Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 8:10 pm
"Spermine Oxidase: A Link Between Infection/Inflammation and Cancer"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"Circadian Clock Control by Polyamine Levels Through a Mechanism that Declines with Age"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Structure, Mechanism, and Specificity of the Eukaryotic Cytoplasmic Polyamine Deacetylase"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Impact of Polyamine Metabolism in Cancer Development
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:40 am
"Translational Control of the ODC-Polyamine Axis by a Developmental Regulator and Its Pathophysiological Relevance to Cancer"
9:40 am - 9:50 am
Discussion
9:50 am - 10:20 am
"Antizyme-Interacting Proteins in Cancer Cells"
10:20 am - 10:30 am
Discussion
10:30 am - 10:55 am
Group Photo / Coffee Break
10:55 am - 11:25 am
"Polyamines as Two-Sided Nodes in the Immunoregulatory Intersection Between Arginine and Tryptophan Metabolism"
11:25 am - 11:35 am
Discussion
11:35 am - 12:05 pm
"Cereblon-Directed Control of Polyamines Regulates Anti-Tumor T-Cell Immunity"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Polyamine Regulation of Translation and Cell Growth
7:30 pm - 8:00 pm
"Cellular and Molecular Consequences of Polyamine Depletion"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Improving Recombinant Protein Expression from Mammalian Cells by Utilizing Non-Coding RNA and Identification of Antizyme-1 as a Possible Enhancer"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Polyamine Modulon Whose Synthesis Is Enhanced by Polyamines at the Level of Translation"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Polyamines in Cellular Homeostasis and Physiology
9:00 am - 9:10 am
Opening Remarks
9:10 am - 9:40 am
"Polyamine Mediated Regulation of Wound Healing"
9:40 am - 9:50 am
Discussion
9:50 am - 10:20 am
"Regulators of Polyamine Levels as Antineoplastic Drug Targets"
10:20 am - 10:30 am
Discussion
10:30 am - 10:55 am
Coffee Break
10:55 am - 11:25 am
"Polyamine and Hypusine Biosynthesis Is Required for Proper Pancreas Development"
11:25 am - 11:35 am
Discussion
11:35 am - 12:05 pm
"The 6,000 Calorie Question"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"The Polyamigo Gene: A Human ATP13A3 Ortholog Required for Polyamine Transport in Drosophila "
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Polyamines and Their Pleiotropic Effects
7:30 pm - 8:00 pm
"Regulation of Polyamine Biosynthesis in Trypanosomatid Parasites"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Arginine Sensing and Its Role in Virulence of the Human Pathogen Leishmania"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Immune-Mediated Polyamine Pathway Flux in Neurodegenerative Disease"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Novel Cancer Therapies Targeting Polyamine Pathways
9:00 am - 9:10 am
Opening Remarks
9:10 am - 9:40 am
"Therapeutic Potential of Polyamine Catabolism Activation in Combination with Methionine Salvage"
9:40 am - 9:50 am
Discussion
9:50 am - 10:20 am
"Anti-Tumor Effects of Novel Arylpolyamine Drugs"
10:20 am - 10:30 am
Discussion
10:30 am - 10:55 am
Coffee Break
10:55 am - 11:25 am
"Depleting Polyamines to Target MYC-Driven Cancers and Their Immunosuppressive Microenvironment"
11:25 am - 11:35 am
Discussion
11:35 am - 12:05 pm
"Regulation of Antizyme Biosynthesis by Polyamines and Their Analogues"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Metabolic Diversity of Polyamine Function
7:30 pm - 8:00 pm
"Role of Polyamines and DFMO in Helicobacter pylori -Induced Gastric Carcinogenesis"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"How Putrescine Increases Host Susceptibility to the Plant Pathogenic Bacterium Ralstonia solanacearum "
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Higher Polyamines Revive Metabolic Memory and Upregulate Bioactive and Chemopreventive Molecules in Transgenic Tomato Fruit"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Drug Discovery and Development
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:40 am
"Polyamine Analogues as Anti-Infective Agents for Wild-Type and Resistant Organisms"
9:40 am - 9:50 am
Discussion
9:50 am - 10:20 am
"Multitarget Anti-Malarial Polyamine Analogues: Resisting Resistance"
10:20 am - 10:30 am
Discussion
10:30 am - 10:55 am
Coffee Break
10:55 am - 11:25 am
"The Clinical Development of SBP-101, a Polyamine Analogue for the Treatment of Pancreatic Cancer and Pancreatitis"
11:25 am - 11:35 am
Discussion
11:35 am - 12:05 pm
"Developing Drugs Targeting the Polyamine Pathway to Treat Cancer Risk Factors"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Polyamine Inhibition of eIF5A Induces Ribosome Queuing and Promotes Near Cognate Initiation on the AZIN1 mRNA"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Keynote Session: Why Can't Eukaryotic Cells Live Without Polyamines?
5:30 pm - 5:40 pm
"Polyamines in Vinegar Are Key Compounds for Effective Trapping of Spotted Wing Drosophila "
5:40 pm - 5:45 pm
Discussion
5:45 pm - 5:55 pm
"In Silico Identification of Polyamine Metabolic Dysregulation Across Cancers"
5:55 pm - 6:00 pm
Discussion
6:00 pm - 6:10 pm
"Polyamine Uptake: A Potential Therapeutic Target for Schistosomiasis"
6:10 pm - 6:15 pm
Discussion
6:15 pm - 6:20 pm
Introduction by Discussion Leader
6:20 pm - 7:05 pm
"Why Can't Eukaryotic Cells Live Without Polyamines?"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
"Closing Remarks: Historical and Future Perspectives"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure