Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: The History, the Current and the Future of Fibrinolysis and Proteolysis
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:25 pm
"Bench-to-Bedside: Fibrinolytic Receptors and their Clinical Implications"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:45 pm
Introduction by Discussion Leader
8:45 pm - 9:20 pm
"Plasminogen Activation: Above and Beyond"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Proteases and Inhibitors in Thrombosis
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Targeting Fibrinogen to Suppress Thrombosis"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Coagulation-Fibrinolysis Interplay During Hemostatic/Thrombotic Plug Formation"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
"Coordination Between Anticoagulation, VWF and Fibrinolysis"
10:25 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
"The Role of ADAMTS13 in Microvascular Thrombosis"
11:25 am - 11:35 am
Discussion
11:35 am - 11:55 am
"Conformational Regulation of ADAMTS13: Molecular Insights and Pathophysiological Implications"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Fibrinolysis and Thrombolysis
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"Improving Thrombolysis in Ischemic Stroke Targeting Non-Fibrin Thrombus Structures"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Plasminogen Activation Assay and Application to Translational Studies"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
"Albumin as a Novel Modifier of Fibrin Clot Structure and Fibrinolytic Susceptibility"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:10 pm
"Interplay Between Fibrin Structure and Fibrinolysis"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Infection and Inflammation
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Seeing Is Understanding: Structural Insights into Inhibitory Antibodies"
9:25 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Structural Basis of Vitronectin's Interaction with PAI1 and Lipids"
9:50 am - 9:55 am
Discussion
9:55 am - 10:15 am
"An Immune-Mobilized State in Mac-1-Deficient Mice and Its Impact on Inflammatory Diseases"
10:15 am - 10:20 am
Discussion
10:20 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Foxp3⁺ Regulatory T Cell–Expressed Mmp12: A Proteolytic Mediator Promoting Resolution of Acute Lung Injury"
11:05 am - 11:10 am
Discussion
11:10 am - 11:30 am
"Leukocyte MMPs: From Inflammatory Mediators to Immune Regulators"
11:30 am - 11:35 am
Discussion
11:35 am - 11:55 am
"Visualizing the (Protease) Interface Between Infection, Inflammation and Coagulation in the Living Animal"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Proteases and Inhibitors in Cancer
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:35 pm
"Thrombomodulin-Mediated Activation of TAFI Targets Multiple Steps of the Metastatic Cascade"
7:35 pm - 7:55 pm
"Mechanisms of Venous Thrombosis in Pancreatic Cancer"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"Host Influence on Matrix Remodeling in Ovarian Cancer Metastasis"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
"Chemotherapy-Induced Liver Timp1 Secretion Accelerates Pancreatic Cancer Liver Metastasis"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Short Talk Selected from Poster Abstracts
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cerebrovascular Disease and Aging
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Knockdown of Endothelial Serpine1 Improves Stroke Recovery by Attenuating Peri-Infarct Blood Flow and Blood-Brain Barrier Disruption"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"LRP and SORL1 in Tau Seeding in Alzheimer's Disease"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
"Border-Associated Macrophages-Derived PAI-1 Suppresses tPA and Impairs Neurovascular Coupling in Aβ Pathology"
10:25 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
"Endothelial Laminin Maintains Blood-Brain Barrier Integrity"
11:25 am - 11:35 am
Discussion
11:35 am - 11:55 am
"From Amyloid to Synapse: MT5-MMP in the Pathophysiology of Alzheimer's Disease"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cardiovascular Diseases and Metabolic Dysfunctions
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"The Evolving Role of Occludin Phosphorylation in Ischemic Stroke"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Cell Type-Specific Regulation of PAI-1 Gene Expression"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
"Precipitating Factors of Cardiac Fibrosis in PAI-1 Deficient Mice"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:10 pm
"N-Terminomics of the Heart"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Development and Application of Technologies in Proteases and Inhibitors
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Ultra-Rapid Detection of Hyperfibrinolysis"
9:25 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Plasmin Mediated Self-Propagating Fibrinolysis"
9:50 am - 9:55 am
Discussion
9:55 am - 10:15 am
"Diagnosing the Procoagulant State of Alzheimer´s Disease"
10:15 am - 10:20 am
Discussion
10:20 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Advancing Proteolysis Signature Detection with a Novel Carboxy Terminal Peptide Enrichment Approach"
11:05 am - 11:10 am
Discussion
11:10 am - 11:30 am
"Targeting Metalloproteases with Activity-Based Probes: Advances in Development and Applications"
11:30 am - 11:35 am
Discussion
11:35 am - 11:55 am
"The Impact of pH on Proteolytic Activity in Wound Fluid: Implications for Acid Therapy"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Translational Research and Therapeutics in Protease and Inhibitors
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"Therapeutic Targeting of Immunothrombosis in Sepsis: From the Bench to Clinical Trials"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"Crosstalk Pathways Between Coagulation, Insulin Signaling and Glucometabolism"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
"Crosstalk Between Fibrinolysis and the Immune System: Implications for Antifibrinolytic and Thrombolytic Therapy"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
General Discussion
9:20 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure