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Drug Carriers in Medicine and Biology
Gordon Research Conference

Understanding Physiological Barriers to Inform Drug Carrier Design

Dates

August 7-12, 2016

Location

Waterville Valley
Waterville Valley, NH

Organizers

Chairs:
Paula T. Hammond & Jan E. Schnitzer

Vice Chairs:
Jeffrey A. Hubbell & Muthiah Manoharan

Meeting Description

The 2016 Gordon Conference on Drug Carriers in Medicine and Biology builds on a rich tradition encompassing biological, physical and engineering principles through clinical application. Top academic investigators and leaders from pharma and biotech will gather to consider the latest advances, as well as critical hurdles requiring coordinated multidisciplinary solutions. The conference provides a dynamic, diverse and collegial environment with academic, industrial and clinical viewpoints. The meeting also provides a unique opportunity for young investigators and junior scientists to present their work in poster format and to exchange ideas with leaders in the field. Select poster presenters will be invited to provide short talks. This conference provides a key platform for discussion and dissemination of critical developments in the design of drug delivery systems to meet the many unique challenges of this field. Addressing these issues requires an interdisciplinary approach that engages basic biology and physiology, chemistry and physics that inform design, as well as engineering and clinical perspectives. The key barriers to delivery are the focus of sessions, ranging from endothelial and epithelial barriers to extracellular matrix and intracellular trafficking. Areas covered in the symposia include cancer, vaccines, infectious disease, nanomedicine approaches, and targeted delivery of drugs to the brain, lung, gut and other organs. The conference will feature cutting edge delivery systems based on polymers, lipids, conjugates, and advanced multicomponent nanoengineered systems containing all types of cargos (proteins, RNA, cells, anti-cancer agents, vaccines, imaging and diagnostic agents). The Waterville Valley Resort provides an excellent setting for opportunities for informal discussions in addition to outdoor recreation activities and a family-friendly setting, which are part of the conference registration. Early application is recommended, as attendance is limited, and the conference has been over-subscribed in the past. The co-chairs welcome applications from junior scientists to attend and present their research findings. Financial support through the conference budget will be made based on poster abstracts within the qualifying period.

Related Meeting

This GRC was held in conjunction with the "Drug Carriers in Medicine and Biology" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmBig Perspectives of Drug Delivery: Cell Biology, Physiology and Engineering Perspectives
Discussion Leader: Paula Hammond (Massachusetts Institute of Technology, USA)
7:40 pm - 8:20 pmHarold Dvorak (Beth Israel Deaconess Medical Center, USA)
"The Tumor Vasculature: Barrier and Potential Target"
8:20 pm - 8:35 pmDiscussion
8:35 pm - 9:15 pmJustin Hanes (Johns Hopkins School of Medicine, USA)
"Nanomedicine: From Basic Concept to Success in the Clinic"
9:15 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmBarriers and Carriers for Delivery Across Epithelial and Extracellular Barriers
Discussion Leaders: Rebecca Carrier (Northeastern University, USA) and David Grainger (University of Utah, USA)
9:00 am - 9:30 amClaus-Michael Lehr (Helmholtz- Zentrum für Infektionsforschung (HZI), Germany)
"Nanocarriers for Overcoming Epithelial and Microbial Barriers"
9:30 am - 9:45 amDiscussion
9:45 am - 10:15 amSamir Mitragotri (University of California, Santa Barbara, USA)
"Ionic Liquids for Delivering Drugs Across the Skin"
10:15 am - 10:30 amDiscussion
10:30 am - 11:00 amGroup Photo / Coffee Break
11:00 am - 11:30 amTheresa Reineke (University of Minnesota, USA)
"From Discovery to Design: Enabling Functional Drug and Nucleic Acid Transport Through Controlled Polymer Synthesis"
11:30 am - 11:45 amDiscussion
11:45 am - 12:15 pmKanjiro Miyata (The University of Tokyo, Japan)
"Ligand-Installed Polymeric Nanocarriers for Targeted Drug and Nucleic Acid Delivery"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmTargets and Carriers to Overcome Endothelial Barriers
Discussion Leader: Jan Schnitzer (Proteogenomics Research Institute for Systems Medicine (PRISM), USA)
7:30 pm - 8:00 pmFitz-Roy Curry (University of California, Davis, USA)
"Transport Mechanisms Determining Uptake and Retention of Therapeutic Agents in Tumors"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmSilvia Muro (University of Maryland, College Park, USA)
"Mechanistic of Intra- and Trans-Endothelial Transport of Nanotherapeutics"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmVladimir Muzykantov (University of Pennsylvania, USA)
"Endothelial Drug Targeting with Sub-Cellular Precision"
9:20 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmBarriers and Carriers in Cancer: Treating Solid Tumors
Discussion Leaders: Nicole Steinmetz (Case Western Reserve University, USA) and Mark Grinstaff (Boston University, USA)
9:00 am - 9:30 amAngela Belcher (Massachusetts Institute of Technology, USA)
"Targeting, Imaging and Treating Tiny Ovarian Tumors"
9:30 am - 9:45 amDiscussion
9:45 am - 10:15 amPete Choyke (National Cancer Institute, NIH, USA)
"Super Enhanced Permeability and Retention After Photoimmunotherapy: Overcoming a Barrier to Nano-Sized Drugs"
10:15 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:30 amGregory Lanza (Washington University in St. Louis, USA)
"Achieving Effective Extravascular Targeted Drug Delivery in Solid and Liquid Cancers"
11:30 am - 11:45 amDiscussion
11:45 am - 12:15 pmMartina Stenzel (University of New South Wales, Australia)
"Unravelling the Influence of the Polymer on the Drug Delivery of Platinum Drugs"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmOvercoming Delivery Barriers to the Brain/BBB
Discussion Leader: Harold Dvorak (Beth Israel Deaconess Medical Center, USA)
7:30 pm - 8:00 pmJennifer Cochran (Stanford University, USA)
"Peptide-Drug Conjugates as Targeted Delivery Vehicles"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmPer-Ola Freskgard (Roche Innovation Center Basel, Switzerland)
"Antibodies for CNS Disorders and the Gateway to the Brain"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmDanica Stanimirovic (National Research Council / University of Ottawa, Canada)
"Targeting Transcytosis Pathways Across the Blood-Brain Barrier: Receptors, Antibodies and Endocytic Sorting Pathways"
9:20 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmChallenges and Frontiers for Nanomedicine and Nanodelivery
Discussion Leaders: Christopher Alabi (Cornell University, USA) and Alexander Kabanov (University of North Carolina at Chapel Hill, USA)
9:00 am - 9:30 amDoo Sung Lee (Sungkyunkwan University, South Korea)
"Acidic-Local Targeting Polymeric Nanocarriers: Theranostic Applications"
9:30 am - 9:45 amDiscussion
9:45 am - 10:15 amBogdan Olenyuk (Proteogenomics Research Institute for Systems Medicine, USA)
"Design and Tumor-Specific Delivery of Small Molecules Targeting Hypoxia-Inducible Transcription"
10:15 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:30 amSuzie Pun (University of Washington, USA)
"Phage, Peptides and Polymers: Targeted Drug Delivery Using Peptide Ligands Identified by Phage Display"
11:30 am - 11:45 amDiscussion
11:45 am - 12:15 pmMaria Vicent (Centro de Investigacion Principe Felipe, Spain)
"Polyglutamates as Versatile Drug Delivery Carriers"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmLate-Breaking Topics / Young Investigator Presentations
Discussion Leader: Muthiah Manoharan (Alnylam Pharmaceuticals, USA)
7:30 pm - 7:40 pmSamantha Berry (Boston University, USA)
"Leveraging Peritoneal Tumor Localization of pH-Responsive Expansile Nanoparticles as a Tool for Fluorescence Guided Surgery and Drug Delivery"
7:40 pm - 7:45 pmDiscussion
7:45 pm - 7:55 pmJulie Champion (Georgia Institute of Technology, USA)
"Protein Nanocarriers for Intracellular Antibody Delivery"
7:55 pm - 8:00 pmDiscussion
8:00 pm - 8:10 pmHonggang Cui (Johns Hopkins University, USA)
"One-Component Nanomedicine"
8:10 pm - 8:15 pmDiscussion
8:15 pm - 8:25 pmChristopher Collins (Purdue University, USA)
"ß-Cyclodextrin Polyrotaxanes as Potential Niemann-Pick Type C Therapeutics: Performance and Structure-Property Relationships"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:40 pmMaria Daniela Garcia-Castillo (Boston Children's Hospital / Harvard Medical School, USA)
"Glycoceramides as a Platform for Drug Delivery of Therapeutic Peptides"
8:40 pm - 8:45 pmDiscussion
8:45 pm - 8:55 pmChristopher Jewell (University of Maryland, College Park, USA)
"Design of Polyelectrolyte Multilayers to Promote Immune Tolerance"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmLiangliang Hao (Massachusetts Institute of Technology, USA)
"Tumor Penetrating RNA Delivery for Therapeutic Benefit of Pancreatic Cancer"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmMillicent Sullivan (University of Delaware, USA)
"Collagen Turnover Stimulated Gene Delivery to Enhance Wound Repair"
9:25 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmBarriers and Carriers for Infectious Disease and Vaccines: Targeting the Immune System
Discussion Leader: Darrell Irvine (Massachusetts Institute of Technology, USA)
9:00 am - 9:30 amMark Prausnitz (Georgia Institute of Technology, USA)
"Drug and Vaccine Delivery Using Microneedle Patches"
9:30 am - 9:45 amDiscussion
9:45 am - 10:00 amJohn Wilson (Vanderbilt University, USA)
"pH-Responsive Polymer Vesicles for Immunotherapeutic Targeting of STING Pathway"
10:00 am - 10:05 amDiscussion
10:05 am - 10:25 amJoe Akin (Novartis Institutes for Biomedical Research, USA)
"Introduction to in-situ vaccination"
10:25 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:30 amMatthias Stephan (Fred Hutchinson Cancer Research Center, USA)
"Biopolymer Implants that Co-Deliver Programmed T Cells and STING Agonists Can Control Tumor Escape Variants"
11:30 am - 11:45 amDiscussion
11:45 am - 12:15 pmLiangfang Zhang (University of California, San Diego, USA)
"Nanotherapeutics and Nanovaccines for Antibiotic-Resistant Bacteria"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmTranslational Approaches to RNA Delivery
Discussion Leader: Kathryn Whitehead (Carnegie Mellon University, USA)
5:30 pm - 6:00 pmDebra Auguste (City College of New York, USA)
"Liposomal Gene Editing and Delivery"
6:00 pm - 6:10 pmDiscussion
6:10 pm - 6:40 pmJudy Lieberman (Harvard Medical School, USA)
"Breaking Out: siRNA Release from Endosomes and Target Gene Knockdown"
6:40 pm - 6:50 pmDiscussion
6:50 pm - 7:20 pmAnil Sood (University of Texas MD Anderson Cancer Center, USA)
"New Approaches for Targeting Tumor Angiogenesis"
7:20 pm - 7:30 pmDiscussion
8:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1R13EB021764-01 from the National Institute of Biomedical Imaging and Bioengineering. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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