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Pancreatic Diseases (GRS)

Gordon Research Seminar

Cell State and Spatial Dynamics in Pancreatic Disease

June 14 - 15, 2025

Chairs

and

Jordan Hotel at Sunday River

27 Grand Circle

Newry, Maine, United States

Venue and Travel Information

Conference Description

The Pancreatic Diseases GRS provides a unique forum for young doctoral and post-doctoral researchers to present their work, discuss new methods, cutting edge ideas, and pre-published data, as well as to build collaborative relationships with their peers. Experienced mentors and trainee moderators will facilitate active participation in scientific discussion to allow all attendees to be engaged participants rather than spectators.

This outstanding seminar will focus on the multifaceted aspects of pancreatic diseases, including but not limited to pancreatitis, pancreatic cancer and diabetes. Emphasis will be on i) dissecting molecular mechanisms underlying disease pathogenesis, ii) defining cellular heterogeneity, plasticity and cell state acquisition, iii) microenvironmental impact and treatment response and iv) latest technological advances shaping the future for fundamental research.

Related Meeting

This GRS will be held in conjunction with the "Pancreatic Diseases" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
1:00 pm - 5:00 pm	Arrival and Check-in
3:30 pm - 3:45 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm	Keynote Session: Leveraging Molecular Mechanisms to Inform Clinical Translation Discussion Leader:
3:45 pm - 4:20 pm	"Insights Into Biology of Early and Advanced Pancreatic Cancer from Spatial Profiling"
4:20 pm - 4:30 pm	Discussion
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Cellular Heterogeneity and Plasticity in Pancreatic Diseases Discussion Leader:
7:30 pm - 7:35 pm	Introduction by Discussion Leader
7:35 pm - 7:50 pm	"Advances in Single-Cell-Omics of the Exocrine Pancreas"
7:50 pm - 7:55 pm	Discussion
7:55 pm - 8:05 pm	"Human Pluripotent Stem Cell-Derived Pancreatic Acinar Organoids: A Model to Study Pancreatic Development and PDAC Initiation"
8:05 pm - 8:10 pm	Discussion
8:10 pm - 8:20 pm	"eIF5A-Mediated mRNA Translation Regulates Pancreatic Cell Lineage Differentiation"
8:20 pm - 8:25 pm	Discussion
8:25 pm - 8:35 pm	"Spontaneous Conversion of Acinar Cells into Endocrine Cells in Older Mice"
8:35 pm - 8:40 pm	Discussion
8:40 pm - 8:50 pm	"Spatial Map of Native Duct Cell Populations in Human Pancreas and Their Representation in Pancreatic Cancers"
8:50 pm - 8:55 pm	Discussion
8:55 pm - 9:05 pm	"FOXA1-Mediated Epigenetic Reprogramming Drives Pancreatic Ductal Adenocarcinoma Metastasis"
9:05 pm - 9:10 pm	Discussion
9:10 pm - 9:25 pm	"Pancreatic Cancer Heterogeneity: Deconstructing Complexity"
9:25 pm - 9:30 pm	Discussion
Sunday
7:30 am - 8:30 am	Breakfast
9:00 am - 11:00 am	Tissue Micro-Environment, Drug Resistance and Biomarkers Discussion Leader:
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:15 am	"Neuroeffector Mechanisms of Parasympathetic Cholinergic Control of Pancreatic Cell Function"
9:15 am - 9:20 am	Discussion
9:20 am - 9:30 am	"Deciphering the Impact of ER-Stress on β-Cell Development and Function in MIDY Diabetic Pigs"
9:30 am - 9:35 am	Discussion
9:35 am - 9:50 am	"Gut Microbiome Depletion Rescues Germline Genetic Susceptibility to Pancreatitis and PDAC"
9:50 am - 9:55 am	Discussion
9:55 am - 10:05 am	"Targeting the Opposing Roles of the Prostaglandin E2 Receptors, EP3 and EP4, in the Pathogenesis of Type One Diabetes"
10:05 am - 10:10 am	Discussion
10:10 am - 10:20 am	"Investigating the Roles of GLI Transcription Factors in the Pancreatic Cancer Microenvironment"
10:20 am - 10:25 am	Discussion
10:25 am - 10:35 am	"Role of Sialoglycan-Siglec Axis in Pancreatic Cancer Immune Evasion"
10:35 am - 10:40 am	Discussion
10:40 am - 10:55 am	"Role of Group 2 Innate Lymphoid Cells in Pancreatic Homeostasis, Inflammation and Cancer"
10:55 am - 11:00 am	Discussion
11:00 am - 12:30 pm	Poster Session Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm	Lunch
1:30 pm - 2:30 pm	Mentorship Component: Grants, Career Advancement, and the Role of Mentorship in Scientific Development Discussion Leader:
1:30 pm - 2:30 pm	Panel Discussion Grants, Career Advancement, and the Role of Mentorship in Scientific Development
2:30 pm - 3:00 pm	Evaluation Period Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm	Seminar Concludes

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Conference History Pancreatic Diseases

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