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Bioorganic Chemistry
Gordon Research Conference

Chemical Approaches for Unraveling Biology

Dates

June 5-10, 2016

Location

Proctor Academy
Andover, NH

Organizers

Chairs:
Carole A. Bewley & Douglas S. Johnson

Vice Chairs:
Paramjit S. Arora & Frank W. Kotch

Meeting Description

The Bioorganic Chemistry Gordon Research Conference (GRC) was established in 1992 with the aim of bringing together diverse scientific disciplines at the interface of chemistry and biology. Attendees from industry, academia and other research institutions convene annually to discuss the latest techniques and approaches that are widely applicable but not limited to bioorganic chemistry within cellular and molecular processes, drug discovery efforts, new target identification and development of interdisciplinary research tools and probes.

The 2016 meeting, which marks the 25th Anniversary of the Bioorganic Chemistry GRC, will broadly focus on the impact of bioorganic chemistry in the development of methods that facilitate new therapeutic strategies and drug discovery. Sessions will include design of new cellular tools to probe biology, chemical approaches that facilitate advances in imaging, recent advances in neuroscience chemical biology, strategies for intractable targets in drug development, new approaches to natural products and antibiotic discovery, peptides and proteins with novel functions, and the importance of glycans in health and disease. Conferees are encouraged to present posters; poster presenters should submit an abstract with their applications on the GRC web site. As this meeting is usually oversubscribed, submission of applications in early 2016 is strongly encouraged. A number of poster presenters from among the early applications will be invited to present short talks.

Contributors

Final Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Diversity of Chemistry in Nature
Discussion Leader: Michael Burkart (University of California, San Diego, USA)
7:40 pm - 8:05 pmMichael Fischbach (University of California, San Francisco, USA)
"Small Molecules from the Human Microbiota"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmAmy Wright (Florida Atlantic University, USA)
"Exploring Marine Biodiversity for Potential Therapeutics"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmCraig Townsend (Johns Hopkins University, USA)
"Carbapenems: Biosynthesis, Pathway Engineering and Lessons from Tuberculosis"
9:20 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmApplications of Bioorthogonal Chemistry
Discussion Leader: Kabirul Islam (University of Pittsburgh, USA)
9:00 am - 9:30 amJoseph Fox (University of Delaware, USA)
"Interfacial Bioorthogonal Chemistry: Discovery, Development, and Applications"
9:30 am - 9:40 amDiscussion
9:40 am - 10:10 amKate Carroll (The Scripps Research Institute, USA)
"Cysteine-Mediated Redox Signaling: Chemical Tools for Biological Discovery and Beyond"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:20 amThomas Sakmar (The Rockefeller University, USA)
"Bioorthogonal Labeling of Engineered Membrane Proteins to Enable Single Molecule Imaging"
11:20 am - 11:30 amDiscussion
11:30 am - 11:45 amSelected from Poster Abstracts: Jennifer Heemstra (University of Utah, USA)
"Nucleic Acids for Biosensing, Bioimaging, and Drug Delivery"
11:45 am - 11:50 amDiscussion
11:50 am - 12:05 pmSelected from Poster Abstracts: Zhen Huang (Pfizer Worldwide Research and Development, USA)
"Profiling Adduct Stability of Covalent Serine Hydrolase Inhibitors in Cells"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmSelected from Poster Abstracts: Yimon Aye (Cornell University / Weill Cornell Medicine, USA)
"Targeting Gain-of-Function Redox Events that Safeguard Metazoan Health and Survival"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Milka Kostic (Cell Chemical Biology, Cell Press, USA)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmIlluminating Biology with Imaging
Discussion Leader: Timothy Dore (New York University Abu Dhabi, United Arab Emirates)
7:30 pm - 8:00 pmAlice Ting (Massachusetts Institute of Technology, USA)
"Spatially-Resolved Proteomic Mapping of Living Cells"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmLuke Lavis (Janelia Research Campus, Howard Hughes Medical Institute, USA)
"Building Brighter Fluorophores for Cellular Imaging"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmMarcel Bruchez (Carnegie Mellon University, USA)
"The Fluorogen Switch: Rational Design of Fluorogenic Sensors and Optogenetic Tools"
9:20 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmBio-Inspired Synthesis
Discussion Leader: Daniel Appella (National Institute of Diabetes and Digestive and Kidney Diseases, NIH, USA)
9:00 am - 9:30 amJennifer Cochran (Stanford University, USA)
"Engineered Peptide-Drug Conjugates for Tumor Targeting Applications"
9:30 am - 9:40 amDiscussion
9:40 am - 10:10 amEric Schmidt (University of Utah, USA)
"The Posttranslational Modification Toolkit for Total Synthesis"
10:10 am - 10:20 amDiscussion
10:20 am - 10:40 amCoffee Break
10:40 am - 11:10 amHelma Wennemers (ETH Zurich, Switzerland)
"Bioinspired Chemistry with Proline-Rich Peptides"
11:10 am - 11:20 amDiscussion
11:20 am - 11:50 amMichael Jewett (Northwestern University, USA)
"Repurposing Ribosomes for Synthetic Biology"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmSelected from Poster Abstracts: Kristen DeMeester (University of Delaware, USA)
"Bioorthogonal Labeling on the Carbohydrate Backbone of E. coli Peptidoglycan"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Sarah Wallrodt (University of Konstanz, Germany)
"NAD+ Analogs for Cellular Imaging of Poly(ADP-ribos)ylation"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmGlycans in Health and Biology
Discussion Leader: Lara Mahal (New York University, USA)
7:30 pm - 8:00 pmDavid Vocadlo (Simon Fraser University, Canada)
"New Chemical Biology Tools for Studying Glycoconjugates In Vivo"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmPauline Rudd (National Institute for Bioprocessing Research and Training (NIBRT), Ireland)
"Glycoscience and the Systems Biology of Disease"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmJames Paulson (The Scripps Research Institute, USA)
"Modulating Immune Responses with Siglec Targeted Nanoparticles"
9:20 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmChemoproteomics in Therapeutic Applications
Discussion Leader: Brent Martin (University of Michigan, USA)
9:00 am - 9:30 amDaniel Nomura (University of California, Berkeley, USA)
"Mapping Metabolic Drivers of Disease Using Chemoproteomic and Metabolomic Platforms"
9:30 am - 9:40 amDiscussion
9:40 am - 10:10 amMarkus Schirle (Novartis Institutes for Biomedical Research, USA)
"Chemoproteomics-Based Approaches for Target Deconvolution of Bioactive Compounds"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:20 amStephan Sieber (Technical University of Munich, Germany)
"Chemical Tools to Manipulate Bacterial Pathogenesis"
11:20 am - 11:30 amDiscussion
11:30 am - 11:45 amSelected from Poster Abstracts: Michael Cohen (Oregon Health and Science University, USA)
"A Chemical Genetics Approach for Identifying Family-Member Specific Targets of ARTDs"
11:45 am - 11:50 amDiscussion
11:50 am - 12:05 pmSelected from Poster Abstracts: Keriann Backus (The Scripps Research Institute, USA)
"Proteome-Wide Covalent Ligand Discovery in Native Biological Systems"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmSelected from Poster Abstracts: Amit Choudhary (Broad Institute of MIT and Harvard / Harvard Medical School, USA)
"Multidimensional Chemogenic Control of CRISPR-Cas9 in Cells and Organisms"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmDrug Discovery and Therapeutics
Discussion Leader: David Rabuka (Catalent Pharma Solutions, USA)
7:30 pm - 8:00 pmAdam Johnson (Genentech, USA)
"Battling BTK Mutants"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmMarkus Bantscheff (Cellzome GmbH, Germany)
"Comprehensive Drug Target Profiling Using Orthogonal Chemoproteomics Technologies"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmDavid Gray (Pfizer, Inc, USA)
"Probing Molecular Features Which Contribute to Agonism and Signaling Bias at the Dopamine D1 Receptor"
9:20 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmApproaches to Tame Intractable Targets
Discussion Leader: Amanda Hargrove (Duke University, USA)
9:00 am - 9:30 amYueming Li (Memorial Sloan Kettering Cancer Center, USA)
"Regulation of Gamma-Secretase: From Small Molecules to Modulatory Subunits"
9:30 am - 9:40 amDiscussion
9:40 am - 10:10 amRobert Garbaccio (Merck and Co., Inc., USA)
"An Antibody-Drug Conjugate Approach to Tissue-Selective Glucocorticoids"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:20 amM.G. Finn (Georgia Institute of Technology, USA)
"Virus-Like Particle Based Delivery of Biological Function"
11:20 am - 11:30 amDiscussion
11:30 am - 11:45 amSelected from Poster Abstracts: Ryan Mehl (Oregon State University, USA)
"Ideal Bioorthogonal Ligations with Genetic Code Expansion"
11:45 am - 11:50 amDiscussion
11:50 am - 12:05 pmSelected from Poster Abstracts: John Schneekloth (National Cancer Institute, NIH, USA)
"Targeting Structurally and Functionally Diverse RNAs with Druglike Small Molecules"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmSelected from Poster Abstracts: Henning Stockmann (AbbVie Inc., USA)
"Glycan-Mediated Click Chemistry for Drug-Target Identification"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmAdvances in Chemical Biology
Discussion Leader: John Koh (University of Delaware, USA)
7:30 pm - 8:00 pmPaola Castaldi (AstraZeneca, USA)
"Small Molecules Driven Chemical Biology and Target Deconvolution Strategies"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmJohn Pezacki (University of Ottawa, Canada)
"Being SMART and Staying Active: Uncovering the Roles of RNAs and Enzymes in Host-Virus Interactions"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmGabriela Chiosis (Memorial Sloan Kettering Cancer Center, USA)
"Chemical Biology Approach to the Chaperome - From Mechanisms to Drugs and Diagnostics"
9:20 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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