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Metals in Biology
Gordon Research Conference

Biological Metals: Regulation, Catalysis, Medicine, the Environment and Chemical Evolution

Dates

January 22-27, 2017

Location

Four Points Sheraton / Holiday Inn Express
Ventura, CA

Organizers

Chair:
R. David Britt

Vice Chair:
Yi Lu

Meeting Description

Biological metal centers assume numerous important structural and functional roles in association with proteins and nucleic acids, adding chemical diversity to the limited number of amino acids and the even smaller number of nucleic acid bases. This augmented chemical diversity is enhanced by the variety of metal centers employed; including both redox-active and non-redox active metals, single metal binding sites, metals bound by organic cofactors, and multinuclear metal clusters. Understanding how metal ions function in these diverse systems requires multidisciplinary approaches across the broad fields of biology, physics, chemistry/biochemistry, and medicine. The MIB-GRC brings together scientists from diverse backgrounds to foster new collaborations that take advantage of complementary skills. Lectures in the 2017 MIB-GRC cover recent advances in our understanding of the roles of metalloproteins and metal/nucleic acid complexes in cellular signaling, metal ion regulation, and their effects on human health; the evolving biological chemistry of metals from the earth's deep past to the current environment, and metal-centered catalysis by a variety of metalloenzymes, including those crucial in the grand global cycles of hydrogen, nitrogen, and oxygen. In addition to the lectures, poster sessions held to facilitate discussions in an open atmosphere are always a major highlight of the MIB-GRC.

The Gordon Research Seminar (GRS) in Bioinorganic Chemistry, chaired in 2017 by Lauren Rajakovich, is closely associated with the MIB GRC. This meeting typically draws graduate and postdoctoral students from a diverse array of laboratories studying metals in biology. It overlaps with the MIB GRC meeting for one evening session on Thursday, which includes a poster session that allows students to meet and interact with established scientists in their areas of research. We specifically encourage graduate students and postdocs to take advantage of these unique educational opportunities and to participate in either the MIB-GRC conference or the Bioinorganic Chemistry GRS or both.

Yi Lu will chair the 2018 MIB-GRC conference, and Marty Bollinger will chair the 2019 conference.

Related Meeting

This GRC was held in conjunction with the "Bioinorganic Chemistry" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmMetals and Biological Signalling
Discussion Leader: Emily Weinert (Emory University, USA)
7:40 pm - 8:20 pmMichael Marletta (University of California, Berkeley, USA)
"Selective Sensing of Nitric Oxide in Biology"
8:20 pm - 8:35 pmDiscussion
8:35 pm - 9:15 pmThomas O'Halloran (Northwestern University, USA)
"Zinc Receptors, Fluxes and Switches in Control of Cell Fate Decisions"
9:15 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmMetal Ion Homostasis, Proteins and Nucleic Acids
Discussion Leader: Sheila David (University of California, Davis, USA)
9:00 am - 9:30 amVictoria DeRose (University of Oregon, USA)
"Platinum Interactions Across the Cell: New Players and Pathways"
9:30 am - 9:45 amDiscussion
9:45 am - 10:15 amLauren Waters (University of Wisconsin-Oshkosh, USA)
"Regulation of Mn Metabolism in Bacteria: From a Small RNA to a Small Protein to Riboswitches"
10:15 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:30 amWalter Chazin (Vanderbilt University, USA)
"What Are Those Fe-S Clusters Doing in Genome Maintenance Proteins?"
11:30 am - 11:45 amDiscussion
11:45 am - 12:15 pmDavid Giedroc (Indiana University, USA)
"Structural Mechanisms of Transition Metal Homeostasis in Bacteria"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Victoria DeRose (University of Oregon, USA) and Lauren Rajakovich (Pennsylvania State University, USA)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMetal Ion Regulation and Human Health
Discussion Leader: Celia Goulding (University of California, Irvine, USA)
7:30 pm - 8:00 pmAshley Bush (Florey Institute of Neuroscience and Mental Health, Australia)
"Iron and Ferroptosis in Brain Disease"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmGuenter Schwarz (University of Cologne, Germany)
"New Functions of Molybdenum Enzymes in Neurodegeneration and Nitric Oxide Synthesis"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmDianne Newman (California Institute of Technology / Howard Hughes Medical Institute, USA)
"Selective Degradation of an Extracellular Electron Shuttle Abrogates Biofilm Development"
9:20 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmGlobal Chemical Cycles: Nitrogen
Discussion Leader: Yilin Hu (University of California, Irvine, USA)
9:00 am - 9:30 amJonas Peters (California Institute of Technology, USA)
"Synthetic Single-Site Fe N2ases"
9:30 am - 9:45 amDiscussion
9:45 am - 10:15 amSerena Debeer (Max Planck Institute for Chemical Energy Conversion, Germany)
"From FeMoco to FeVco: Heterometal Contributions to Nitrogenase Reactivity"
10:15 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:30 amLeslie Murray (University of Florida, USA)
"Towards Understanding How Metal Ions Cooperate to Activate Dinitrogen"
11:30 am - 11:45 amDiscussion
11:45 am - 12:15 pmLance Seefeldt (Utah State University, USA)
"Light-Driven N2 Reduction Catalyzed by a CdS-Nitrogenase MoFe Protein Hybrid"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmGlobal Chemical Cycles: Energy
Discussion Leader: Anne Jones (Arizona State University, USA)
7:30 pm - 8:00 pmFraser Armstrong (University of Oxford, United Kingdom)
"New Insights into Hydrogenase Catalysis"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmMichael Rose (University of Texas at Austin, USA)
"Functional Models of Mono-[Fe] Hydrogenase Using an Anthracene-Based Ligand Scaffold"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmDaniella Goldfarb (Weizmann Institute of Science, Israel)
"High Spin Metal Ions as Spin Labels for Structural Studies of Proteins In-Vitro and In-Cell"
9:20 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMetalloenzymes: Mechanisms and Models
Discussion Leader: Michael Green (University of California, Irvine, USA)
9:00 am - 9:30 amSteve Yu (Academia Sinica, Taiwan)
"Mechanistic Study for the Stereo-Selective Hydroxylation of [2-2H1,3-2H1]Butanes Catalyzed by Cytochrome P450 BM3 Variants"
9:30 am - 9:45 amDiscussion
9:45 am - 10:15 amJoseph Martin Bollinger (The Pennsylvania State University, USA)
"Emerging Diversity in the Chemistry of Non-Heme Diiron Oxidases and Oxygenases"
10:15 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:30 amJudith Klinman (University of California, Berkeley, USA)
"Lipoxygenase: An Enzyme for All Seasons"
11:30 am - 11:45 amDiscussion
11:45 am - 12:15 pmJohn Peters (Washington State University, USA)
"New Insights into the Mechanism of Electron Bifurcating NADH-Dependent Reduced Ferredoxin:NADP Oxidoreductase"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmMetals and the Environment, from the Deep Past to Today
Discussion Leader: William Casey (University of California, Davis, USA)
7:30 pm - 8:00 pmAlison Butler (University of California, Santa Barbara, USA)
"Biological Wet Adhesion to Mineral Surfaces: Mussels, Siderophores and the Catechol-Cation Synergy"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmDan Rothman (Massachusetts Institute of Technology, USA)
"Nickel-Driven Methanogenic Burst Accompanying Earth's Greatest Extinction"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmThomas Spiro (University of Washington, USA)
"How Bacteria Use a Multicopper Oxidase to Close the Environmental Mn Cycle by Producing MnO2 Biomineral"
9:20 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmWater Oxidation/Oxygen Evolution
Discussion Leader: Richard Debus (University of California, Riverside, USA)
9:00 am - 9:30 amWoodward Fischer (California Institute of Technology, USA)
"A Geobiological Perspective on the Role of Mn in the Evolution of Photosynthesis"
9:30 am - 9:45 amDiscussion
9:45 am - 10:15 amVictor Batista (Yale University, USA)
"Studies of Oxomanganese Complexes for Natural and Artificial Photosynthesis"
10:15 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:30 amNicholas Cox (Australian National University, Australia / Max Planck Institute for Chemical Energy Conversion, Germany)
"High-Field Pulse EPR - A Biophysical Toolbox for the Study of the Oxygen Evolving Complex"
11:30 am - 11:45 amDiscussion
11:45 am - 12:15 pmPetra Fromme (Arizona State University, USA)
"New Insights into the Water Splitting Mechanism of Photosystem II by Time-Resolved Femtosecond Nanocrystallography"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmOxygen, Life in the Balance
Discussion Leader: Kara Bren (University of Rochester, USA)
7:30 pm - 7:40 pmJennifer Kan (California Institute of Technology, USA)
"Directed Evolution of Cytochrome c for Carbon-Silicon Bond Formation: Bringing Silicon to Life"
7:40 pm - 7:45 pmDiscussion
7:45 pm - 7:55 pmKyle Lancaster (Cornell University, USA)
"Cytochrome P460: A 'New' Leak in the Biogeochemical Nitrogen Cycle"
7:55 pm - 8:00 pmDiscussion
8:00 pm - 8:10 pmHannah Shafaat (The Ohio State University, USA)
"Unraveling the Mn/Fe Lipid-Binding Oxidases: An Investigation of Metal Specificity and Cofactor Assembly in R2lox"
8:10 pm - 8:15 pmDiscussion
8:15 pm - 9:15 pmHarry Gray (California Institute of Technology, USA)
"Living with Oxygen"
9:15 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

This material is based upon work supported by the U.S. Department of Energy, Office of Science, Basic Energy Sciences under award number DE-SC0016880. This report was prepared as an account of work sponsored by an agency of the United States Government. Neither the United States government nor any agency thereof, nor any of their employees, makes any warranty, express or implied, or assumes any legal liability or responsibility for the accuracy, completeness, or usefulness of any information, apparatus, product, or process disclosed, or represents that its use would not infringe privately owned rights. Reference herein to any specific commercial product, process, or service by trade name, trademark, manufacturer, or otherwise does not necessarily constitute or imply its endorsement, recommendation, or favoring by the United States Government or any agency thereof. The views and opinions of authors expressed herein do not necessarily state or reflect those of the United States Government or any agency thereof.
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