 10:30 am - 11:00 am | Coffee Break | 
| 11:00 am - 11:30 am | Kami Hull (University of Illinois at Urbana-Champaign, USA)  "Transition Metal-Catalyzed Amination and Amidation Reactions" | 
| 11:30 am - 11:45 am | Discussion | 
| 11:45 am - 12:15 pm | Veronique Gouverneur (Oxford University, United Kingdom)  "Fluorine Chemistry: Chemical, Radiochemical and Clinical Advances" | 
| 12:15 pm - 12:30 pm | Discussion | 
 
| 12:30 pm | Lunch | 
| 1:30 pm - 4:00 pm | Free Time | 
 | 4:00 pm - 6:00 pm | Poster Session | 
 
 
 
| 6:00 pm | Dinner | 
 | 7:30 pm - 9:30 pm | From Flask to Reactor:
Strategies and Tactics for Scale-Up | 
  | Discussion Leader: Sergey Pronin (University of California, Irvine, USA) | 
 | 7:30 pm - 8:00 pm | Brenda Burke (Gilead Sciences, Inc., USA)  "Process Chemistry Development of Ledipasvir - NS5A Inhibitor in HarvoniĀ® for Hepatitis C Treatment" | 
| 8:00 pm - 8:10 pm | Discussion | 
| 8:10 pm - 8:40 pm | Michael Bech Sommer (Awapatent A/S, Denmark)  "Courtroom Chemistry and Molecules with a Legal Twist" | 
| 8:40 pm - 8:50 pm | Discussion | 
| 8:50 pm - 9:20 pm | Ryan Shenvi (Scripps Research Institute, USA)  "Persistence" | 
| 9:20 pm - 9:30 pm | Discussion | 
 
| Wednesday | 
| 7:30 am - 8:30 am | Breakfast | 
 | 9:00 am - 12:30 pm | Enlightening Tools: Photoredox Catalysis and
Other "One-Electron" Chemistry | 
  | Discussion Leaders: David Michaelis (Brigham Young University, USA) and Daniele Leonori (The University of Manchester, United Kingdom) | 
 | 9:00 am - 9:30 am | Melanie Sanford (University of Michigan, USA)  "Recent Developments in Catalytic C-H Functionalization" | 
| 9:30 am - 9:45 am | Discussion | 
| 9:45 am - 10:15 am | Tehshik Yoon (University of Wisconsin-Madison, USA)  "A General Strategy for Stereocontrol in Photochemical Reactions" | 
| 10:15 am - 10:30 am | Discussion | 
| 10:30 am - 11:00 am | Coffee Break | 
| 11:00 am - 11:30 am | Robert Knowles (Princeton University, USA)  "Proton Coupled Electron Transfer in Organic Synthesis" | 
| 11:30 am - 11:45 am | Discussion | 
| 11:45 am - 12:15 pm | David MacMillan (Princeton University, USA)  "The Use of Photoredox Catalysis to Invent or Discover Unique One-Electron Mediated Reactions" | 
| 12:15 pm - 12:30 pm | Discussion | 
 
| 12:30 pm | Lunch | 
| 1:30 pm - 4:00 pm | Free Time | 
 | 4:00 pm - 6:00 pm | Poster Session | 
 
 
 
| 6:00 pm | Dinner | 
| 7:00 pm - 7:30 pm | Business Meeting | 
 | Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair | 
 | 7:30 pm - 9:30 pm | Approaches for Innovative Medicines | 
  | Discussion Leader: Yi-Yin Ku (AbbVie, USA) | 
 | 7:30 pm - 8:00 pm | Nicole Goodwin (GlaxoSmithKline, USA)  "Split Kinase Personalities: Type I and Type III Inhibitors of LIMK2" | 
| 8:00 pm - 8:10 pm | Discussion | 
| 8:10 pm - 8:40 pm | Thomas Razler (Bristol-Myers Squibb, USA)  "Development of the Commercial Synthesis of Gamma Secretase Inhibitor BMS-708163 (Avagacestat)" | 
| 8:40 pm - 8:50 pm | Discussion | 
| 8:50 pm - 9:20 pm | Kris Jones (Pfizer, USA)  "Development of Ertugliflozin, a Novel SGLT2i Inhibitor: From Sugar to Co-Crystal" | 
| 9:20 pm - 9:30 pm | Discussion | 
 
| Thursday | 
| 7:30 am - 8:30 am | Breakfast | 
 | 9:00 am - 12:30 pm | Advances in Catalysis and Reaction Mechanisms | 
  | Discussion Leaders: Silas Cook (Indiana University, USA) and Matthew Beaver (Amgen, USA) | 
 | 9:00 am - 9:30 am | Matthew Meyer (University of California, Merced, USA)  "Exploring the Selectivity Problem in Chemistry Using Isotopes" | 
| 9:30 am - 9:40 am | Discussion | 
| 9:40 am - 10:10 am | Jean-Philip Lumb (McGill University, Canada)  "Driving Synthesis by Oxidation" | 
| 10:10 am - 10:20 am | Discussion | 
| 10:20 am - 10:35 am | Coffee Break | 
| 10:35 am - 11:00 am | Johan Wennerberg (Chemoswed AB, Sweden)  "Development of a Practical and Safe Synthesis of ABR-215062" | 
| 11:00 am - 11:10 am | Discussion | 
| 11:10 am - 11:35 am | John Limanto (Merck Sharp & Dohme, USA)  "Development of a Long-Term Manufacturing Route to an HCV NS5b Inhibitor" | 
| 11:35 am - 11:45 am | Discussion | 
| 11:45 am - 11:55 am | Jill Caputo (University of Rochester, USA)  "Teaching an Old Dot New Tricks: The Use of Quantum Dots in Photoredox Catalysis" | 
| 11:55 am - 12:00 pm | Discussion | 
| 12:00 pm - 12:10 pm | Justin Mohr (University of Illinois at Chicago, USA)  "Regio- and Stereocontrol with Anions and Radicals" | 
| 12:10 pm - 12:15 pm | Discussion | 
| 12:15 pm - 12:25 pm | Alexandr Shafir (Institute of Chemical Research of Catalonia (ICIQ), Spain)  "New Concepts for Engaging the Haloarenes in CH Functionalization: Halogen Retention for Downstream Diversification" | 
| 12:25 pm - 12:30 pm | Discussion | 
 
| 12:30 pm | Lunch | 
| 1:30 pm - 4:00 pm | Free Time | 
 | 4:00 pm - 6:00 pm | Poster Session | 
 
 
 
| 6:00 pm | Dinner | 
 | 7:30 pm - 9:30 pm | Keynote Session: The Mystery of Organic Chemistry: Exploiting Surprises, Molecular Machines,
and Legerdemain | 
  | Discussion Leader: Travis Remarchuk (Denali Therapeutics, Inc., USA) | 
 | 7:30 pm - 8:00 pm | Sergey Pronin (University of California, Irvine, USA)  "New Methods and Strategies for the Synthesis of Indole Diterpenes" | 
| 8:00 pm - 8:10 pm | Discussion | 
| 8:10 pm - 8:40 pm | Bo Qu (Boehringer Ingelheim Pharmaceuticals, USA)  "An Ideal Enantioselective Synthesis for BI 11β-HSD Inhibitor" | 
| 8:40 pm - 8:50 pm | Discussion | 
| 8:50 pm - 9:20 pm | Steven Raw (AstraZeneca, United Kingdom)  "Osimertinib Mesylate: Process Development and Scale-Up of an API on the Critical Path" | 
| 9:20 pm - 9:30 pm | Discussion | 
 
| Friday | 
| 7:30 am - 8:30 am | Breakfast | 
| 9:00 am | Departure |