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Mammary Gland Biology
Gordon Research Conference

Understudied Areas in Mammary Gland Biology and Breast Cancer

Dates

June 11-16, 2017

Location

Stoweflake Conference Center
Stowe, VT

Organizers

Chairs:
Heide L. Ford & Michael T. Lewis

Vice Chairs:
Christina Scheel & Renee Van Amerongen

Meeting Description

The Gordon Conference in Mammary Gland Biology focuses on normal mammary gland biology and breast cancer biology. This meeting is unique in that it brings together developmental and cancer biologists, with a focus not only on the normal development of the mammary gland and on important issues such as lactation, but also on how the biology of the normal mammary gland informs us about breast cancer biology. The consideration of normal mammary biology in breast cancer biology is a key component of this meeting, as issues such as those highlighted in our meeting below, are relevant to both the developing mammary gland and to breast tumor onset and progression. The 2017 meeting will focus on numerous cutting edge areas in the fields of mammary gland biology and neoplasia. These areas include niches in development and disease, stem cell biology, dormancy in treatment resistance and recurrence, heterogeneity in development and disease, epithelial cell plasticity, stromal determinants of epithelial cell behavior, as well as unconventional mechanisms controlling both organogenesis and carcinogenesis. The meeting has a longstanding tradition of excellent interactions across all levels of investigators, including graduate students and senior faculty members, and is renowned for its energetic discussions of cutting edge science, for interactive poster sessions, and for social time to increase interactions between all members attending. In addition, the meeting includes informal sessions to promote the careers of young scientists ("meet the expert" lunch sessions), with a specific afternoon session dedicated to issues faced by female scientists embarking on a career in science (the GRC "power hour"). The Mammary Gland Biology GRC will be preceded by a Mammary Gland Gordon Research Seminar (GRS) in which graduate students and post-doctoral fellows present their work in a forum prior to the arrival of their mentors. Students and post-docs are encouraged to apply to both meetings.

Related Meeting

This GRC was held in conjunction with the "Mammary Gland Biology" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Niches in Development and Disease
Discussion Leader: Heather Machado (Tulane University School of Medicine, USA)
7:40 pm - 7:55 pmOpening Remarks
7:55 pm - 8:10 pmIntroduction by Discussion Leader
8:10 pm - 9:10 pmAdrian Harris (University of Oxford, United Kingdom)
"Hypoxia, Stem Cells, and Survival"
9:10 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmIdentity, Regulation and Therapeutic Targeting of Stem Cells
Discussion Leader: Carol Sartorius (University of Colorado Anschutz Medical Campus, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:35 amTannishtha Reya (University of California, San Diego, USA)
"Stem Cell Signals in Cancer Heterogeneity and Therapy Resistance"
9:35 am - 9:50 amDiscussion
9:50 am - 10:15 amSridhar Ramaswamy (Massachusetts General Hospital / Harvard Medical School, USA)
"Targeting Sleeping Cancer Cells"
10:15 am - 10:25 amDiscussion
10:25 am - 10:55 amCoffee Break
10:55 am - 11:20 amPaul Macklin (Intelligent Systems Engineering, Indiana University, USA)
"3-D Simulations of Multicellular Systems Biology in Ductal Carcinoma In Situ"
11:20 am - 11:30 amDiscussion
11:30 am - 11:55 amMax Wicha (University of Michigan Medical Center, USA)
"Identification and Targeting Stem Cell Regulatory Pathways"
11:55 am - 12:10 pmDiscussion
12:10 pm - 12:25 pmSelected from Poster Abstracts: Gilbert Smith (Center for Cancer Research, National Cancer Institute, NIH, USA)
"Mammary 'ECM' and Induction of Mammary Development by Non-Mammary Cells: Significance to Multipotent vs Unipotent Mammary Progenitor/Stem Cells"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Joan Brugge (Harvard Medical School, USA) and Tannishtha Reya (University of California, San Diego, USA)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmStromal Determinants of Epithelial Cell Behavior
Discussion Leader: Renee Van Amerongen (University of Amsterdam, The Netherlands)
7:30 pm - 7:40 pmIntroduction by Discussion Leader: Stromal Determinants of Epithelial Cell Behavior
7:40 pm - 8:05 pmKaylee Schwertfeger (University of Minnesota, USA)
"Regulation of Mammary Gland Development and Tumorigenesis by Macrophage-Directed Epithelial"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmValerie Weaver (University of California, San Francisco, USA)
"Matrix Stiffness and Tumor Development"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmSelected from Poster Abstracts: Lin Ma (University of California, San Francisco, USA)
"Ionizing Radiation Promotes Aggressive Tumors that Exhibit Increased Immune Suppression"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmSelected from Poster Abstracts: Adam Watson (University of Arizona Cancer Center, USA)
"Primary Breast Tumor Stiffness Instructs Osteotropic Metastasis via Mechanical Memory"
9:25 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmHeterogeneity in Development and Disease
Discussion Leader: Mohamed Bentires-Alj (University of Basel / University Hospital Basel, Switzerland)
9:00 am - 9:15 amIntroduction by Discussion Leader: Heterogeneity in Development and Disease
9:15 am - 9:40 amJoan Brugge (Harvard Medical School, USA)
"Tracking Functional Heterogeneity and Intratumoral Crosstalk of Triple Negative Breast Cancer Cells"
9:40 am - 9:55 amDiscussion
9:55 am - 10:20 amAnn Ramsdell (University of South Carolina, USA)
"Breast Cancer Heterogeneity, Axial Patterning, and the Mammary Microenvironment"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:25 amMei Zhang (University of Pittsburgh, USA)
"Clonal Cooperativity in Tumor Development"
11:25 am - 11:35 amDiscussion
11:35 am - 12:00 pmDevon Lawson (University of California, Irvine, USA)
"Investigation of Intratumor Heterogeneity in Cancer Progression and Metastasis at the Single-Cell Level"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmSelected from Poster Abstracts: Sai Mun Leong (National University of Singapore, Singapore)
"Regenerable Altruism Drives Chemotolerance in Clonal Cancer Cells"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMammary Epithelial Cell Plasticity
Discussion Leader: Sendurai Mani (University of Texas MD Anderson Cancer Center, USA)
7:30 pm - 7:40 pmIntroduction by Discussion Leader: Mammary Epithelial Cell Plasticity
7:40 pm - 8:05 pmRobert Weinberg (Whitehead Institute for Biomedical Research, USA)
"Molecular Regulation of Tumor-Initiating Cell Plasticity"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmKornelia Polyak (Dana-Farber Cancer Institute, USA)
"Breast Cancer Risk Prediction and Prevention"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmSelected from Poster Abstracts: Jerrica Breindel (Tufts University, USA)
"Epigenetic Mechanisms of Primary Human Mammary Epithelial Cell Dedifferentiation"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmSelected from Poster Abstracts: Zhe Li (Brigham and Women's Hospital, USA)
"BRCA1-Loss Triggers Alteration in the Fates of ER+ and ER- Mammary Luminal Cells"
9:25 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmLactation Biology
Discussion Leader: James McManaman (University of Colorado School of Medicine, USA)
9:00 am - 9:15 amIntroduction by Discussion Leader: Lactation Biology
9:15 am - 9:40 amDarryl Hadsell (Baylor College of Medicine, USA)
"Lessons About Mammary Development and Lactation from Diverse Inbred Mouse Strains"
9:40 am - 9:55 amDiscussion
9:55 am - 10:20 amMalcolm Kennedy (University of Glasgow, United Kingdom)
"The Multifarious Lactation Strategies of Mammals"
10:20 am - 10:35 amDiscussion
10:35 am - 11:05 amCoffee Break
11:05 am - 11:30 amWeston Porter (Texas A&M University, USA)
"Metabolic Adaptation in Lactation: A Model for Breast Cancer Progression?"
11:30 am - 11:45 amDiscussion
11:45 am - 12:00 pmSelected from Poster Abstracts: Jenifer Monks (University of Colorado Anschutz Medical Campus, USA)
"Cell Biology of Lactation: Docking and Stimulated Secretion of Milk Fat Globules"
12:00 pm - 12:05 pmDiscussion
12:05 pm - 12:20 pmRajeev Samant (University of Alabama at Birmingham, USA)
"Errors in Developmental Programming Increase Susceptibility to Metastasis"
12:20 pm - 12:25 pmDiscussion
12:25 pm - 12:30 pmGeneral Discussion: Lactation Biology
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmCellular Dormancy in Development, Treatment Resistance, and Recurrence
Discussion Leader: Pepper Schedin (Oregon Health and Science University, USA)
7:30 pm - 7:40 pmIntroduction by Discussion Leader: Cellular Dormancy in Development, Treatment Resistance, and Recurrence
7:40 pm - 8:05 pmLewis Chodosh (University of Pennsylvania, USA)
"Tumor Dormancy as a Window to Prevent Metastatic Recurrence"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmSenthil Muthuswamy (Beth Israel Deaconess Medical Center / Harvard Medical School, USA)
"Cell Polarity Proteins and Cell Surface Proteome – Impact on Mammary Gland Development and Cancer"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmSelected from Poster Abstracts: Kristina Havas (IFOM - The FIRC Institute of Molecular Oncology, Italy)
"Metabolic Shifts in Residual Breast Cancer Drive Tumor Recurrence"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmSelected from Poster Abstracts: Delphine Merino (Olivia Newton-John Cancer Research Institute, Australia)
"Tracking and Targeting Aggressive Clones in Metastatic Triple Negative Breast Cancer"
9:25 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmUnconventional Mechanisms Controlling Organogenesis and Carcinogenesis
Discussion Leader: Sean Egan (Hospital for Sick Children, Canada)
9:00 am - 9:15 amIntroduction by Discussion Leader: Unconventional Mechanisms Controlling Organogenesis and Carcinogenesis
9:15 am - 9:40 amSol Fereres-Rapoport (University of California, San Francisco, USA)
"Paracrine Signaling in Development and Disease"
9:40 am - 9:55 amDiscussion
9:55 am - 10:20 amBenny Kaipparettu (Baylor College of Medicine, USA)
"Dominance of Mitochondria over the Malignant Phenotype"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:25 amDavid Spector (Cold Spring Harbor Laboratory, USA)
"Long Non-Coding RNAs as Targets in Mammary Cancer Progression"
11:25 am - 11:35 amDiscussion
11:35 am - 12:00 pmMikala Egeblad (Cold Spring Harbor Laboratory, USA)
"Neutrophil Extracellular Traps Promote Breast Cancer Metastasis and Escape from Dormancy"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmSelected from Poster Abstracts: Gat Rauner (Cornell University, USA)
"Unraveling the Mechanisms Behind Species-Resistance to Mammary Cancer"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmKeynote Session: Future Directions in Mammary Gland Research
Discussion Leader: Robert Clarke (University of Manchester, United Kingdom)
7:30 pm - 7:45 pmIntroduction by Discussion Leader: Future Directions in Mammary Gland Research
7:45 pm - 8:45 pmIan Macara (Vanderbilt University Medical Center, USA)
"Mammary Development, Cancer, and Epithelial Homeostasis"
8:45 pm - 9:05 pmDiscussion
9:05 pm - 9:15 pmGeneral Discussion
9:15 pm - 9:30 pmClosing Remarks
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Research reported in this publication was supported by the National Cancer Institute of the National Institutes of Health under Award Number 1R13CA216888-01. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
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