Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Environmental Influences on Pancreatic Tissue Homeostasis
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:10 pm
"Cellular Senescence in Tissue Damage and Repair"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"Metabolic Regulation of Beta Cell Stress"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:10 pm
"Tumor Immunology in the Pancreas"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Role of the Microenvironment in Pancreatic Disease
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Endocrine-Exocrine Signaling and PDAC Development"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Cellular Senescence and Diabetes"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
"Targeting the Metabolic Rewiring of PDAC to Limit Its Progression Towards a Metastatic Disease"
11:00 am - 11:10 am
Discussion
11:10 am - 11:25 am
"Lgr5-Derived Tuft and Goblet Cells Migrate into the Intrapancreatic Ductal System Following Injury"
11:25 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Tuft Cells Inhibit Pancreatic Tumorigenesis Through Paracrine Lipid Signaling"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Sensory Neuromodulation of Pancreatic β Cells"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Innovative In Vivo and In Vitro Models
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
"Modulators of Glucose Homeostasis"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"Teaming with Microbes to Build Beta Cell Mass: Lessons from the Zebrafish"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Genetics of Pancreatic Diseases
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Making Sense of Genome-Wide Association Studies for Pancreatic Cancer Risk"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Group Photo / Coffee Break
10:40 am - 11:00 am
"Origins of Molecular Subtypes of Pancreatic Cancer"
11:00 am - 11:10 am
Discussion
11:10 am - 11:25 am
"Longevity of Beta Cells and Protein Complexes Revealed by Isotope Imaging "
11:25 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Inability to Repair Spontaneous DNA Damage in β-Cells Is Sufficient to Drive β-Cell Dysfunction and Features of Type 2 Diabetes"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Mutations in RABL3 Alter KRAS Intracellular Trafficking and Are Associated with Familial Pancreatic Cancer"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cell Plasticity in the Pancreas
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
"Origins of Pancreatic Cancer"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Cellular Origins of PDAC"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"Mechanisms Underlying Epithelial-Mesenchymal Plasticity in the Pancreas"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cell-Cell Communication in Pancreatic Homeostasis and Disease
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Neuronal Signaling in Islet Development and Function"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"The Role of Nerves in Pancreatic Adenocarcinoma"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
"Intra-Islet and Extra-Islet Cell Signaling"
11:00 am - 11:10 am
Discussion
11:10 am - 11:25 am
"The Glycan CA19-9 Promotes Pancreatitis and Pancreatic Cancer"
11:25 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Mutant Kras Co-Opts a Progenitor-Associated Transcriptional Network to Drive Pancreatic Tumorigenesis"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Homeostatic Functions of Macrophages in the Human Pancreatic Islet Are Regulated by Purinergic Signals from Beta Cells"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Immune Cell-Tissue Cell Interactions
5:30 pm - 5:45 pm
Introduction by Discussion Leader
5:45 pm - 6:05 pm
"Role of Macrophages in Islet Niche"
6:05 pm - 6:15 pm
Discussion
6:15 pm - 6:35 pm
"Oncogenic Kras and the Cellular Cross-Talk in the Pancreatic Cancer Microenvironment"
6:35 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
"Molecular Determinants of PDAC"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:30 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Signaling Cascades in Pancreatic Physiology and Pathology
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Role of Metabolism in Pancreatic Cancer Progression"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Human Beta Cell Proliferation"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
"A Novel Scavenger Receptor of the Insulin Signaling Pathway in the Pancreas"
11:00 am - 11:10 am
Discussion
11:10 am - 11:25 am
"TET Hydroxylases Facilitate Pancreatic Endocrine Specification Through Modulating the Activity of Lineage-Specific Enhancers"
11:25 am - 11:30 am
Discussion
11:30 am - 11:45 am
"A Switch in Nutrient Sensing Controls Glucose Responsiveness of Pancreatic Beta Cells"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Stromal Microenvironment Shapes the Intratumoral Architecture of Pancreatic Cancer"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cell Programming and Reprogramming in the Pancreas
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
"Pancreatic Cell Reprogramming: Cell Fate Choices and Plasticity"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Understanding Pancreatic Cancer Heterogeneity"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"Reprogramming and Re-Reprogramming Acinar Cells: Ptf1a and Its Allies as Gatekeepers of Plasticity"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure