Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: The Hub of Signal Integration
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:00 pm
Introduction by Discussion Leader
8:00 pm - 9:00 pm
"Environmental ERKonomics"
9:00 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Metabolism: Ying and Yang of Metabolic Signaling Networks
9:00 am - 9:30 am
"Autocrine Regulation of Metabolic Functions Through Metabolite GPCRs"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Kinase-Mediated Regulation of Muscle Glucose Disposal"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
"AMP Kinase-Mediated Selective Activation of Astrocyte Glycolysis via Phosphorylation of PFKFB3 as a Novel Therapeutic Approach in Alzheimer's Disease"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:35 am
"Inflammation-Resolving Lipid Mediators and Their Receptors"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Skeletal Muscle-Specific Deletion of MKP-1 Reveals a p38 MAPK/JNK/Akt Signaling Node that Regulates Obesity-Induced Insulin Resistance"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Chaperone Mediated Assembly of mTOR Complexes"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"An Alternative G Protein Signaling Pathway Leads to Autophagy in Saccharomyces cerevisiae "
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Neuroscience: Wiring the Neuron by Phosphorylation and G-Proteins
7:30 pm - 8:00 pm
"Loss of Opioid and Gi-Dependent Inhibition of Adenylyl Cyclase After Spinal Cord Injury"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Rho Regulator-Mediated Signaling in Inter-Neuron Development and Disease"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Unmasking Aberrant Phosphorylation Networks in 16p11.2 CNV Associated Autism"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
9:00 am - 9:30 am
"PI3Kbeta Signaling in Invasion and Metastasis"
9:30 am - 9:40 am
Discussion
9:40 am - 9:50 am
"Interrogating Purinergic Signaling: From Extracellular ATP to Intracellular Second Messenger Dynamics"
9:50 am - 9:55 am
Discussion
9:55 am - 10:25 am
"PTEN and the Digital Signaling Hub"
10:25 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:15 am
"Gs Protein Subunits Avoid, but Are Not Excluded from, Clathrin-Coated Pits"
11:15 am - 11:20 am
Discussion
11:20 am - 11:30 am
"RGS10 Regulates COX-2 and TNFalpha Through G Protein Independent Mechanisms"
11:30 am - 11:35 am
Discussion
11:35 am - 12:05 pm
"Structural Basis of Opioid Receptor Function"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Quantitative Analyses of Chemoattractant-Induced Heterotrimeric G Protein Activation Kinetics in Dictyostelium Reveal Important Role for High Affinity Pre-Coupled Receptors"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cardiovascular System and Vascular Networks
7:30 pm - 8:00 pm
"Subcellular Control of Phospholipase Cepsilon Signaling in Cardiac Function"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:20 pm
"PZR Tyrosyl Phosphorylation Is Associated with Hypertrophic Cardiac Gene Expression in Shp2 Associated NSML Model Mice"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:55 pm
"High Speed Measurement of Agonist-Induced cAMP Signals in Single Cells"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
"G-Protein-Dependent and -Independent Signaling of Orphan Adhesion GPCR, GPR64"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Visualization and Model Systems in Signaling
9:00 am - 9:30 am
"Spatial Compartmentalization of Second Messengers and Kinase Complexes in Living Cells"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"G Protein-Mediated Autophagy in Yeast"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
"Quantitative Analyses of Chemoattractant-Induced Heterotrimeric G Protein Activation Kinetics in Dictyostelium Reveal Important Role for High Affinity Pre-Coupled Receptors"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:15 am
"Integrating Chemical and Mechanical Signals Through Dynamic Coupling Between Protrusions and ERK Activation"
11:15 am - 11:20 am
Discussion
11:20 am - 11:50 am
"The Allostery in G Protein Coupling: From G Proteins to Small Molecules to Cations"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Identity Matters: Ggamma-Type Dictates Efficacy of Gbetagamma Signaling and Cellular Decisions"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Conformational Regulation of Phospholipase C Enzymes"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cyclic Nucleotides and GPCR Signaling
7:30 pm - 8:00 pm
"Toward a Spatiotemporal Logic of Cellular GPCR Signaling by cAMP and PKA"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:20 pm
"Negative Feedback Phosphorylation of G Gamma Subunit Ste18 and the Ste5 Scaffold Synergistically Regulates MAPK Activation in Yeast"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:55 pm
"MAPK Pathway Regulation of Heterotrimeric G Protein Signaling Tone"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
"Therapeutic Targeting of GPCR Gbetagamma-GRK2 Signaling in Osteoarthritis"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Nexus of Phosphorylation and G-Protein Signaling
9:00 am - 9:30 am
"Regulation of the Hippo Pathway"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"New Approaches to Exploiting PTP1B as a Therapeutic Target"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
"Chemical Approaches to Identifying Kinase and Phosphatase Substrates"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:15 am
"Non-Cell Autonomous Regulation of mTORC1-Dependent Feedback Mechanisms"
11:15 am - 11:20 am
Discussion
11:20 am - 11:50 am
"Targeting RGSz1 Pathways for the Treatment of Chronic Pain"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Mechanisms Inducing Opioid Resistance After Spinal Cord Injury"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"ICK Signaling in Ciliopathy"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cancer Biology and Protein Phosphorylation
7:30 pm - 8:00 pm
"Oncogenic B-Raf Signaling in Melanoma"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"GPCR Signaling and Cancer Immune Therapies"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
"Biological Cross-Talk Between WNK1 and TGF-Beta Signaling Pathway"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
"Unraveling a Role for PKA in Mammary Development and Tumor Progression"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure