Sunday
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4:00 pm - 8:00 pm |
Arrival and Check-in
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6:00 pm - 7:00 pm |
Dinner
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7:30 pm - 7:40 pm |
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
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7:40 pm - 9:30 pm |
Keynote Session: Translational Impact of More than 80 Years of Research on Plasminogen Activation and Extracellular Proteolysis
Session in memory of Peter Andreasen.
Discussion Leaders: Tor Ny (Umea University, Sweden) and Dudley Strickland (University of Maryland School of Medicine, USA)
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7:40 pm - 8:25 pm |
Hau Kwaan (Feinberg School of Medicine, Northwestern University, USA)
"From Fibrinolysis to Plasminogen Activation and Beyond"
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8:25 pm - 8:30 pm |
Discussion
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8:30 pm - 8:50 pm |
Selen Catania (University of Maryland, USA)
"A Novel Role for LRP1 in Vessel Wall Homeostasis: Insight from Rare Genetic Variants"
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8:50 pm - 9:00 pm |
Discussion
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9:00 pm - 9:20 pm |
Keriann Backus (University of California, Los Angeles, USA)
"Proteome-Wide Covalent Ligand Discovery and the Development of Selective Caspase Probes"
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9:20 pm - 9:30 pm |
Discussion
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Monday
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7:30 am - 8:30 am |
Breakfast
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8:30 am - 9:00 am |
Group Photo
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9:00 am - 12:30 pm |
Proteases in Neurobiology: From the Synapse to the Bedside
Discussion Leaders: Katerina Akassoglou (Gladstone Institutes / University of California, San Francisco, USA) and Marta Kubala (Children's Hospital Los Angeles, USA)
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9:00 am - 9:30 am |
Stella Tsirka (Stony Brook University, USA)
"Microglial Proteases and CNS Disease"
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9:30 am - 9:40 am |
Discussion
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9:40 am - 10:05 am |
Robert Pawlak (University of Exeter, United Kingdom)
"Control of Anxiety by Plasmin-Mediated Cleavage of EphA4 at the Amygdala Synapses"
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10:05 am - 10:15 am |
Discussion
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10:15 am - 10:45 am |
Coffee Break
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10:45 am - 11:10 am |
Wendy Campana (University of California, San Diego, USA)
"LRP1-Signaling in Nervous System Injury"
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11:10 am - 11:20 am |
Discussion
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11:20 am - 11:45 am |
Denis Vivien (INSERM, France)
"Giving New Life to Old Music: Novel Functions of tPA in the Neurovascular Unit"
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11:45 am - 11:55 am |
Discussion
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11:55 am - 12:20 pm |
Mark Petersen (Gladstone Institutes / University of California, San Francisco, USA)
"Role of Fibrinogen in Impaired CNS Development and Regeneration"
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12:20 pm - 12:30 pm |
Discussion
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12:30 pm - 1:30 pm |
Lunch
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1:30 pm - 4:00 pm |
Free Time
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3:00 pm - 4:00 pm |
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Stella Tsirka (Stony Brook University, USA)
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4:00 pm - 6:00 pm |
Poster Session
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6:00 pm - 7:00 pm |
Dinner
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7:30 pm - 9:30 pm |
Proteases in Cardiovascular and Renal Function
Discussion Leaders: Douglas Vaughan (Northwestern University, USA) and Ariel Diaz (Emory University, USA)
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7:30 pm - 7:50 pm |
Jochen Reiser (Rush University, USA)
"suPAR: Biomarker and Biomaker of Kidney Disease"
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7:50 pm - 8:00 pm |
Discussion
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8:00 pm - 8:20 pm |
Tetsumei Urano (Hamamatsu University School of Medicine, Japan)
"Regulatory Mechanisms of the Initiation and Amplification of Fibrinolysis on Cell Surface by TAFI and PAI-1: Demonstration by Real-Time Imaging Analysis"
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8:20 pm - 8:30 pm |
Discussion
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8:30 pm - 8:50 pm |
William Fay (University of Missouri, USA)
"Proteolytic Signaling Pathways in Obesity-Associated Cardiovascular Disease"
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8:50 pm - 9:00 pm |
Discussion
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9:00 pm - 9:20 pm |
Nicola Mutch (University of Aberdeen, United Kingdom)
"The Fibrinolytic Capacity of Platelets"
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9:20 pm - 9:30 pm |
Discussion
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Tuesday
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7:30 am - 8:30 am |
Breakfast
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9:00 am - 12:30 pm |
Proteases in Inflammation, Infection and Pregnancy
Discussion Leaders: William Fay (University of Missouri, USA) and Allison Arai (University of Maryland School of Medicine, USA)
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9:00 am - 9:30 am |
Steven Gonias (University of California, San Diego, USA)
"Regulation of Innate Immunity by the Fibrinolysis System"
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9:30 am - 9:40 am |
Discussion
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9:40 am - 10:05 am |
Rashna Balsara (University of Notre Dame, USA)
"The Subversion of the Host Innate Immune System by S. pyogenes Promotes Its Survival and Virulence"
|
10:05 am - 10:15 am |
Discussion
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10:15 am - 10:45 am |
Coffee Break
|
10:45 am - 11:10 am |
Shaun Lee (University of Notre Dame, USA)
"The Role of Bacterial Proteases in Group A Streptococcal Pathogenesis"
|
11:10 am - 11:20 am |
Discussion
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11:20 am - 11:45 am |
Eric Mullins (Cincinnati Children's Research Foundation, USA)
"Plasminogen and Fibrinolysis in Neuroinflammation"
|
11:45 am - 11:55 am |
Discussion
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11:55 am - 12:20 pm |
Amy Wyatt (Flinders University , Australia)
"Non-Canonical Functions of Pregnancy-Associated Protease Inhibitors"
|
12:20 pm - 12:30 pm |
Discussion
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12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
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7:30 pm - 9:30 pm |
Structure and Function of Proteases, Receptors and Inhibitors
Discussion Leaders: Thomas Bugge (National Institute of Dental and Craniofacial Research, NIH, USA) and Joanna Cooper (University of Tennessee, USA)
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7:30 pm - 7:50 pm |
Lindsey Miles (Scripps Research Institute, USA)
"The Plasminogen Receptor, Plg-RKT, and ECM Remodeling"
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7:50 pm - 8:00 pm |
Discussion
|
8:00 pm - 8:20 pm |
Katherine Hajjar (Weill Cornell Medicine, USA)
"The Expanding Repertoire of Annexin A: Old Dogs and New Tricks"
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8:20 pm - 8:30 pm |
Discussion
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8:30 pm - 8:50 pm |
Toni Antalis (University of Maryland School of Medicine, USA)
"Membrane-Anchored Serine Proteases in Angiogenesis and Cancer"
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8:50 pm - 9:00 pm |
Discussion
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9:00 pm - 9:20 pm |
Qingyu Wu (Lerner Research Institute, Cleveland Clinic, USA)
"Membrane-Bound Serine Proteases in Liver Metabolism"
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9:20 pm - 9:30 pm |
Discussion
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Wednesday
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7:30 am - 8:30 am |
Breakfast
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9:00 am - 12:30 pm |
Proteases in Cancer
Discussion Leaders: Steven Gonias (University of California, San Diego, USA) and Stefania Belli (Institute of Genetics and Biophysics "Adriano Buzzati-Traverso", CNR, Italy)
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9:00 am - 9:25 am |
Andrey Komissarov (University of Texas Health Science Center at Tyler, USA)
"Role of PAI-1 in Slow Fibrinolysis in Chemical and Infectious Rabbit Models of Pleural Injury"
|
9:25 am - 9:35 am |
Discussion
|
9:35 am - 10:00 am |
Matthew Flick (Cincinnati Children's Hospital Medical Center, USA)
"Linking Anticoagulation and Plasminogen Activation Pathways in Pancreatic Ductal Adenocarcinoma"
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10:00 am - 10:10 am |
Discussion
|
10:10 am - 10:25 am |
Coffee Break
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10:25 am - 10:50 am |
Jaime Merchan (Miller School of Medicine, University of Miami, USA)
"Molecular Effects of uPAR-Mediated Stromal Targeting by Oncolytic Measles Virus"
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10:50 am - 11:00 am |
Discussion
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11:00 am - 11:25 am |
Michael Ploug (Rigshospitalet, Denmark)
"Structure-Based Design of uPAR-Targeting Peptides and Their Clinical Translation as Non-Invasive Imaging Tools in Solid Cancers"
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11:25 am - 11:30 am |
Discussion
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11:30 am - 11:55 am |
Maria Patrizia Stoppelli (National Research Council, Italy)
"Modulating the Pro-Invasive Activity of Fibroblasts in Tumor-Stroma Crosstalk"
|
11:55 am - 12:00 pm |
Discussion
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12:00 pm - 12:25 pm |
Wouter Moolenaar (Netherlands Cancer Institute, The Netherlands)
"Suppression of Malignant Cell Behavior Through GPI-Anchor Cleavage"
|
12:25 pm - 12:30 pm |
Discussion
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12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
|
7:00 pm - 7:30 pm |
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
|
7:30 pm - 9:30 pm |
Late-Breaking Topics
Discussion Leaders: Marie Ranson (University of Wollongong, Australia) and Coralie Brifault (University of California, San Diego, USA)
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7:30 pm - 7:40 pm |
James Whisstock (Monash University, Australia)
"Structural and Functional Characterization of Novel Classes of Plasmin and Plasminogen Inhibitors"
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7:40 pm - 7:45 pm |
Discussion
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7:45 pm - 7:55 pm |
Marta Kubala (Children's Hospital Los Angeles, USA)
"Tumor-Derived PAI-1 Promotes Macrophage M2 Polarization by Stimulating an Autocrine IL-6 /STAT3 Pathway"
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7:55 pm - 8:00 pm |
Discussion
|
8:00 pm - 8:10 pm |
Longguang Jiang (Fuzhou University, China)
"A Structural Mechanism of Flavonoids in Inhibiting Serine Proteases"
|
8:10 pm - 8:15 pm |
Discussion
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8:15 pm - 8:25 pm |
Paola Merino (Emory University, USA)
"Urokinase-Type Plasminogen Activator (uPA) Binding to the uPA Receptor (uPAR) Promotes Axonal Regeneration in the Central Nervous System"
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8:25 pm - 8:30 pm |
Discussion
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8:30 pm - 8:40 pm |
Elaine Da Silva (Ribeirão Preto Medical School, University of Sao Paulo, Brazil)
"Lympho-Epithelial Kazal-Type-Related Inhibitor (LEKTI) Inhibits Matriptase-Dependent Carcinogenesis"
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8:40 pm - 8:45 pm |
Discussion
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8:45 pm - 8:55 pm |
Audrey Thiebaut (INSERM UMR-S 1237, Cyceron, France)
"The Serine Protease tPA Modulates the Phosphorylation of mTOR and Autophagy During Ischemic Events"
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8:55 pm - 9:00 pm |
Discussion
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9:00 pm - 9:10 pm |
Gregory Conway (University of Maryland School of Medicine, USA)
"Expression of Testisin Reduces Ovarian Tumor Metastasis Through a PAR-2 - Angiopoietin Signaling Pathway"
|
9:10 pm - 9:15 pm |
Discussion
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9:15 pm - 9:25 pm |
Tierra Johnson (Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, USA)
"The Role of Plasminogen Activator Inhibitor Type-2 (PAI-2) in Modulating Venous Thrombus Resolution"
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9:25 pm - 9:30 pm |
Discussion
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Thursday
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7:30 am - 8:30 am |
Breakfast
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9:00 am - 12:30 pm |
Proteases in Aging, Cell Death and Neurodegeneration
Discussion Leaders: Paul Declerck (KU Leuven, Belgium) and Maria Daglas (Monash University, Australia)
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9:00 am - 9:30 am |
Joachim Herz (University of Texas Southwestern Medical Center, USA)
"Translational Approaches to Alzheimer's and Frontotemporal Dementia"
|
9:30 am - 9:40 am |
Discussion
|
9:40 am - 10:05 am |
Sidney Strickland (The Rockefeller University, USA)
"Vascular Contributions to Alzheimer's Disease"
|
10:05 am - 10:15 am |
Discussion
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10:15 am - 10:45 am |
Coffee Break
|
10:45 am - 11:10 am |
David Granville (University of British Columbia, Canada)
"Granzyme Serine Proteases in Aging and Chronic Disease"
|
11:10 am - 11:20 am |
Discussion
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11:20 am - 11:45 am |
Robert Medcalf (Monash University, Australia)
"Anti-Fibrinolytic Agents, Cell Death and the Immune Response"
|
11:45 am - 11:55 am |
Discussion
|
11:55 am - 12:20 pm |
Douglas Vaughan (Northwestern University, USA)
"PAI-1 and Aging-Related Morbidity"
|
12:20 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
|
7:30 pm - 9:30 pm |
New Technologies and Therapeutic Advances in Plasminogen Activation and Extracellular Proteolysis
Discussion Leaders: David Ginsburg (University of Michigan, USA) and Laura Haynes (University of Michigan, USA)
|
7:30 pm - 7:50 pm |
Daniel Lawrence (University of Michigan, USA)
"Clinical Targeting of Cerebrovascular Pathways in Ischemic Stroke"
|
7:50 pm - 8:00 pm |
Discussion
|
8:00 pm - 8:20 pm |
Mark Dewitt (Innovative Genomics Institute, University of California, Berkeley, USA)
"CRISPR/Cas9 Genome Editing for Research and Medicine"
|
8:20 pm - 8:30 pm |
Discussion
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8:30 pm - 8:50 pm |
Vladimir Muzykantov (University of Pennsylvania, USA)
"Targeted Interventions in Hematological Proteolysis"
|
8:50 pm - 9:00 pm |
Discussion
|
9:00 pm - 9:20 pm |
Paul Declerck (KU Leuven, Belgium)
"Preclinical Development of a Bispecific Profibrinolytic Agent"
|
9:20 pm - 9:30 pm |
Discussion
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Friday
|
7:30 am - 8:30 am |
Breakfast
|
9:00 am |
Departure
|