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Polyamines (GRS)

Gordon Research Seminar

Polyamines in Cellular Metabolism, Cancer Biology, Plants and Pathogens

June 22 - 23, 2019

Chairs

and

Waterville Valley

56 Packard's Road

Waterville Valley, New Hampshire, United States

Venue and Travel Information

Conference Description

The 2019 Gordon Research Seminar (GRS) on Polyamines is a unique forum for graduate students, post-doctoral scholars and other early stage researchers with similar education and experiences to present and exchange new data and cutting edge ideas. Featuring discussions led by world-renowned leaders in the Polyamine field, the 2019 GRS program will offer a wide scope of groundbreaking Polyamine research topics, from the role and regulation of polyamines in cellular metabolism to polyamine-targeted therapies in human health and disease. Bringing together students, young scientists, and senior principal investigators from around the world, the Polyamine GRS is an exclusive opportunity for young investigators to gain mentorship, build collaborative networks, and to prepare for active participation in the Polyamine GRC.

Related Meeting

This GRS will be held in conjunction with the "Polyamines" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
2:00 pm - 5:00 pm	Arrival and Check-in
3:30 pm - 3:45 pm	Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm	Polyamines in Cellular Metabolism, Human Health and Disease Discussion Leader:
3:45 pm - 3:50 pm	Opening Remarks
3:50 pm - 4:05 pm	"Effect of a Lifestyle Intervention Program with Energy-Restricted Mediterranean Diet and Exercise on the Serum Polyamine Metabolome in Individuals at High Cardiovascular Risk"
4:05 pm - 4:10 pm	Discussion
4:10 pm - 4:25 pm	"SMOX, p21 and Non-Coding RNAs in the Physiopathology of Skeletal Muscle"
4:25 pm - 4:30 pm	Discussion
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Polyamines in Cellular Metabolism, Human Health and Disease (continued) / Keynote Session: Implications in Polyamine Research Discussion Leader:
7:30 pm - 7:45 pm	"Regulation of the P-Type ATPase ATP13A3 for Polyamine Transport in Pancreatic Cancers"
7:45 pm - 7:50 pm	Discussion
7:50 pm - 8:05 pm	"Leveraging Polyamine Metabolic Stress to Enhance Sensitivity to Epigenetic Therapy for Prostate Cancer"
8:05 pm - 8:10 pm	Discussion
8:10 pm - 8:25 pm	"Polyamine Biosynthetic Metabolic Dysregulation: Targeting and the Adaptive Response"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:45 pm	"DFMO and 5-Azacytidine Increase M1 Macrophages in the Tumor Microenvironment of an Ovarian Cancer Mouse Model"
8:45 pm - 8:50 pm	Discussion
8:50 pm - 9:25 pm	"Implications in Polyamine Research: Past, Present and Future"
9:25 pm - 9:30 pm	Discussion
Sunday
7:30 am - 8:30 am	Breakfast
9:00 am - 11:00 am	Plants, Parasites and Other Microorganisms Discussion Leader:
9:00 am - 9:10 am	Introduction by Discussion Leader
9:10 am - 9:25 am	"Polyamines: Paramount for Parasite Proliferation and Persistence"
9:25 am - 9:30 am	Discussion
9:30 am - 9:45 am	"Genetic and Biochemical Analysis of Carboxyspermidine Decarboxylase of the Prominent Intestinal Microbiota Species Bacteroides thetaiotaomicron"
9:45 am - 9:50 am	Discussion
9:50 am - 10:05 am	"Targeting Polyamine Metabolism for Control of Fungal Pathogenesis and Increasing Host Resistance During the Maize-Aspergillus flavus Interaction"
10:05 am - 10:10 am	Discussion
10:10 am - 10:25 am	"The Macrophage Reverse Transsulfuration Pathway Mediates Helicobacter pylori Immunopathogenesis by Regulating Polyamine Synthesis"
10:25 am - 10:30 am	Discussion
10:30 am - 10:45 am	"Characterization of the Gamma-Glutamylpolyamine Synthetase GlnA3 in Mycobacterium tuberculosis as a Potential Drug Target"
10:45 am - 10:50 am	Discussion
10:50 am - 11:00 am	General Discussion
11:00 am - 12:30 pm	Poster Session Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm	Lunch
1:30 pm - 2:30 pm	Polyamines in Therapeutics: Targets and Applications Discussion Leader:
1:30 pm - 1:45 pm	"Development of Compounds Which Inhibit Polyamine Trafficking in Pancreatic Cancer Cells"
1:45 pm - 1:50 pm	Discussion
1:50 pm - 2:05 pm	"Effectiveness of Novel Therapeutics Targeting Polyamine Biosynthesis and Transport in Pancreatic Tumor Progression"
2:05 pm - 2:10 pm	Discussion
2:10 pm - 2:30 pm	General Discussion
2:30 pm - 3:00 pm	Evaluation Period Fill in GRS Evaluation Forms
3:00 pm	Seminar Concludes

Contributors

Susan and Neil Gilmour

John and Marika Cleveland

Bob Casero

Otto and Nicole Phanstiel

Patrick M. Woster

Gene and Sandy Gerner

Funding for this conference was made possible (in part) by 1R13CA239582-01 from the National Cancer Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

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Conference History Polyamines

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