Sunday 
 
 
2:00 pm - 9:00 pm 
	
Arrival and Check-in
 
 
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						
7:30 pm - 7:40 pm 
	
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
 
 
						
7:40 pm - 9:30 pm 
	
Transition Metal Catalysis to Generate Complexity and Chirality 
 
 
 
						
7:40 pm - 8:00 pm 
	
Introduction by Discussion Leader
 
 
						
8:00 pm - 8:35 pm 
	
"Cross-Coupling Reactions of Sulfones–Complexity, Chirality and Control" 
 
 
 
						
8:35 pm - 8:45 pm 
	
Discussion
 
 
						
8:45 pm - 9:20 pm 
	
"New Transition Metal-Catalyzed Transformations for Drug Discovery and Development" 
 
 
 
						
9:20 pm - 9:30 pm 
	
Discussion
 
 
						
	Monday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						
9:00 am - 12:30 pm 
	
Organometallic Catalysis and Mechanisms 
 
 
 
						
9:00 am - 9:35 am 
	
"Towards Predictive Catalyst Design for Stereoselective C-N Bond Formation" 
 
 
 
						
9:35 am - 9:40 am 
	
Discussion
 
 
						
9:40 am - 10:15 am 
	
"New Developments in Electrosynthesis and Electrocatalysis" 
 
 
 
						
10:15 am - 10:20 am 
	
Discussion
 
 
						
10:20 am - 10:45 am 
	
Coffee Break
 
 
						
10:45 am - 11:15 am 
	
"Soluble Non-Coordinating Activators for Metallocene Catalysts" 
 
 
 
						
11:15 am - 11:20 am 
	
Discussion
 
 
						
11:20 am - 11:50 am 
	
"Implementation of a Next Generation Catalyst in the Telomerization of Butadiene to 1-Octene." 
 
 
 
						
11:50 am - 11:55 am 
	
Discussion
 
 
						
11:55 am - 12:25 pm 
	
"How a Single Biocatalytic Step Influenced an Entire Process: An Improved Manufacturing Route to Belzutifan" 
 
 
 
						
12:25 pm - 12:30 pm 
	
Discussion
 
 
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						
4:00 pm - 6:00 pm 
	
Poster Session 
 
 
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						
7:30 pm - 9:30 pm 
	
Synthesis of Complex Bioactive Molecules 
 
 
 
						
7:30 pm - 8:05 pm 
	
"Strategies for the Step-Efficient Syntheses of Polycyclic Terpenoids" 
 
 
 
						
8:05 pm - 8:10 pm 
	
Discussion
 
 
						
8:10 pm - 8:45 pm 
	
"Computationally Augmented Total Synthesis" 
 
 
 
						
8:45 pm - 8:50 pm 
	
Discussion
 
 
						
8:50 pm - 9:25 pm 
	
"Oxygen Driven Fragment Coupling for the Synthesis of Natural Products and Antibacterials" 
 
 
 
						
9:25 pm - 9:30 pm 
	
Discussion
 
 
						
	Tuesday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						
9:00 am - 12:30 pm 
	
Catalysis and Process Chemistry 
 
 
 
						
9:00 am - 9:30 am 
	
"Evolution of Improved Route for BMS-986278: Key Strategies, Decisions and Metrics" 
 
 
 
						
9:30 am - 9:35 am 
	
Discussion
 
 
						
9:35 am - 10:05 am 
	
"The Role of Chemical R&D in the Fight Against Covid-19" 
 
 
 
						
10:05 am - 10:10 am 
	
Discussion
 
 
						
10:10 am - 10:35 am 
	
Coffee Break
 
 
						
10:35 am - 11:05 am 
	
"Efficient Synthesis of Cardiac Myosin Inhibitor Aficamten for the Treatment of Hypertrophic Cardiomyopathies (HCM)" 
 
 
 
						
11:05 am - 11:10 am 
	
Discussion
 
 
						
11:10 am - 11:25 am 
	
"Conversion of Benzene to Pyridine via Traceless and Ipso-Selective Nitrene Internalization" 
 
 
 
						
11:25 am - 11:30 am 
	
Discussion
 
 
						
11:30 am - 11:45 am 
	
"Catalytic Ion Pair Reorganization: Unlocking Phosphonium Dealkylation to Access P-Chiral Compound" 
 
 
 
						
11:45 am - 11:50 am 
	
Discussion
 
 
						
11:50 am - 12:25 pm 
	
"Development of Flexible Catalysts for Organic Synthesis" 
 
 
 
						
12:25 pm - 12:30 pm 
	
Discussion
 
 
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						
4:00 pm - 6:00 pm 
	
Poster Session 
 
 
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						
7:30 pm - 9:30 pm 
	
Novel Catalytic Reactions Applied to N-Containing Systems 
 
 
 
						
7:30 pm - 8:05 pm 
	
"Selective Functionalization of Pyridines, Diazines and Pharmaceuticals via Unconventional Intermediates" 
 
 
 
						
8:05 pm - 8:10 pm 
	
Discussion
 
 
						
8:10 pm - 8:45 pm 
	
"Alternative Disconnections in N-Heterocycle Synthesis Enabled by Early Transition Metal Catalysis" 
 
 
 
						
8:45 pm - 8:50 pm 
	
Discussion
 
 
						
8:50 pm - 9:25 pm 
	
"Photochemistry & Organocatalysis: New Radical Opportunities" 
 
 
 
						
9:25 pm - 9:30 pm 
	
Discussion
 
 
						
	Wednesday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						
8:30 am - 9:00 am 
	
Group Photo
 
 
						
9:00 am - 12:30 pm 
	
Novel Strategies and Methodologies for Synthesis 
 
 
 
						
9:00 am - 9:35 am 
	
"Transfer of Reactive Intermediates from One Molecule to Another" 
 
 
 
						
9:35 am - 9:40 am 
	
Discussion
 
 
						
9:40 am - 10:10 am 
	
"Development of a Scalable Atroposelective Process to MRTX1719 – An Inhibitor of The PRMT5/MTA Complex" 
 
 
 
						
10:10 am - 10:15 am 
	
Discussion
 
 
						
10:15 am - 10:40 am 
	
Coffee Break
 
 
						
10:40 am - 11:10 am 
	
"Preparing for Process Scale Electrochemistry" 
 
 
 
						
11:10 am - 11:15 am 
	
Discussion
 
 
						
11:15 am - 11:45 am 
	
"Mechanism-Driven Improvements to the Manufacturing of KRAS G12C Inhibitor Sotorasib" 
 
 
 
						
11:45 am - 11:50 am 
	
Discussion
 
 
						
11:50 am - 12:25 pm 
	
"Transition Metals and Alternatives in Synthesis" 
 
 
 
						
12:25 pm - 12:30 pm 
	
Discussion
 
 
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						
4:00 pm - 6:00 pm 
	
Poster Session 
 
 
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						
7:30 pm - 9:30 pm 
	
Advances in Alkene- and Aromatic- Functionalization Reactions 
 
 
 
						
7:30 pm - 8:05 pm 
	
"Biocatalysis and Complex Molecule Synthesis" 
 
 
 
						
8:05 pm - 8:10 pm 
	
Discussion
 
 
						
8:10 pm - 8:45 pm 
	
"Reactivity and Selectivity Rules in Organic and Organometallic Reactions" 
 
 
 
						
8:45 pm - 8:50 pm 
	
Discussion
 
 
						
8:50 pm - 9:25 pm 
	
 
 
						
9:25 pm - 9:30 pm 
	
Discussion
 
 
						
	Thursday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						
8:30 am - 9:00 am 
	
Business Meeting 
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s) 
 
 
						
9:00 am - 12:30 pm 
	
Process Chemistry Research for the Synthesis of Pharmaceuticals 
 
 
 
						
9:00 am - 9:35 am 
	
"Asymmetric Hydrogenation with Chiral Spiro Catalysts" 
 
 
 
						
9:35 am - 9:40 am 
	
Discussion
 
 
						
9:40 am - 10:10 am 
	
"Process Optimization for the Solid-Phase Peptide Synthesis (SPPS) of Helically-Constrained (Helicon™) Peptides" 
 
 
 
						
10:10 am - 10:15 am 
	
Discussion
 
 
						
10:15 am - 10:50 am 
	
Coffee Break
 
 
						
10:50 am - 11:10 am 
	
"Functionalization of Electron-Deficient N-Heterocycles via Direct Excitation of Flavin-Dependent 'Ene'-Reductases" 
 
 
 
						
11:10 am - 11:15 am 
	
Discussion
 
 
						
11:15 am - 11:35 am 
	
"Enabling the Development of New Brønsted Acid Catalysts Using Data Science" 
 
 
 
						
11:35 am - 11:40 am 
	
Discussion
 
 
						
11:40 am - 12:00 pm 
	
"Organocatalytic Aza Pauson-Khand: A Regioselective Approach to Functionalized 2-Pyrrolines" 
 
 
 
						
12:00 pm - 12:05 pm 
	
Discussion
 
 
						
12:05 pm - 12:25 pm 
	
"Transition State Analysis of Important Reactions in Modern Photoredox Catalysis" 
 
 
 
						
12:25 pm - 12:30 pm 
	
Discussion
 
 
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						
4:00 pm - 6:00 pm 
	
Poster Session 
 
 
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						
7:30 pm - 9:30 pm 
	
Metal Catalyzed Reactions and Complex Molecule Synthesis 
 
 
 
						
7:30 pm - 8:05 pm 
	
"Synthesis in a Boron World" 
 
 
 
						
8:05 pm - 8:10 pm 
	
Discussion
 
 
						
8:10 pm - 8:45 pm 
	
"Heterogeneous Catalysts for Continuous-Flow Fine Chemical Synthesis and Hydrogen Storage/Transport" 
 
 
 
						
8:45 pm - 8:50 pm 
	
Discussion
 
 
						
8:50 pm - 9:25 pm 
	
"A Challenge for Total Synthesis ofBioactive Targets: Atom & Step Economy" 
 
 
 
						
9:25 pm - 9:30 pm 
	
Discussion
 
 
						
	Friday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						
9:00 am 
	
Departure