Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
7:40 pm - 8:05 pm
"Polyamine Synthesis and Hypusination Prepare Fibroblasts for Collagen Production and Proliferation after Lung Injury"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
"Dysregulations in Putrescine Metabolism Drive Hepatic Fibrosis in MASH"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
"The Role of Spermidine in Cancer Immunotherapy and Aging"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Roles of Polyamines in Degenerative Disorders
9:00 am - 9:25 am
"Polyamines as Pathogenic Catalysts and Therapeutic Targets in Diabetes"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Transcriptomic Analysis Highlights the Therapeutic Potential of Spermidine in ALS Mouse Models"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Group Photo / Coffee Break
10:35 am - 11:00 am
"Spermidine: A Path to Better Rest?"
11:00 am - 11:10 am
Discussion
11:10 am - 11:35 am
"ATP13A2 LOSS of Function and Polyamine Deficiency Cause Epigenetic Reprogramming of Astrocytes to an Inflammatory State Toxic to Dopaminergic Neurons"
11:35 am - 11:45 am
Discussion
11:45 am - 12:00 pm
Short Talk Selected from Poster Abstracts
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Hypusination and Translation
7:30 pm - 7:55 pm
"Molecular Analysis of the Hypusine Modification on eIF5A"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Structural Biology of (Deoxy)Hypusination"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Roles of the Polyamine-Hypusine Circuit in the Development and Malignant Transformation of B-Cells"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Polyamine-Based Therapies and Clinical Trials
9:00 am - 9:25 am
"Reading the Signals: Spermidine’s Impact on Autophagy in Humans"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Turning Up the Heat: Reprogramming the Tumor Immune Microenvironment via Polyamine Depletion"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 11:00 am
"Polyamines Wobble a Proliferative Switch in Neuroblastoma: Therapeutic Implications"
11:00 am - 11:10 am
Discussion
11:10 am - 11:35 am
"Polyamines Under Stress: Autophagy and Polyamine-Metabolism in Stress-Related Diseases"
11:35 am - 11:45 am
Discussion
11:45 am - 12:00 pm
Short Talk Selected from Poster Abstracts
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Genetic Disorders and Polyamines
7:30 pm - 7:55 pm
"Clinical Aspects of DHPS Deficiency"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Bachmann-Bupp Syndrome: Clinical and Biochemical Analysis of DFMO Treatment"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"How Spermine Synthase Deficiency Impairs Bone Formation"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Polyamine Innovations: Food, Microbiota, and Dynamic Enzyme Mechanisms
9:00 am - 9:25 am
"Development of Novel Foods to Increase the Supply of Polyamines"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Microbiota and Polyamines: Crosstalk That Fuels Cancer"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 11:00 am
"A Dynamic Dehydrogenase: Progress Toward a Kinetic Mechanism for Carboxyspermidine Dehydrogenase"
11:00 am - 11:10 am
Discussion
11:10 am - 11:35 am
"Genetically Encoded Fluorescent Sensors for Polyamines"
11:35 am - 11:45 am
Discussion
11:45 am - 12:00 pm
Short Talk Selected from Poster Abstracts
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
New Roles of Polyamines in Infectious Diseases and Cellular Transport
7:30 pm - 7:55 pm
"Astrocytes on Cleanup Duty: Mopping Up Polyamines for Neural Health"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Advancements in Polyamine Metabolism: Leveraging the DAB-APT Assay to Combat Infectious Diseases, Cancer, and Other Disorders"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Polyamines as Regulators of Immune Responses to Bacterial Infection"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
In Memory of Dr. Patrick Woster and Dr. Autar Mattoo: Polyamine Modulation from Inhibitors to Physiological Adaptations
9:00 am - 9:25 am
"Hypusination and Polyamine-Related Salt Stress Responses of Plants"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Rational Discovery of Inhibitors and Degraders of the Polyamine Deacetylase HDAC10"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 11:00 am
"Development of Novel Arginine-Polyamine Pathway Inhibitors for the Treatment of ADPKD"
11:00 am - 11:10 am
Discussion
11:10 am - 11:35 am
"Mechanisms of Spermidine Action in the Aging Brain"
11:35 am - 11:45 am
Discussion
11:45 am - 12:00 pm
Short Talk Selected from Poster Abstracts
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Polyamines and Cancer Biology
7:30 pm - 7:40 pm
Short Talk Selected from Poster Abstracts
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Short Talk Selected from Poster Abstracts
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Short Talk Selected from Poster Abstracts
8:10 pm - 8:15 pm
Discussion
8:15 pm - 9:00 pm
"Targeting Polyamine Dysregulation in Cancer"
9:00 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"50 Years of Polyamine Gordon Conferences"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure