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Phagocytes

Gordon Research Conference

June 6 - 11, 1999
Chair
Vice Chair

Conference Program

Sunday, June 6

Sunday Afternoon

3:00 - 5:00pm Registration
5:00 - 6:00pm Reception
6:00 - 7:00pm Dinner

Sunday Evening:

7:30 - 7:45pm Alan Ezekowitz
Chairman's Introduction
7:45 - 9:30 Hematopoiesis and Lineage Determination
7:45 - 7:50pm Chair: William Nauseef, University of Iowa
Introduction
7:50 - 8:20pm Stuart Orkin, Harvard Medical School
"Transcription Factor Function in Hematopoiesis."
8:20 - 8:35pm Discussion
8:35 - 9:00pm Daniel Tenen, Harvard Medical School
"Determination of Phagocyte Lineage Development by Transcription Factors PU.1 and C/EBPα"
9:00 - 9:20pm Nancy Berliner, Yale University School of Medicine
"Translational Regulation of Late Neutrophil-specific Gene Expression."
9:20 - 9:30pm Discussion
Monday, June 7

Monday Morning:

7:30 - 8:30am Breakfast
8:45 Group Photograph
9:00 - 12:30pm Phagocytosis and Host Defense
9:00 - 9:10am Chair: Thomas Stossel, Harvard Medical School
Introduction
9:10 - 9:40am Alan Aderem, University of Washington School of Medicine
"Molecular Mechanisms of Phagocytosis"
9:40 - 9:55am Discussion
9:55 - 10:25am Eric Brown, University of California, San Francisco
"Regulation of Leukocyte Integrin Adhesion"
10:25 - 10:40am Discussion
10:40 - 10:50am Break
10:50 - 11:10am Joel Swanson, University of Michigan Medical School
"Phagocytosis and Membrane Trafficking in Activated Macrophages."
11:10 - 11:25am Discussion
11:25 - 11:45am Steven Greenberg, College of Physicians & Surgeons, Columbia University
"Modular Components of Phagocytosis."
11:45 - 12:00 Discussion
12:00 - 12:20pm Emmanuelle Caron, University College London
"Small GTP-binding Proteins and the Control of Phagocytosis."
12:20 - 12:30pm Discussion
12:30 - 1:30pm Lunch
1:30 - 4:30pm Free Time
4:30 - 5:45pm Poster Session Viewing
6:00 - 7:00pm Dinner

Monday Evening:

7:30 - 9:30pm Macrophages and Development
7:30 - 7:35pm Chair: Richard Johnston, National Jewish Medical & Research Center
Introduction
7:35 - 8:00pm Nathalie Franc, Harvard Medical School
"Croquemort is Essential for Efficient Phagocytosis of Apoptotic Cells by Macrophages."
8:00 - 8:05pm Discussion
8:05 - 8:30pm Michael Hengartner, Cold Spring Harbor Laboratory
"Phagocytosis of Dying Cells in C. elegans."
8:30 - 8:35pm Discussion
8:35 - 9:00pm Gary Bokoch, Scripps Research Institute
"Mechanisms of Cytoskeletal Regulation by p21-activated Kinases."
9:00 - 9:05pm Discussion
9:05 - 9:30pm Richard Lang, New York University School of Medicine
"Macrophage Induced Programmed Cell Death."
Discussion
Tuesday, June 8

Tuesday Morning:

7:30 - 8:30am Breakfast
9:00 - 11:30am Innate Immunity
9:00 - 9:10am Chair: Peter Elsbach, New York University School of Medicine
Introduction
9:10 - 9:30am Marie Lagueux, Institute of Molecular & Cell Biology, CNRS, Strasbourg
"Innate Immunity in Insects: The Defense System of Drosophila"
9:30 - 9:45am Discussion
9:45 - 10:10am Carl Nathan, Weill Medical College of Cornell University
"NO and NO resistance genes in the host-parasite relationship"
10:10 - 10:25am Discussion
10:25 - 10:35am Break
10:35 - 11:00am Ruslan Medzhitov, Yale University School of Medicine
"Toll Receptor Family and Innate Immune Recognition."
11:00 - 11:15am Discussion
11:15 - 12:30pm Short Talks
Chairs: William Nauseef, University of Iowa
Virginia Shepherd, Vanderbilt University/VA Medical Center

Brian Egan, Vanderbilt University
Albion Wright, Kansas State University
Iain Fraser, Harvard Medical School
Zulfiqar Malik, University of Iowa
Jurgen Roes, University College, London

12:30 - 1:30pm Lunch
1:30 - 4:30pm Free Time
4:30 - 5:45pm Poster Session Viewing
6:00 - 7:00pm Dinner

Tuesday Evening:

7:30 - 8:15pm Talks from the Poster Session
Chairs: William Nauseef, University of Iowa
Virginia Shepherd, Vanderbilt University/VA Medical Center

Adam Rupper, Louisiana State University
Serhan Sakarya, University of Maryland
Trista Schagat, Duke University

8:15 - 9:30pm Regulation of Inflammation I
8:15 - 8:25pm Chair: Robert Clark, University of Texas Health Science Center
Introduction
8:25 - 8:50pm Jeffrey Ravetch, Rockefeller University
"Fc Receptors: Activators and Inhibitors of Inflammation"
8:50 - 9:00pm Discussion
9:00 - 9:25pm Michael Carroll, Harvard Medical School
"The Complement System: A Major Regulator of Inflammation"
9:25 - 9:30pm Discussion
Wednesday, June 9

Wednesday Morning:

9:00 - 10:30am NADPH Oxidase Updates
9:00 - 9:15am Chairs; Bernard Babior, Scripps Research Institute & Edgar Pick, Sackler School of Medicine
Introduction: Edgar Pick "Quo Vadis Oxidase?"
Short Talks to be selected from the Poster Session
9:15 - 9:20am Mary Dinauer, Indiana University
"Rac2 Activation of the NADPH Oxidase."
9:20 - 9:25am Discussion
9:25 - 9:35am Lydia M. Henderson, University of Bristol
"Functional Role for Histidine 115 gp91phox in Oxidase-associated H+ Channel."
9:35 - 9:40am Discussion
9:40 - 9:50am Daniel R. Ambruso, Bonfils Blood Center, Denver
"A Novel Neutrophil (PMN) Dysfunction Syndrome: Infections and Poor Wound Healing Associated with Defective Motility, Normal Expression and Function of CD11b and Diminished Contact of Rac-2."
9:50 - 9:55am Discussion
9:55 - 10:05am Françoise Morel, Laboratoire D'Enzymologie, CHU, Grenoble
"NADPH Oxidase Assembling through Cytochrome b558."
10:05 - 10:10am Discussion
10:10 - 10:20am Frank R. DeLeo, University of Iowa
"NADPH Oxidase Activation and Assembly during Phagocytosis."
10:20 - 10:25am Discussion
10:30 - 10:45am Break
10:45 - 12:30pm Regulation of Inflammation II
10:45 - 11:00am Chair: Craig Gerard, Harvard Medical School
Introduction
11:00 - 11:25am Andrew Luster, Harvard Medical School
"Chemokines: Linking Innate and Acquired Immunity."
11:25 - 11:40am Discussion
11:40 - 12:05 pm Steven Shapiro, Washington University School of Medicine
"Role of Elastases in Inflammation and Host Defense."
12:05 - 12:20pm Discussion
12:20 - 12:30pm Business Meeting
(Nominations for next Chair)
12:30 - 1:30pm Lunch
1:30 - 4:30pm Free Time
6:00 - 7:00pm Dinner

Wednesday Evening:

7:30 - 8:30pm Phagocyte Endothelial Cell Interaction
7:30 - 7:40pm Chair: Samuel Silverstein, College of Physicians & Surgeons, Columbia University
Introduction
7:40 - 8:00pm Claire Doerschuk, Harvard Medical School
"Adhesive and Biomechanical Properties of Neutrophils and Endothelial Cells"
8:00 - 8:10pm Discussion
8:10 - 8:30pm William Muller, Weill Medical College of Cornell University
"Transendothelial Migration of Leukocytes: Molecules and Mechanisms."
Discussion
8:30 - 9:30pm Bacterial Host Interactions
8:30 - 8:40pm Chair: Seymour Klebanoff, University of Washington School of Medicine
Introduction
8:40 - 9:00pm Robert Munford, University of Texas SW Medical School
"CD14-dependent utilization of extracellular phosphatidylinositol by monocytes"
9:00 - 9:10pm Discussion
9:10 - 9:30pm Samuel Wright, Merck Research Laboratories
"Recognition and transport of lipopoysaccharide"
Discussion
Thursday, June 10

Thursday Morning:

7:30 - 8:30am Breakfast
9:00 - 12:00 Phagocyte Signal Cell Transduction
9:00 - 9:15am Chair: Linda McPhail, Bowman Gray School of Medicine
Introduction
9:15 - 9:40am Giorgio Berton, Institute of General Pathology, Verona
"Signal Transduction in Phagocytic Cells: Role of Tyrosine Kinases"
9:40 - 9:55am Discussion
9:55 - 10:10am Break
10:10 - 10:35am Philip Stahl, Washington University School of Medicine
"Signal transduction, early endosomes and phagosome maturation"
10:35 - 10:55am Discussion
10:55 - 11:20am Sergio Grinstein, Hospital for Sick Children, Toronto
"Membrane Traffic during Phagosome Formation and Maturation."
11:20 - 11:35am Discussion
11:35 - 12:30pm Short Talks

Cindy Knall, National Jewish Center for Immunol & Respiratory Medicine
Kersi Pestonjamasp, University of Massachusetts School of Medicine
Patrizia Scapini, University of Verona
Jayasree Nath, Walter Reed Army Institute of Research

12:30 - 1:30pm Lunch
1:30 - 4:30pm Free time
6:00 - 7:00pm Banquet

Thursday Evening:

7:30 - 8:30pm The Zanvil Cohn Lecture
7:30 - 7:35pm Alan Ezekowitz
Introduction
7:40 - 8:10pm Siamon Gordon, William Dunn School of Pathology, Oxford
"The Macrophage and Tissue Homeostasis."
8:10 - 8:30pm Discussion
8:30 - 9:30pm Short Talks
Chair: William Nauseef, University of Iowa

Marie-Josephe Rabiet, INSERM, Grenoble
Hattie Gresham, University of New Mexico School of Medicine
Elaine Larsen, Albany Medical College
Krishnakumar Balasubramanian, M.D. Anderson Cancer Center
Friday, June 11

Friday Morning:

7:30 - 8:30am Breakfast
9:00am Bus Departure for Logan Airport

Contributors

The following organizations have generously provided financial support for the meeting:

National Institute of Allergy and Infectious Diseases
Society for Leukocyte Biology
March of Dimes Birth Defects Foundation
Merck Research Laboratories
Genentech, Inc.

Conference Links

Conference History
Additional Fee Info

MHC-Restricted Antigen Processing and Presentation
February 8 - 13, 2026


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