| SATURDAY |
| 2:00 pm | Check-In Begins |
| 3:00 pm - 3:15 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Co-Chairs Andrew Goodwin (Johns Hopkins University) and Takeshi Uemura (University of Arizona) |
| 3:15 pm - 4:00 pm | KEYNOTE SESSION |
| Discussion Leaders: Andrew Goodwin (Johns Hopkins University) and Takeshi Uemura (University of Arizona) |
| 3:15 pm - 3:45 pm | Laurence J. Marton (Progen Pharmaceuticals)
"Challenges in Applying the Science of the Polyamines to the Clinic" |
| 3:45 pm - 4:00 pm | Discussion |
| 4:00 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | BIOCHEMICAL, STRUCTURAL, AND ENZYMATIC STUDIES OF POLYAMINE METABOLIC PATHWAYS |
| Discussion Leader: Tony Michael (Institute of Food Research, Norwich, UK) |
| 7:30 pm - 7:45 pm | Leo Kurian (University of Cologne)
"Mechanism of polyamine-controlled programmed +1 ribosomal frameshifting in decoding yeast ODC antizyme mRNA" |
| 7:45 pm - 7:50 pm | Discussion |
| 7:50 pm - 8:05 pm | Rajtilak Majumdar (University of New Hampshire)
"The SAMDC gene family: Their tissue-specific expression and response to abiotic stress treatments" |
| 8:05 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:25 pm | Tania Silva (University of Coimbra)
"Conformational Studies on Modified Polyamines by Vibrational Spectroscopy" |
| 8:25 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:45 pm | Frances Shaw (Institute of Food Research)
"Horizontal gene transfer between bacteria, phage, archaea, eukaryotes and viruses in the evolution of homospermidine biosynthesis" |
| 8:45 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:05 pm | Kyohei Higashi (Chiba University)
"Identification and Function of Amino Acid Residues on PotB and PotC Involved in Spermidine Uptake Activity" |
| 9:05 pm - 9:10 pm | Discussion |
| 9:10 pm - 9:25 pm | Valentina Battaglia (University of Padua)
"Biogenic Amines as regulators of mitochondrial functions: Roles of Agmatine" |
| 9:25 pm - 9:30 pm | Discussion |
| 9:30 pm - 12:00 am | Reception |
| SUNDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | APPLICATIONS OF POLYAMINE RESEARCH IN HUMAN HEALTH AND DISEASE |
| Discussion Leader: Susan Gilmour (Lankenau Institute, Wynnewood, PA) |
| 9:00 am - 9:15 am | Shannon Nowotarski (Pennsylvania State University)
"Regulation of ornithine decarboxylase (ODC) by the mRNA binding protein, HuR, in skin carcinogenesis" |
| 9:15 am - 9:20 am | Discussion |
| 9:20 am - 9:35 am | Johanna Welch (Lund Univeristy)
"Hypoxia-mediated induction of the polyamine system provides opportunities for tumor growth inhibition by combined targeting of vascular endothelial growth factor and ornithine decarboxylase" |
| 9:35 am - 9:40 am | Discussion |
| 9:40 am - 9:55 am | Jennifer Archer (University of Central Florida)
"Polyamine Transport Inhibitors and Cancer Therapy" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am - 10:15 am | Tacha Plym Forshell (Umea University)
"Spermidine Synthase is directly regulated by Myc and can be targeted in treatment of B-cell lymphomas" |
| 10:15 am - 10:20 am | Discussion |
| 10:20 am | Coffee Break |
| 10:50 am - 11:05 am | Jandeli Niemand (University of Pretoria)
"Characterization of polyamine transport in the malaria parasite, Plasmodium falciparum" |
| 11:05 am - 11:10 am | Discussion |
| 11:10 am - 11:25 am | Theresa Carr (Pennsylvania State University)
"Antizyme represses MEK mediated epidermal proliferation and stem cell expansion" |
| 11:25 am - 11:30 am | Discussion |
| 11:30 am - 11:45 am | Helena Cirenajwis (Lund University)
"A putative breast cancer stem cell population in the Herceptin resistant breast cancer cell line JIMT-1 decreases after treatment with PG11047" |
| 11:45 am - 11:50 am | Discussion |
| 11:50 am - 12:05 pm | Courtney Luke (Columbia University)
"Hairless and putrescine form a negative feedback loop that plays a role in UVB induced carcinogenesis" |
| 12:05 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:30 pm | GRS Evaluation |
| (Discuss potential for future Polyamines GRS; fill out evaluation forms; select GRS talks to be presented at the GRC conference) |
| 12:30 pm | Lunch |
| 1:30 pm - 3:30 pm | Poster Session II |
| 3:30 pm | Gordon Research Seminar ends. For those attending the associated Gordon Research Conference, please check in at the GRC Office beginning at 4:00 pm. |