Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Discoveries in Organic Synthesis
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 8:15 pm
"Synthesis and Structure Assignment of Natural Products"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:50 pm
"Stereocontrolled Cyclizations for Organic Synthesis"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:25 pm
"Enantioselective Boronate Reactions: Discovery, Catalysis and Mechanism"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Methods in Organofluorine Chemistry
9:00 am - 9:30 am
"C-C Bond Forming Reactions of Dicoordinated Carbocations"
9:30 am - 9:35 am
Discussion
9:35 am - 10:05 am
"Understanding the Preformed Catalyst Activation Mechanism in Organic Synthesis"
10:05 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:10 am
"New Electrophilic Fluoroalkylating Reagents for the Preparation of [18 F]SCF3 and [18 F]SCF2 H-Arenes"
11:10 am - 11:15 am
Discussion
11:15 am - 11:45 am
"Synthetic Biology Approaches to New Chemistry"
11:45 am - 11:50 am
Discussion
11:50 am - 12:20 pm
"Accessing Multifluorinated Arenes via Molecular Sculpting"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Modern Synthetic Methodology
7:30 pm - 8:00 pm
"Process Development of GDC-0810 and Stereoselective Formation of Tetrasubstituted Olefins"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Asymmetric Atropisoinduction"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Transition Metal/Radical Hybrid Synthetic Methods"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Catalytic Mechanisms and Theory
9:00 am - 9:30 am
"Development of a Green and Sustainable Manufacturing Process for Gefapixant (MK-7264)"
9:30 am - 9:35 am
Discussion
9:35 am - 10:05 am
"Stereoselective Synthesis of Alkenes Using Silicon and Sulfone Chemistry"
10:05 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:10 am
"Insights on the Pd(OAc)2 /Xphos Catalytic System"
11:10 am - 11:15 am
Discussion
11:15 am - 11:45 am
"Arene Coupling Reactions on Solid Porous Pd Catalysts"
11:45 am - 11:50 am
Discussion
11:50 am - 12:20 pm
"Progress Toward the Computational Design of Asymmetric Catalysts"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Functionalization of Aromatic Systems
7:30 pm - 8:00 pm
"Dearomative Functionalization with Arenophiles: Methods and Applications"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Combining CH Borylations with Other Chemical Events"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Experimental and Computational Synergy in Catalyst Design for C-H Borylation"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Advances in Process Chemistry
9:00 am - 9:30 am
"Process Development of GS-5734, an Antiviral Nucleotide Analog for the Treatment of Ebola"
9:30 am - 9:35 am
Discussion
9:35 am - 10:05 am
"Commercial Manufacture Process Development for Venclexta Under Accelerated Development"
10:05 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:10 am
"Battling with Triple-O-Seven: Route Scouting and Early Scale-Up"
11:10 am - 11:15 am
Discussion
11:15 am - 11:45 am
"Development of a Commercial Route to the Reversible BTK Inhibitor BMS-986142-01"
11:45 am - 11:55 am
Discussion
11:55 am - 12:25 pm
"Enhancing Laboratory Safety: Principles of Safe Synthetic Chemistry"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
7:30 pm - 8:00 pm
"Iron(III)-Catalyzed Carbonyl-Olefin Metathesis and Oxygen Atom Transfer"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Catalyst Development for Asymmetric Synthesis at Laboratory to Process Scale"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Complex Natural Products as a Driving Force for Discovery in Organic Chemistry"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Organometallic Catalytic Mechanisms
9:00 am - 9:30 am
"Reverse Engineering for Metal-Catalyzed Processes"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Life and Death of a Catalyst: Interrogating Deactivation and Leaching Using In Situ and In Operando Techniques"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Dynamic Catalytic Systems for Organic Synthesis and Sustainable Development"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Electrophilic Concerted Metalation-Deprotonation (eCMD): A Distinct C-H Activation Mechanism that Enables Mild Dehydrogenative Coupling with Functional Group-Dense Heteroarenes"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Progress Towards the C19 Diterpenoid Alkaloid Talatisamine"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Enantioselective Organoiodane-Catalyzed Synthesis of Fluorinated Alkyl Halide Building Blocks"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Organometallic Catalytic Methods
7:30 pm - 8:15 pm
"Biomimetic Catalysis in Green Organic Transformations"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 9:10 pm
"Olefin Metathesis Catalysts for the Preparation of Molecules and Materials"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure