Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
7:40 pm - 8:10 pm
"Pd-Catalyzed C-H Functionalizations: A Chameleon Changes Color"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:45 pm
"Catalytic Reactions of Diborylalkanes"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Metal-Catalyzed Coupling Reactions of Alkyl Electrophiles"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Efficient Processes in Drug Development
9:00 am - 9:30 am
"Adventures in Selective Phosphorylation and Other Reactions You Didn't Know Were Difficult"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
"Process Development of Lorlatinib"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
"Multi-Kilo Synthesis of a RORg Nuclear Hormone Receptor Agonist"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
"Development of the Manufacturing Route to Cenerimod – An S1P Receptor 1 Agonist "
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 8:00 pm
"Site-Selective Functionalization with Small and Large Catalysts"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Pd-Catalyzed Alkene Difunctionalization Reactions for the Synthesis of Heterocycles and Carbocycles"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Enantioselective and Remote C-H Activation Through Metal Insertions"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
New Reaction Technologies
9:00 am - 9:30 am
"Oxygen Driven Fragment Coupling by Activation of C-H, N-H, and O-H Bonds"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
"Asymmetric and Catalytic Transformation for BI Drug Development"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
"Evolution of a Process to Synthesize ABT-333, an HCV Polymerase Inhibitor"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
"Catalytic Reactions at Metal-Metal Bonds"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Studies of Reaction Mechanism
7:30 pm - 8:00 pm
"Turning Computational Complications into Opportunities for Reaction Optimization and Design"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Ex Detritus, Scientia: Decomposition Pathways in Olefin Metathesis"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Structure-Reactivity-Selectivity Relationships in Alkali Metal Enolates"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Synthesis of Bioactive Compounds (and Radical Cyclizations)
9:00 am - 9:30 am
"Selective Synthesis of Unusual Lipids"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
"The Catalysis of Radical Cyclizations Under H2 "
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
"Complexity from Cascades"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
"New Approaches to Bioactive Molecules"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Advances in Asymmetric Methods in
Chemical Synthesis
7:30 pm - 8:00 pm
"Catalytic Enantioselective Vinylation Reactions of Alkenes"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Late Transition Metals in Selective Isomerizations"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"New Insights in Catalysis"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Development Strategies in Process Research (and Reaction Mechanisms)
9:00 am - 9:30 am
"Process Development for the Multi-Kilogram-Scale Synthesis of an Active Pharmaceutical Ingredient"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Process Development and Application of a Pd-Catalyzed Direct Arylation in the Commercial Synthesis of the HCV NS5B Inhibitor Beclabuvir"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Adventures in Catalysis: From Mechanisms to Applications"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Highly Enantioselective Synthesis of All-Carbon Quaternary Stereocenters via Enantioconvergent SN1 Reaction"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"New Methods for Allylation: Radical Decarboxylative Allylation via Dual Catalysis"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"New Site Selective, Organocatalytic Oxidation and Amination Reactions"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Ion Pair-Directed Regiocontrol in Transition-Metal Catalysis: A Meta-Selective C-H Borylation of Aromatic Quaternary Ammonium Salts"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: The Awesome Power of Organic Synthesis
7:30 pm - 8:00 pm
"What's New with the Hexadehydro-Diels-Alder (HDDA) Reaction?"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:35 pm
"Catalyst-Controlled C-H Functionalization"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:25 pm
"A World of Collaborations"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure