Sunday
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2:00 pm - 9:00 pm |
Arrival and Check-in
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6:00 pm - 7:00 pm |
Dinner
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7:30 pm - 7:40 pm |
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
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7:40 pm - 9:30 pm |
Discoveries in Organic Synthesis
Discussion Leaders: Chulbom Lee (Seoul National University, South Korea) and George O'Doherty (Northeastern University, USA)
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7:40 pm - 7:45 pm |
Opening Remarks
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7:45 pm - 8:15 pm |
Scott Rychnovsky (University of California, Irvine, USA)
"Synthesis and Structure Assignment of Natural Products"
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8:15 pm - 8:20 pm |
Discussion
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8:20 pm - 8:50 pm |
Alison Frontier (University of Rochester, USA)
"Stereocontrolled Cyclizations for Organic Synthesis"
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8:50 pm - 8:55 pm |
Discussion
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8:55 pm - 9:25 pm |
Scott Schaus (Boston University, USA)
"Enantioselective Boronate Reactions: Discovery, Catalysis and Mechanism"
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9:25 pm - 9:30 pm |
Discussion
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Monday
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7:30 am - 8:30 am |
Breakfast
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8:30 am - 9:00 am |
Group Photo
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9:00 am - 12:30 pm |
Methods in Organofluorine Chemistry
Discussion Leaders: Michael Zacuto (Celgene, USA) and Florence Williams (University of Alberta, Canada)
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9:00 am - 9:30 am |
Hosea Nelson (University of California, Los Angeles, USA)
"C-C Bond Forming Reactions of Dicoordinated Carbocations"
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9:30 am - 9:35 am |
Discussion
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9:35 am - 10:05 am |
Thomas Colacot (MilliporeSigma, USA)
"Understanding the Preformed Catalyst Activation Mechanism in Organic Synthesis"
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10:05 am - 10:10 am |
Discussion
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10:10 am - 10:40 am |
Coffee Break
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10:40 am - 11:10 am |
Qilong Shen (Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, China)
"New Electrophilic Fluoroalkylating Reagents for the Preparation of [18F]SCF3 and [18F]SCF2H-Arenes"
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11:10 am - 11:15 am |
Discussion
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11:15 am - 11:45 am |
Michelle Chang (University of California, Berkeley, USA)
"Synthetic Biology Approaches to New Chemistry"
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11:45 am - 11:50 am |
Discussion
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11:50 am - 12:20 pm |
Jimmie Weaver (Oklahoma State University, USA)
"Accessing Multifluorinated Arenes via Molecular Sculpting"
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12:20 pm - 12:30 pm |
Discussion
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12:30 pm - 1:30 pm |
Lunch
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1:30 pm - 4:00 pm |
Free Time
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3:00 pm - 4:00 pm |
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Pamela Tadross (Merck & Co., Inc., USA)
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4:00 pm - 6:00 pm |
Poster Session
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6:00 pm - 7:00 pm |
Dinner
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7:30 pm - 9:30 pm |
Modern Synthetic Methodology
Discussion Leader: Andrew Harned (Texas Tech University, USA)
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7:30 pm - 8:00 pm |
Haiming Zhang (Genentech, Inc., USA)
"Process Development of GDC-0810 and Stereoselective Formation of Tetrasubstituted Olefins"
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8:00 pm - 8:10 pm |
Discussion
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8:10 pm - 8:40 pm |
Chad Lewis (Pfizer, USA)
"Asymmetric Atropisoinduction"
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8:40 pm - 8:50 pm |
Discussion
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8:50 pm - 9:20 pm |
Vladimir Gevorgyan (University of Illinois at Chicago, USA)
"Transition Metal/Radical Hybrid Synthetic Methods"
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9:20 pm - 9:30 pm |
Discussion
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Tuesday
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7:30 am - 8:30 am |
Breakfast
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9:00 am - 12:30 pm |
Catalytic Mechanisms and Theory
Discussion Leaders: Catherine Faler (ExxonMobil Chemical, USA) and David Nagib (The Ohio State University, USA)
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9:00 am - 9:30 am |
Kevin Maloney (Merck, USA)
"Development of a Green and Sustainable Manufacturing Process for Gefapixant (MK-7264)"
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9:30 am - 9:35 am |
Discussion
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9:35 am - 10:05 am |
Kaori Ando (Gifu University, Japan)
"Stereoselective Synthesis of Alkenes Using Silicon and Sulfone Chemistry"
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10:05 am - 10:10 am |
Discussion
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10:10 am - 10:40 am |
Coffee Break
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10:40 am - 11:10 am |
Simon Wagschal (Janssen Pharmaceutica, Johnson & Johnson, Switzerland)
"Insights on the Pd(OAc)2/Xphos Catalytic System"
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11:10 am - 11:15 am |
Discussion
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11:15 am - 11:45 am |
Dirk De Vos (KU Leuven, Belgium)
"Arene Coupling Reactions on Solid Porous Pd Catalysts"
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11:45 am - 11:50 am |
Discussion
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11:50 am - 12:20 pm |
Steven Wheeler (University of Georgia, USA)
"Progress Toward the Computational Design of Asymmetric Catalysts"
|
12:20 pm - 12:30 pm |
Discussion
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12:30 pm - 1:30 pm |
Lunch
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1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
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7:30 pm - 9:30 pm |
Functionalization of Aromatic Systems
Discussion Leader: Jennifer Roizen (Duke University, USA)
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7:30 pm - 8:00 pm |
David Sarlah (University of Illinois at Urbana-Champaign, USA)
"Dearomative Functionalization with Arenophiles: Methods and Applications"
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8:00 pm - 8:10 pm |
Discussion
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8:10 pm - 8:40 pm |
Robert Maleczka (Michigan State University, USA)
"Combining CH Borylations with Other Chemical Events"
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8:40 pm - 8:50 pm |
Discussion
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8:50 pm - 9:20 pm |
Milton Smith (Michigan State University, USA)
"Experimental and Computational Synergy in Catalyst Design for C-H Borylation"
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9:20 pm - 9:30 pm |
Discussion
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Wednesday
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7:30 am - 8:30 am |
Breakfast
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9:00 am - 12:30 pm |
Advances in Process Chemistry
Discussion Leaders: Kristin Wiglesworth (Keller and Heckman LLP, USA) and Remy Angelaud (Genentech, USA)
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9:00 am - 9:30 am |
Lars Heumann (Gilead Sciences, USA)
"Process Development of GS-5734, an Antiviral Nucleotide Analog for the Treatment of Ebola"
|
9:30 am - 9:35 am |
Discussion
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9:35 am - 10:05 am |
Yi-Yin Ku (AbbVie, USA)
"Commercial Manufacture Process Development for Venclexta Under Accelerated Development"
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10:05 am - 10:10 am |
Discussion
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10:10 am - 10:40 am |
Coffee Break
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10:40 am - 11:10 am |
Martin Juhl (Lundbeck A/S, Denmark)
"Battling with Triple-O-Seven: Route Scouting and Early Scale-Up"
|
11:10 am - 11:15 am |
Discussion
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11:15 am - 11:45 am |
Steven Wisniewski (Bristol-Myers Squibb, USA)
"Development of a Commercial Route to the Reversible BTK Inhibitor BMS-986142-01"
|
11:45 am - 11:55 am |
Discussion
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11:55 am - 12:25 pm |
Craig Merlic (University of California, Los Angeles, USA)
"Enhancing Laboratory Safety: Principles of Safe Synthetic Chemistry"
|
12:25 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
|
7:00 pm - 7:30 pm |
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
|
7:30 pm - 9:30 pm |
Novel Catalytic Methods
Discussion Leader: Mark Biscoe (The City College of New York, USA)
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7:30 pm - 8:00 pm |
Corinna Schindler (University of Michigan, USA)
"Iron(III)-Catalyzed Carbonyl-Olefin Metathesis and Oxygen Atom Transfer"
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8:00 pm - 8:10 pm |
Discussion
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8:10 pm - 8:40 pm |
Joshua Sieber (Virginia Commonwealth University, USA)
"Catalyst Development for Asymmetric Synthesis at Laboratory to Process Scale"
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8:40 pm - 8:50 pm |
Discussion
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8:50 pm - 9:20 pm |
Brian Stoltz (California Institute of Technology, USA)
"Complex Natural Products as a Driving Force for Discovery in Organic Chemistry"
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9:20 pm - 9:30 pm |
Discussion
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Thursday
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7:30 am - 8:30 am |
Breakfast
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9:00 am - 12:30 pm |
Organometallic Catalytic Mechanisms
Discussion Leaders: Jean Suffert (University of Strasbourg / CNRS, France) and Pamela Tadross (Merck & Co., Inc., USA)
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9:00 am - 9:30 am |
Laurence Grimaud (Ecole Normale Supérieure, France)
"Reverse Engineering for Metal-Catalyzed Processes"
|
9:30 am - 9:40 am |
Discussion
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9:40 am - 10:10 am |
Mimi Hii (Imperial College London, United Kingdom)
"Life and Death of a Catalyst: Interrogating Deactivation and Leaching Using In Situ and In Operando Techniques"
|
10:10 am - 10:20 am |
Discussion
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10:20 am - 10:50 am |
Coffee Break
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10:50 am - 11:20 am |
Valentine Ananikov (Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Russia)
"Dynamic Catalytic Systems for Organic Synthesis and Sustainable Development"
|
11:20 am - 11:30 am |
Discussion
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11:30 am - 11:45 am |
Brad Carrow (Princeton University, USA)
"Electrophilic Concerted Metalation-Deprotonation (eCMD): A Distinct C-H Activation Mechanism that Enables Mild Dehydrogenative Coupling with Functional Group-Dense Heteroarenes"
|
11:45 am - 11:50 am |
Discussion
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11:50 am - 12:05 pm |
Alice Wong (California Institute of Technology, USA)
"Progress Towards the C19 Diterpenoid Alkaloid Talatisamine"
|
12:05 pm - 12:10 pm |
Discussion
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12:10 pm - 12:25 pm |
Mark Levin (Harvard University, USA)
"Enantioselective Organoiodane-Catalyzed Synthesis of Fluorinated Alkyl Halide Building Blocks"
|
12:25 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
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1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
|
7:30 pm - 9:30 pm |
Organometallic Catalytic Methods
Discussion Leaders: Mitchell Croatt (University of North Carolina at Greensboro, USA) and Yi Hsiao (Bristol-Myers Squibb, USA)
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7:30 pm - 8:15 pm |
Jan Backvall (Stockholm University, Sweden)
"Biomimetic Catalysis in Green Organic Transformations"
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8:15 pm - 8:25 pm |
Discussion
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8:25 pm - 9:10 pm |
Robert H. Grubbs (California Institute of Technology, USA)
"Olefin Metathesis Catalysts for the Preparation of Molecules and Materials"
|
9:10 pm - 9:20 pm |
Discussion
|
9:20 pm - 9:30 pm |
Closing Remarks
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Friday
|
7:30 am - 8:30 am |
Breakfast
|
9:00 am |
Departure
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