Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Tumor Stroma Interactions and Cancer Heterogeneity
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
"The Organization of Tumor-Stroma Boundaries and the Consequences for Tumor Progression"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"Mechanics, Midbodies and EMT"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Computational Modeling of Tumor Microenvironment Interactions"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Biophysical Regulation of Cell Fate Decisions by the Glycocalyx and Cell Membrane
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"(Un)jamming Transitions in Cancer Invasion: Impact of the Microenvironment"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Engineering CAR T Cells to Target Tumor-Associated MUC1 Glycoforms"
10:05 am - 10:15 am
Discussion
10:15 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
"Physical Principles of Action by the Cancer-Cell Glycocalyx"
11:05 am - 11:15 am
Discussion
11:15 am - 11:40 am
"Shaping Cell Fate Decisions by Reprogramming the Membrane Lipidome"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"A Prospective, Double-Blinded Clinical Trial Using Atomic Force Microscopy for Fast Diagnosis and Nanomechanical Subtyping of Low- and High-Risk Breast Cancers"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Fibroblast-Induced Tumor Cell Budding: When Cell Mechanics Dictate Collective Cancer Cell Invasion"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Physical Sciences Considerations of Immunooncology
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:05 pm
"Mechanisms of Resistance to Cancer Immunotherapy"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:45 pm
"Immunomodulation by Matrix Viscoelasticity"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Physical Remodeling of the Immunological Tumor Microenvironment"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Structural and Mechanical Properties of the Tumor ECM
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Imaging the Tensional State of Fibronectin Fiber Tension in Tumor Stroma"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Understanding Cell-Matrix Interactions: Cell Morphology, Stiffness and Migration Mode Regulated by Physical Forces and Chemical Signals"
10:05 am - 10:15 am
Discussion
10:15 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
"Mechanobiology of Tumor Invasion: Lessons from Glioblastoma"
11:05 am - 11:15 am
Discussion
11:15 am - 11:40 am
"ECM Remodeling During Cancer Progression"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Probing the Role of Tissue Biophysics in Metastasis"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"In Vivo Quantification of Fluid/Solid Tissue Properties by Magnetic Resonance Elastography"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:05 pm
"Overcoming Chemo- and Immuno-Therapeutic Resistance of Disseminated Tumor Cells"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:45 pm
"Nuclear Deformability and Expression of Lamin A/C as Predictors of Metastatic Potential in Breast Cancer Cells "
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Mechanotransduction of Fluid Stress in the Tumor Microenvironment"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Interfacing the Metabolic and Physical Microenvironment of Cancer
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Habitats in Tumors: Life at the Edge"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Hypoxia in the Third Dimension"
10:05 am - 10:15 am
Discussion
10:15 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
"Metabolic Systems Biology Approach to Target Tumor and Microenvironment"
11:05 am - 11:15 am
Discussion
11:15 am - 11:40 am
"Metabolic Heterogeneity in Cancer"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"New Approach to Metastasis Using a Novel Zebrafish Xenograft System"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"3D Collagen Architecture Regulates Cancer Cell Adhesion, Metabolic Stress and Collective Morphogenesis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Precision Medicine and Cancer Evolution in Clinical Trial Design
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:05 pm
"Towards Higher Resolution Precision Oncology with Primary Template-Directed Single-Cell Whole Genome Amplification"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:45 pm
"Functional Proteomic Analysis of Adaptive Response to Therapy"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Cancer Genome Evolution and Immune Escape"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Physical Considerations of Cancer Invasion and Migration
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Mechanosensitive Regulation of Cancer Proliferation"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Physical and Molecular Mechanisms by Which Stromal Architecture Regulates Carcinoma Progression"
10:05 am - 10:15 am
Discussion
10:15 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
"Viscoelastic Requirements for Cancer Cell Circulation and Migration"
11:05 am - 11:15 am
Discussion
11:15 am - 11:40 am
"Using the Plastically Deformable Particle Model to Describe Collective Cell Behavior"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Work and Dissipation in the Cell Cytoskeleton"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Unjamming and Collective Cancer Cell Motility"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cellular and Nuclear Mechanics and Mechanotransduction
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:05 pm
"Live Cell Tracking for Loss of Chromosome-5"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
"Bridging Chromatin Nanoimaging and Molecular Modeling: What Can We Learn About Chromatin Packing as a Regulator of Transcription?"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"The Physical and Biological Properties of Exosomes and Their Role in Diagnosis and Treatment of Cancer"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure