Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Keynote Session: Polyamines Across Scales
3:45 pm - 3:50 pm
Introduction by Discussion Leader
3:50 pm - 4:20 pm
"Dichotomous Roles of Polyamines in Gastrointestinal Inflammation and Cancer: The Good, the Bad and the Ugly"
4:20 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Polyamines from Cells to Organisms
7:30 pm - 7:45 pm
"Novel Drug Targets in Mycobacterium tuberculosis Polyamine Metabolism Essential for Survival in Human Macrophages"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
"Inhibition of ODC with DFMO Influences Gut Microbiota and Microbial Metabolites in Autoimmune Diabetes"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Gut Microbes Utilize Soy-Derived Indigestible Peptides as a Nutrient Source Resulting in the Production of Putrescine"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"A Noncanonical Polyamine from Gut Bacteria Antagonizes Host Mitochondrial Function"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"The Interplay of Polyamines, Histone Modifications, and Lifespan Extension Under Methionine Restriction in Yeast"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Identifying and Targeting the Oncogenic Function of Metabolites in Colorectal Cancer"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Emerging Directions of Polyamine Research
9:00 am - 9:15 am
"The Art of Measuring Polyamine Uptake: Methods That Matter"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
"Targeting ATP13A3-Dependent Polyamine Transport for Cancer Therapy"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
"Molecular Analysis of ATP13A3 as Polyamine Transporter and Drug Target"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
"Beyond Kinase Activity: ERK1/2’s Role in the Regulation of Deoxyhypusination"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
"A Novel Autophagy-Inducing Spermidine Derivative"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
"Deciphering the Impact of Polyamine Metabolism in Heart Failure"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Towards Therapeutic Applications of Polyamines
1:30 pm - 1:45 pm
"Polyamines as a Therapeutic Target: Impact on Metabolism and Mitochondrial Function in Leishmania Parasites"
1:45 pm - 1:50 pm
Discussion
1:50 pm - 2:05 pm
"Redox-Responsive Spermine Prodrugs to Treat Snyder-Robinson Syndrome"
2:05 pm - 2:10 pm
Discussion
2:10 pm - 2:25 pm
"Non-Coding RNAs and ALS: Insights into Pathogenic Mechanisms and the Modulatory Effects of Spermidine"
2:25 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes