Sunday
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2:00 pm - 9:00 pm |
Arrival and Check-in
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6:00 pm - 7:00 pm |
Dinner
|
7:30 pm - 7:40 pm |
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
|
7:40 pm - 9:30 pm |
Keynote Session: Spliceosome Structure
Discussion Leader: Tracy Johnson (University of California, Los Angeles, USA)
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7:40 pm - 8:20 pm |
Kiyoshi Nagai (MRC Laboratory of Molecular Bioloogy, United Kingdom)
"CryoEM Snapshots of the Spliceosome Provides Insights into the Assembly and Catalytic Mechanisms of the Spliceosome"
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8:20 pm - 8:30 pm |
Discussion
|
8:30 pm - 8:50 pm |
Anna Marie Pyle (Yale University, USA)
"Protein-Facilitated Group II Intron Splicing: Implications for Spliceosomal Processing and Retrotransposition"
|
8:50 pm - 9:00 pm |
Discussion
|
9:00 pm - 9:20 pm |
Manuel Ares (University of California, Santa Cruz, USA)
"After the Thrill Is Gone: Residual Activities of the Post-Catalytic Spliceosome"
|
9:20 pm - 9:30 pm |
Discussion
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Monday
|
7:30 am - 8:30 am |
Breakfast
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9:00 am - 12:30 pm |
Splicing Mechanisms
Discussion Leader: Karla Neugebauer (Yale University, USA)
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9:00 am - 9:20 am |
Soo-Chen Cheng (Academia Sinica, Taiwan)
"Insights into Splicing Catalytic Steps"
|
9:20 am - 9:30 am |
Discussion
|
9:30 am - 9:50 am |
Aaron Hoskins (University of Wisconsin-Madison, USA)
"Mechanisms of Splice Site and Branchsite Selection by the Spliceosome"
|
9:50 am - 10:00 am |
Discussion
|
10:00 am - 10:20 am |
Douglas Black (University of California, Los Angeles, USA)
"The Role of RBFOX Proteins in the Cytoplasm"
|
10:20 am - 10:30 am |
Discussion
|
10:30 am - 11:00 am |
Coffee Break
|
11:00 am - 11:20 am |
Charles Query (Albert Einstein College of Medicine, USA)
"Using Orthogonal Spliceosomes to Reprogram Substrate Recognition"
|
11:20 am - 11:30 am |
Discussion
|
11:30 am - 11:50 am |
Jonathan Staley (University of Chicago, USA)
"The Role of DEAH Box ATPases in Splicing"
|
11:50 am - 12:00 pm |
Discussion
|
12:00 pm - 12:10 pm |
Selected from Poster Abstracts: Kathleen Hall (Washington University School of Medicine in St. Louis, USA)
"Molecular Principles Underlying Dual RNA Specificity in the Drosophila SNF Protein"
|
12:10 pm - 12:15 pm |
Discussion
|
12:15 pm - 12:25 pm |
Selected from Poster Abstracts: Alan Zahler (University of California, Santa Cruz, USA)
"PRP8 and the Tri-snRNP 27K Protein Engage in Cryptic 5'ss Choice"
|
12:25 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:00 pm |
Free Time
|
3:00 pm - 4:00 pm |
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Yue Wan (Genome Institute of Singapore, A*STAR, Singapore) and Tracy Johnson (University of California, Los Angeles, USA)
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
|
7:30 pm - 9:30 pm |
Technologies to Study RNA Biology
Discussion Leader: Angela Brooks (University of California, Santa Cruz, USA)
|
7:30 pm - 7:50 pm |
Gary Schroth (Illumina, Inc, USA)
"Recent Advances in Next-Generation Sequencing Methods for RNA Analysis"
|
7:50 pm - 8:00 pm |
Discussion
|
8:00 pm - 8:20 pm |
L. Stirling Churchman (Harvard Medical School, USA)
"Exploring Co-Transcriptional Processes with the Nascent Transcriptome"
|
8:20 pm - 8:30 pm |
Discussion
|
8:30 pm - 8:50 pm |
Benjamin Blencowe (University of Toronto, Canada)
"CRISPR-Cas9 Interrogation of Alternative Splicing Regulatory Networks"
|
8:50 pm - 9:00 pm |
Discussion
|
9:00 pm - 9:10 pm |
Selected from Poster Abstracts: Rocky Cheung (University of California, Los Angeles, USA)
"A Multiplexed Assay for Exon Recognition Reveals that an Unappreciated Fraction of Rare Genetic Variants Cause Large-Effect Disruptions to Splicing"
|
9:10 pm - 9:15 pm |
Discussion
|
9:15 pm - 9:25 pm |
Selected from Poster Abstracts: Weijin Xu (Brandeis University, USA)
"RiboTRIBE: Using RNA Editing to Monitor Translational Regulation"
|
9:25 pm - 9:30 pm |
Discussion
|
Tuesday
|
7:30 am - 8:30 am |
Breakfast
|
9:00 am - 12:30 pm |
Translation Regulation
Discussion Leader: Melissa Moore (Moderna Therapeutics, USA)
|
9:00 am - 9:20 am |
Stephen Floor (University of California, San Francisco, USA)
"Translating Human Neuronal Differentiation"
|
9:20 am - 9:30 am |
Discussion
|
9:30 am - 9:50 am |
Rachel Green (Howard Hughes Medical Institute / Johns Hopkins School of Medicine, USA)
"Ribosome Rescue and Homeostasis in Eukaryotic Cells"
|
9:50 am - 10:00 am |
Discussion
|
10:00 am - 10:20 am |
Joel McManus (Carnegie Mellon University, USA)
"Functional Impact of Yeast Transcript Leaders and uORFs"
|
10:20 am - 10:30 am |
Discussion
|
10:30 am - 11:00 am |
Coffee Break
|
11:00 am - 11:20 am |
Ina Hollerer (University of California, Berkeley, USA)
"Disentangling the Roles of Transcriptional and Translational Regulation During Conditions of Cellular Change"
|
11:20 am - 11:30 am |
Discussion
|
11:30 am - 11:50 am |
Lynne Maquat (School of Medicine and Dentistry, University of Rochester Medical Center, USA)
"Transcriptional Co-Activator PGC-1alpha Contains a Novel CBP80-Binding Motif that Orchestrates Efficient Target-Gene Expression"
|
11:50 am - 12:00 pm |
Discussion
|
12:00 pm - 12:10 pm |
Selected from Poster Abstracts: Alexander Burroughs (Computational Biology Branch, NCBI/NLM, NIH, USA)
"Identification and Characterization of the Long-Missing Eukaryotic Ribosome Quality Control Release Factor in the Vms1/ANKZF1 Protein"
|
12:10 pm - 12:15 pm |
Discussion
|
12:15 pm - 12:25 pm |
Selected from Poster Abstracts: Junjie Guo (Yale University, USA)
"Molecular Determinants of ALS/FTD-Associated RAN Translation"
|
12:25 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
|
7:30 pm - 9:30 pm |
Non-Coding RNAs and Their Protein Interactors
Discussion Leader: Lynne Maquat (School of Medicine and Dentistry, University of Rochester Medical Center, USA)
|
7:30 pm - 7:50 pm |
Jeannie Lee (Massachusetts General Hospital, USA)
"Xist RNA and the Mechanisms of Whole-Chromosome Silencing"
|
7:50 pm - 8:00 pm |
Discussion
|
8:00 pm - 8:20 pm |
Amy Pasquinelli (University of California, San Diego, USA)
"Tell-Tale Poly(A) Tails"
|
8:20 pm - 8:30 pm |
Discussion
|
8:30 pm - 8:50 pm |
Oliver Rando (University of Massachusetts Medical School, USA)
"Small RNA Dynamics in the Mammalian Germline"
|
8:50 pm - 9:00 pm |
Discussion
|
9:00 pm - 9:10 pm |
Selected from Poster Abstracts: Patricia Garcia (Princeton University, USA)
"Pop1, Pop6 and Pop7, Subunits of RNase P/MRP, Co-Purify with Telomerase and Affect Telomerase RNA In Vivo"
|
9:10 pm - 9:15 pm |
Discussion
|
9:15 pm - 9:25 pm |
Selected from Poster Abstracts: Daniel Dominguez (Massachusetts Institute of Technology, USA)
"An Aggressive Class of a Kidney Cancer with High Levels of Intron-Containing Transcripts"
|
9:25 pm - 9:30 pm |
Discussion
|
Wednesday
|
7:30 am - 8:30 am |
Breakfast
|
9:00 am - 12:30 pm |
RNA and Disease
Discussion Leader: Rachel Green (Howard Hughes Medical Institute / Johns Hopkins School of Medicine, USA)
|
9:00 am - 9:20 am |
Angela Brooks (University of California, Santa Cruz, USA)
"Somatic Mutations in Cancer Genomes that Alter Post-Transcriptional Gene Regulation"
|
9:20 am - 9:30 am |
Discussion
|
9:30 am - 9:50 am |
Adrian Krainer (Cold Spring Harbor Laboratory, USA)
"Quantitative Activity Profile and Context Dependence of All Human 5' Splice Sites"
|
9:50 am - 10:00 am |
Discussion
|
10:00 am - 10:20 am |
Melissa Moore (Moderna Therapeutics, USA)
"RNA as Medicine"
|
10:20 am - 10:30 am |
Discussion
|
10:30 am - 11:00 am |
Group Photo / Coffee Break
|
11:00 am - 11:20 am |
Peter Smith (H3 Biomedicine, USA)
"Modulating the SF3b Complex in Spliceosome Mutant Cancers"
|
11:20 am - 11:30 am |
Discussion
|
11:30 am - 11:50 am |
Matthew Disney (The Scripps Research Institute, USA)
"Translating RNA Sequence into Lead Small Molecule Medicines"
|
11:50 am - 12:00 pm |
Discussion
|
12:00 pm - 12:20 pm |
Gene Yeo (University of California, San Diego, USA)
"RNA-Targeting Applications with CRISPR-Cas"
|
12:20 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 5:30 pm |
Poster Session
|
5:30 pm - 7:30 pm |
Interesting RNA Biology in Weird Biological Settings
Discussion Leader: Brenton Graveley (UConn Health, USA)
|
5:30 pm - 5:50 pm |
Peter Baumann (Johannes Gutenberg University Mainz, Germany)
"Telomerase RNA Processing and Quality Control"
|
5:50 pm - 6:00 pm |
Discussion
|
6:00 pm - 6:20 pm |
Julia Salzman (Stanford University, USA)
"Transcriptional and Post-Transcriptional Regulation of circRNAs"
|
6:20 pm - 6:30 pm |
Discussion
|
6:30 pm - 6:50 pm |
Jin Billy Li (Stanford University, USA)
"dsRNA Sensing Mediated by ADAR1 RNA Editing in Innate Immunity"
|
6:50 pm - 7:00 pm |
Discussion
|
7:00 pm - 7:20 pm |
Anita Hopper (The Ohio State University, USA)
"Conserved Roles of Mitochondrial Outer Membrane Proteins in Pre-RNA Processing"
|
7:20 pm - 7:30 pm |
Discussion
|
8:00 pm - 9:00 pm |
Dinner
|
Thursday
|
7:30 am - 8:30 am |
Breakfast
|
8:30 am - 9:00 am |
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
|
9:00 am - 12:30 pm |
RNA Modification and Localization
Discussion Leader: Anita Hopper (The Ohio State University, USA)
|
9:00 am - 9:20 am |
Nicholas Conrad (University of Texas Southwestern Medical Center, USA)
"Posttranscriptional Mechanisms to Control Metabolic Gene Expression"
|
9:20 am - 9:30 am |
Discussion
|
9:30 am - 9:50 am |
Wendy Gilbert (Yale University, USA)
"Regulating Gene Expression Through RNA Pseudouridylation"
|
9:50 am - 10:00 am |
Discussion
|
10:00 am - 10:20 am |
Daniel Larson (National Cancer Insitute, NIH, USA)
"Splice Site Selection in Long Human Introns Revealed by Single-Molecule Imaging in Living Cells"
|
10:20 am - 10:30 am |
Discussion
|
10:30 am - 11:00 am |
Coffee Break
|
11:00 am - 11:20 am |
Tao Pan (University of Chicago, USA)
"m6A and Co-Transcriptional Regulation of Alternative Splicing"
|
11:20 am - 11:30 am |
Discussion
|
11:30 am - 11:50 am |
Geraldine Seydoux (John Hopkins University School of Medicine, USA)
"Regulation of RNA Granule Assembly by Intrinsically-Disordered Proteins"
|
11:50 am - 12:00 pm |
Discussion
|
12:00 pm - 12:10 pm |
Selected from Poster Abstracts: Yunsun Nam (University of Texas Southwestern Medical Center, USA)
"Structural Basis for S-Adenosylmethionine Sensing by METTL16"
|
12:10 pm - 12:15 pm |
Discussion
|
12:15 pm - 12:25 pm |
Selected from Poster Abstracts: Boxuan Zhao (Stanford University, USA)
"Specialized Guides of m6A Functions: YTHDF Reader Proteins and Their Mechanisms"
|
12:25 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
|
7:30 pm - 9:30 pm |
Splicing Regulatory Mechanisms
Discussion Leader: Douglas Black (University of California, Los Angeles, USA)
|
7:30 pm - 7:50 pm |
Karla Neugebauer (Yale University, USA)
"Coordination of RNA Processing Events In Vivo"
|
7:50 pm - 8:00 pm |
Discussion
|
8:00 pm - 8:20 pm |
Tom Cooper (Baylor College of Medicine, USA)
"The Impact of Conserved Developmentally Regulated Alternative Splicing in Mice"
|
8:20 pm - 8:30 pm |
Discussion
|
8:30 pm - 8:40 pm |
Selected from Poster Abstracts: Ana Fiszbein (Massachusetts Institute of Technology, USA)
"Splicing-Dependent Regulation of Transcription Start Sites"
|
8:40 pm - 8:45 pm |
Discussion
|
8:45 pm - 8:55 pm |
Selected from Poster Abstracts: Melissa Hale (University of Florida, USA)
"Co-Regulation of Alternative Splicing by MBNL and RBFOX"
|
8:55 pm - 9:00 pm |
Discussion
|
9:00 pm - 9:20 pm |
Kristen Lynch (University of Pennsylvania, USA)
"Alternative Splicing and Regulation of the Immune System"
|
9:20 pm - 9:30 pm |
Discussion
|
Friday
|
7:30 am - 8:30 am |
Breakfast
|
9:00 am |
Departure
|