| Sunday |
| 4:00 pm - 8:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | Extracellular Proteolysis and Women's Health |
| Discussion Leaders: Robert Medcalf (Monash University, Australia), Tor Ny (Umea University, Sweden) and Marta Kubala (Children's Hospital Los Angeles, USA) |
| 7:40 pm - 8:25 pm | Zena Werb (University of California, San Francisco, USA)
"Extracellular Proteases: Regulators of Extracellular Signal Transduction in Development and Disease" |
| 8:25 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Qingyu Wu (Lerner Research Institute, Cleveland Clinic, USA)
"Molecular Mechanisms in Pregnancy-Associated Diseases: Proteases and Beyond" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Karin List (Wayne State University School of Medicine, USA)
"Role of Membrane-Anchored Serine Proteases in Carcinogenesis" |
| 9:20 pm - 9:30 pm | Discussion |
| Monday |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | Neurobiology: From Synaptic Function to Neurological Disease |
| Discussion Leaders: Sidney Strickland (The Rockefeller University, USA) and Coralie Brifault (University of California, San Diego, USA) |
| 9:00 am - 9:35 am | Manuel Yepes (Emory University, USA)
"Plasminogen Activators and Synaptic Function" |
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 10:10 am | Joachim Herz (University of Texas Southwestern Medical Center, USA)
"Proteolysis and the Regulation of Synaptic Transmission" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am - 10:45 am | Coffee Break |
| 10:45 am - 11:10 am | Wendy Campana (University of California, San Diego, USA)
"Regulation of Schwann Cell Physiology by LRP1: Role in Neuroinflammation, Regeneration and Neuropathic Pain" |
| 11:10 am - 11:20 am | Discussion |
| 11:20 am - 11:45 am | Jae Kyu Ryu (Gladstone Institutes, University of California, San Francisco, USA)
"Fibrin and CNS Innate Immunity in Neurologic Diseases" |
| 11:45 am - 11:55 am | Discussion |
| 11:55 am - 12:20 pm | Stella Tsirka (Stony Brook University, USA)
"Microglial Proteases in CNS Disease" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Structure-Function of Proteases, Receptors and Inhibitors |
| Discussion Leaders: Daniel Lawrence (University of Michigan, USA) and Agnieszka Jendroszek (Aarhus University, Denmark) |
| 7:30 pm - 7:50 pm | Ruby Law (Monash University, Australia)
"Structural Studies on Plasminogen Modulators" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Colin Kretz (University of Michigan, USA)
"Defining the Substrate Specificity of ADAMTS13 Using High Throughput Protease Profiling" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Morten Beck Trelle (University of Southern Denmark, Denmark)
"Understanding PAI-1 Unfolding and Its Functional Implications" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Nicolai Sidenius (IFOM, FIRC Institute for Molecular Oncology, Italy)
"The Proteolytic Functions of Urokinase in the Regulation of Cell Adhesion Signaling" |
| 9:20 pm - 9:30 pm | Discussion |
| Tuesday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Proteolysis in Cancer Dissemination |
| Discussion Leaders: David Waisman (Dalhousie University, Canada) and Fausto Varela (Wayne State University, USA) |
| 9:00 am - 9:35 am | Steven Gonias (University of California, San Diego, USA)
"LRP1 Functions as a Plasminogen Activator Receptor to Regulate Inflammation and Cancer Angiogenesis" |
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 10:10 am | Elena Deryugina (The Scripps Research Institute, USA)
"Proteolytic Modifications and Functional Activation of Transmembrane Molecules Involved in Metastatic Dissemination of Cancer Cells" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am - 10:45 am | Coffee Break |
| 10:45 am - 11:10 am | Malgorzata Wygrecka (Justus Liebig University, Germany)
"Intriguing Mode of Action of Moonlighting Proteins in Cancer Cell Invasion" |
| 11:10 am - 11:20 am | Discussion |
| 11:20 am - 11:45 am | Toni Antalis (University of Maryland School of Medicine, USA)
"Potent Anti-Tumor Activity of Membrane-Anchored Serine Protease-Activated Engineered Anthrax Toxins" |
| 11:45 am - 11:55 am | Discussion |
| 11:55 am - 12:20 pm | Charles Craik (University of California, San Francisco, USA)
"Development of Antibody Based Probes for Detecting Active Cancer Associated Serine Proteases" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | New Insights into Protease Functions in the Cardiovascular System |
| Discussion Leaders: William Fay (University of Missouri, USA) and Andre Samson (University of Sydney, Australia) |
| 7:30 pm - 7:50 pm | Nicola Mutch (University of Aberdeen, United Kingdom)
"Modulation of Fibrinolysis by Platelet-Derived Polyphosphate" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Imre Varju (Semmelweis University, Hungary)
"The Role of DNA, Histones and Neutrophil Extracellular Traps in the Formation and Resolution of Thrombi" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Edward Plow (Cleveland Clinic Lerner Research Institute, USA)
"Histone 2B: The Forgotten Plasminogen Receptor" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Henrik Juergensen (National Institutes of Health, USA)
"A CCR2 Macrophage Endocytic Pathway Mediates Extravascular Fibrin Clearance In Vivo" |
| 9:20 pm - 9:30 pm | Discussion |
| Wednesday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Inflammation and Infection |
| Discussion Leaders: David Ginsburg (University of Michigan Medical School, USA) and Shaun Lee (University of Notre Dame, USA) |
| 9:00 am - 9:35 am | Lirlandia Pires de Sousa (Federal University of Minas Gerais, Brazil)
"Plasmin Induces Macrophage Reprogramming and Contributes to Features of the Resolution of Inflammation" |
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 10:10 am | David Corry (Baylor College of Medicine, USA)
"The Fibrinogen-TLR4 Axis and the Control of Innate Immunity" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am - 10:50 am | Coffee Break |
| 10:50 am - 11:15 am | Tione Buranda (University of New Mexico School of Medicine, USA)
"Inflammation, P2Y2R, PAI-1 and Pathogenesis of Hantavirus Infections" |
| 11:15 am - 11:25 am | Discussion |
| 11:25 am - 11:45 am | Frank Castellino (University of Notre Dame, USA)
"Conscription of the Human Fibrinolytic System by S. pyogenes to Enhance Its Virulence" |
| 11:45 am - 11:55 am | Discussion |
| 11:55 am - 12:20 pm | Jay Degen (Cincinnati Children's Hospital Medical Center, USA)
"Genetically Disabling Fibrin Formation in Mice and the Bacterial Pathogen-Host Interface" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
| 7:30 pm - 9:30 pm | Late-Breaking Topics: The Cutting Edge |
| Discussion Leaders: Matthew Flick (Cincinnati Children's Hospital Medical Center, USA) and Vincent Ellis (University of East Anglia, United Kingdom) |
| 7:30 pm - 7:40 pm | Riku Das (Cleveland Clinic Health System, USA)
"Dietary Fat Promotes Intestinal Barrier Dysfunction and Inflammatory Polyp Formation in Plasminogen Deficient Mice" |
| 7:40 pm - 7:45 pm | Discussion |
| 7:45 pm - 7:55 pm | Jonathan Schoenecker (Vanderbilt University Medical Center, USA)
"Plasmin Prevents Muscle Transformation into Bone After Injury" |
| 7:55 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:10 pm | Wendy Mars (University of Pittsburgh, USA)
"Absence of Hepatocellular LRP1 in Aged Animals Leads to Defective Biliary Regeneration Following Bile Duct Ligation" |
| 8:10 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:25 pm | Sumeda Nandadasa (Cleveland Clinic Lerner Research Institute, USA)
"Sculpting the Mammalian Embryo, Role of ADAMTS9-Mediated ECM Proteolysis During Embryogenesis" |
| 8:25 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:40 pm | Eugenia Salcedo (University of California, San Francisco, USA)
"Global Profiling of Extracellular Proteolysis as a Molecular Stratification Tool for Breast Cancer" |
| 8:40 pm - 8:45 pm | Discussion |
| 8:45 pm - 8:55 pm | Mingdong Huang (Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, China)
"Crystal Structures of Urokinase Receptor Associated Protein (uPARAP, or endo180)" |
| 8:55 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:10 pm | Marie Ranson (University of Wollongong, Australia)
"Pancreatic Cancer Invasion and Stromal Remodling Is Dependent on Urokinase and Regulated by Serpin B2" |
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Maria Patrizia Stoppelli (National Research Council, Italy)
"Tumor-Stroma Crosstalk: Factors Secreted by c-Myc Expressing Epithelial Cells Increase Fibroblast Mobilization and Activation Through IGF-1R and uPAR" |
| 9:25 pm - 9:30 pm | Discussion |
| Thursday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Therapeutics / New Technologies |
| Discussion Leaders: Samy Meroueh (Indiana University, USA) and Thomas Bonnard (Australian Center for Blood Diseases, Australia) |
| 9:00 am - 9:35 am | Paul Declerck (University of Leuven, Belgium)
"Development of Novel Profibrinolytics" |
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 10:10 am | Robert Lazarus (Genentech, Inc., USA)
"Activators and Inhibitors of HGF/Met and MSP/Ron Signaling" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am - 10:45 am | Coffee Break |
| 10:45 am - 11:10 am | Christian Heinis (École Polytechnique Fédérale de Lausanne, Switzerland)
"Peptide Macrocycle Inhibitors of uPA and MMP-2" |
| 11:10 am - 11:20 am | Discussion |
| 11:20 am - 11:45 am | Toshio Miyata (Tohoku University, Japan)
"Inhibition of PAI-1 Regulates Cellular Regeneration and Senescence" |
| 11:45 am - 11:55 am | Discussion |
| 11:55 am - 12:20 pm | Haibo Jiang (The University of Western Australia, Australia)
"High Resolution Molecular Imaging with the NanoSIMS" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Role of Extracellular Proteolysis in Senescence and Aging |
| Discussion Leaders: Douglas Vaughan (Northwestern University, USA) and Zhen Gao (Cincinnati Children's Hospital Medical Center, USA) |
| 7:30 pm - 7:50 pm | Katherine Hajjar (Weill Cornell Medical College, USA)
"Annexin A2 and Innate Immunity" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Douglas Vaughan (Northwestern University, USA)
"Impact of a Private Mutation in PAI-1 on Aging in Humans: Insights from the Berne Amish Kindred" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Selen Catania (University of Maryland, USA)
"Mechanisms Regulating Aneurysm Formation" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Linda Fredriksson (Karolinska Institutet, Sweden)
"The Neurovascular Unit in Neurologic Disease" |
| 9:20 pm - 9:30 pm | Discussion |
| Friday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
