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Phagocytes
Gordon Research Conference

The Behaviour and Function of Phagocytes in Health and Disease

Dates

May 31 - June 5, 2015

Location

Waterville Valley
Waterville Valley, NH

Organizers

Chair:
Paul Kubes

Vice Chair:
Dianne Cox

Meeting Description

The 2015 Phagocytes Gordon Conference will bring together scientists from around the world to discuss the most recent advances in the area of myeloid cells during homeostasis and during disease. Expert invited speakers will present their latest unpublished research related to the many facets of phagocyte biology. There will be 4 major topics across 4 days starting with phagocytosis, the formation of the phagosome and regulation of these events culminating with a talk on negative regulation of Fc receptors. The second day will discuss the very dynamic placticity of monocytes and macrophage ending with focus on specialized macrophage including a talk on the newly identified GATA6 lineage of macrophage. The third day will focus on new ways of killing of pathogens and dying of immune cells ending with talks about the release and life span of neutrophils using humans as the experimental model. The program will end with some exciting new imaging of innate immunity ranging from visualizing the heart, kidney, lung and other organs and the war between pathogens and myeloid cells. Speakers will also highlight areas of translation to humans. The program is designed to encourage vigorous discussion and the free exchange of ideas. Thus, each scientific session will be chaired by a prominent researcher who will highlight recent progress and knowledge gaps related to each topic, and guide subsequent discussion. As participation of junior scientists is a key goal of the meeting, the conference will also include two interactive sessions for presentation of ~90 posters, and additional speakers will be chosen from among the submitted abstracts. The collegial atmosphere of this conference is exemplified by the shared meals, and the substantial time provided for informal gatherings in the afternoons and evenings to further promote interactions between attendees at all levels. The overall environment is therefore designed to provide multiple opportunities for learning and for the development of exciting collaborations.

To facilitate the participation of students and postdoctoral fellows, the conference will be preceded by a Gordon Research Seminar (GRS). The Phagocytes GRS is planned by and for trainees, and provides an opportunity for our future leaders to present their research via seminars and posters in a supportive and interactive environment. The GRS has been well received and adds substantial value to the Gordon Research Conference experience for these junior investigators.

Related Meeting

This GRC was held in conjunction with the "Phagocytes" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: The Signaling Behind Phagocytosis
Discussion Leader: John Brumell (Hospital for Sick Children, Canada)
7:40 pm - 7:55 pmOpening Remarks
7:55 pm - 8:15 pmIntroduction by Discussion Leader
8:15 pm - 9:05 pmSergio Grinstein (Hospital for Sick Children, Canada)
"Signalling Phagocytosis: Receptors, Kinases and Phosphatases in Space and Time"
9:05 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmFormation of Phagosomes
Discussion Leader: Sergio Grinstein (Hospital for Sick Children, Canada)
9:00 am - 9:25 amRobin M. Yates (University of Calgary, Canada)
"Dynamics of the Phagosomal Lumen"
9:25 am - 9:40 amDiscussion
9:40 am - 10:05 amMary Dinauer (Washington University in St. Louis School of Medicine, USA)
"NADPH Oxidase and Phagosomes"
10:05 am - 10:20 amDiscussion
10:20 am - 10:50 amGroup Photo / Coffee Break
10:50 am - 11:15 amJohn Brumell (Hospital for Sick Children, Canada)
"Efferocytosis, Autophagy and Subversion Mechanisms by Bacteria"
11:15 am - 11:30 amDiscussion
11:30 am - 11:55 amWilliam Nauseef (University of Iowa, USA)
"Necroptosis"
11:55 am - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Aleksandar Ivetic (King's College London, United Kingdom)
"L-Selectin Rolls Forward to Regulate Monocyte Transendothelial Migration"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmLeukocyte Dynamic: Relevance to Humans
Discussion Leader: Samuel Silverstein (Columbia University Medical Center, USA)
7:30 pm - 7:55 pmG. Scott Worthen (University of Pennsylvania, USA)
"The Microbiota and Leukocyte Dynamics"
7:55 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmLeo Koenderman (University Medical Center Utrecht, The Netherlands)
"Separate Neutrophil Subsets Identified by Leukocyte Dynamics and Changes in Functionality: Studies Performed in LPS Challenged Individuals"
8:40 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmSelected from Poster Abstracts: Scott Espenschied (Duke University, USA)
"Gnotobiotc Zebrafish Reveal that Intestinal Microbiota Stimulate Expansion of Leukocytes and Regulate Their Function in Homeostasis and Inflammation"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmSelected from Poster Abstracts: Laura Whitmore (University of Iowa, USA)
"Modulation of Neutrophil Phenotype and Lifespan by Helicobacter pylori"
9:25 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMonocytes and Macrophage in a Changing Environment
Discussion Leader: Dianne Cox (Albert Einstein College of Medicine, USA)
9:00 am - 9:25 amDavid M. Mosser (University of Maryland, USA)
"Regulation of Immune Responses by Macrophages"
9:25 am - 9:40 amDiscussion
9:40 am - 10:05 amGwendalyn Randolph (Washington University in St. Louis, USA)
"Peritoneal Macrophage Homeostasis"
10:05 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:15 amJohn P. Iredale (University of Edinburgh, United Kingdom)
"Macrophages in Resolution of Liver Fibrosis"
11:15 am - 11:30 amDiscussion
11:30 am - 11:55 amDaniel Engel (University Hospital Essen, Germany)
"Crosstalk of Macrophages and Neutrophils in Infections"
11:55 am - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Colin Logie (Radboud University, The Netherlands)
"Epigenetic Programming During Macrophage Differentiation and Training"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmSpecialized Macrophage
Discussion Leader: Gwendalyn Randolph (Washington University in St. Louis, USA)
7:30 pm - 7:55 pmMenno van Lookeren Campagne (Genentech Inc., USA)
"Crosstalk Between Caspases and Autophagy in Macrophages"
7:55 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmHerbert Virgin (Washington University in St. Louis, USA)
"Role of Autophagy Genes in Inflammation and Immunity Through Effects on T Cell Survival and Macrophage-Regulated Innate Immune Tone"
8:40 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmSelected from Poster Abstracts: Kessler McCoy-Simandle (Albert Einstein College of Medicine, USA)
"TNT and Macrophage-Tumor Cell Communication"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmSelected from Poster Abstracts: Evelina Vagesjo (Uppsala University, Sweden)
"Plasmid-Derived CXCL12 Expressed by Ischemic Muscle Improves Functional Regulation of Blood Flow by Directing Macrophages to Perivascular Positions"
9:25 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNew Ways of Killing and Dying
Discussion Leader: Lee-Ann Allen (University of Iowa, USA)
9:00 am - 9:25 amTimo K. Van Den Berg (Sanquin Research, The Netherlands)
"Neutrophils Kill Antibody-Opsonized Cancer Cells by Trogoptosis"
9:25 am - 9:40 amDiscussion
9:40 am - 10:05 amDenisa Wagner (Harvard Medical School, USA)
"Neutrophil Extracellular Traps Fuel Disease"
10:05 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:15 amKodi S. Ravichandran (University of Virginia, USA)
"Unconventional Phagocytes and Their Relevance"
11:15 am - 11:30 amDiscussion
11:30 am - 11:55 amBeth Levine (University of Texas, USA)
"Mechanisms of Autosis, a Form of Autophagic Cell Death"
11:55 am - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Daniel Irimia (Massachusetts General Hospital, Harvard Medical School, USA)
"Human Neutrophil Phagocytosis and Chemotaxis Modulate Each Other, and Control the Bidirectional Neutrophil Trafficking at Sites of Infection"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmRole of Fc Receptors
Discussion Leader: Mary Dinauer (Washington University in St. Louis School of Medicine, USA)
7:30 pm - 7:55 pmMarjolein van Egmond (VU University Medical Center, The Netherlands)
"Phagocyte IgA and IgG Fc Receptors: Two Sides of the Same Coin?"
7:55 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmJeffrey Ravetch (Rockefeller University, USA)
"Diversity of IgG Fc Receptors"
8:40 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmSelected from Poster Abstracts: Sergio Catz (The Scripps Research Institute, USA)
"Molecular Mechanisms Regulating Endosomal Maturation, Signaling and Endosomal-Associated Neutrophil Functions"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmSelected from Poster Abstracts: Michelle Lennartz (Albany Medical College, USA)
"Lipids Orchestrate the Localization and Function PKC-Epsilon During Phagocytosis"
9:25 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmImaging Innate Immunity
Discussion Leader: Paul Kubes (University of Calgary, Canada)
9:00 am - 9:25 amRonald Germain (National Institute of Allergy and Infectious Diseases, NIH, USA)
"Imaging Innate Immunity"
9:25 am - 9:40 amDiscussion
9:40 am - 10:05 amMichael Hickey (Monash University, Australia)
"Imaging Monocyte/Neutrophil Interactions in the Inflamed Glomerulus"
10:05 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:15 amMark J. Miller (Washington University in St. Louis School of Medicine, USA)
"In Vivo Imaging of Phagocyte Trafficking During Infection and Tissue Injury"
11:15 am - 11:30 amDiscussion
11:30 am - 11:55 amTanya N. Mayadas (Brigham and Women's Hospital / Harvard Medical School, USA)
"Regulation of FcgRIIA Mediated Neutrophil Recruitment in Autoimmune Disease"
11:55 am - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Jennifer Stow (Institute for Molecular Bioscience, Australia)
"Macrophage Dorsal Ruffles as Dynamic Platforms for TLR Signaling and Phagocytosis"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmFighting Infections
Discussion Leader: Ronald Germain (National Institute of Allergy and Infectious Diseases, NIH, USA)
7:30 pm - 7:55 pmBryan Yipp (University of Calgary, Canada)
"Imaging Innate Immunity in Lung"
7:55 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmRichard Hanna (La Jolla Institute for Allergy and Immunology, USA)
"Patrolling Monocyte Response to Tumors"
8:40 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmSelected from Poster Abstracts: Alex Marki (La Jolla Institute for Allergy and Immunology, USA)
"Direct Visualization of Neutrophil Tethers and Slings in a Side-View Flow Chamber"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmBas Surewaard (University of Calgary, Canada)
"Studying S. aureus Evasion Mechanisms In Vivo"
9:25 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible [in part] by 1 R13 AI117977-01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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