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Meiosis
Gordon Research Conference

Molecular Mechanisms, Regulation and Integration of the Meiotic Program

Dates

June 26 - July 1, 2016

Location

Colby-Sawyer College
New London, NH

Organizers

Chair:
Neil Hunter

Vice Chair:
Monica P. Colaiacovo

Meeting Description

Meiosis is the specialized cell division that is central to sexual reproduction, and defines the essence of heredity, underpinning chromosome segregation, genetic linkage and genome evolution. Defects in meiosis are responsible for infertility, pregnancy miscarriage, and prominent birth defects such as Down Syndrome. At least one quarter of all pregnancies are miscarried, and 1-2% of babies are born with numerical or structural chromosome abnormalities traceable to errors in meiosis, making it the leading cause of congenital disease. Basic and clinical research on meiosis aims to understand and prevent pregnancy loss and chromosomal birth defects. The manipulation of meiosis also has important applications, especially for agro-biotechnology such as the breeding, engineering and improvement of sexually reproducing organisms including crops and animals. Recent advances include techniques to produce haploid plants and to accelerate the recombination of desirable traits. Such techniques promise to revolutionize plant breeding.

The Meiosis Gordon Research Conference (GRC) is the premier international forum for researchers studying basic, clinical and applied aspects of meiosis and will be held at Colby-Sawyer College in New London, NH on June 26 - July 1, 2016. A Gordon Research Seminar (GRS), Molecular Foundations of Sexual Reproduction, dedicated to the pedagogy of graduate students and postdoctoral fellows, will precede the main meeting from June 25-26. The 2016 Meiosis GRS will be held June 25-26 in the same location, immediately prior to the main GRC meeting. The GRS is a 1.5 day meeting, organized by graduate students and postdoctoral fellows, which offers a unique opportunity for junior researchers to network, present unpublished studies, and discuss topics that will be covered during the 4½-day Meiosis GRC. The ongoing intellectual goal of these conferences is to understand the fundamental mechanisms that underpin meiosis. The 2016 Meiosis GRC will emphasize emerging insights into the elaborate regulatory networks that control and integrate all aspects of meiotic prophase and thereby ensure the formation of balanced euploid gametes. The specific objectives of the meetings are to foster innovation, maximize participation across the career spectrum, create networks between young and established investigators, rapidly disseminate new and unpublished results, and promote interdisciplinary synergies.

Related Meeting

This GRC was held in conjunction with the "Meiosis" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmThe Synaptonemal Complex: Formation, Structure, and Function
Discussion Leader: Michael Lichten (National Cancer Institute, NIH, USA)
7:40 pm - 7:55 pmScott Hawley (Stowers Institute for Medical Research, USA)
"Multiple Players Control the Assembly and Disassembly of the Synaptonemal Complex in Drosophila"
7:55 pm - 8:00 pmDiscussion
8:00 pm - 8:15 pmAmy MacQueen (Wesleyan University, USA)
"On the Relationship Between Synaptonemal Complex and Interhomolog Recombination"
8:15 pm - 8:25 pmDiscussion
8:25 pm - 8:40 pmMonica Colaiacovo (Harvard Medical School, USA)
"Regulation of the Synaptonemal Complex in C. elegans"
8:40 pm - 8:45 pmDiscussion
8:45 pm - 9:00 pmKim McKim (Rutgers University, USA)
"Dynamic and Stable Cohesins Regulate Synaptonemal Complex Assembly and Chromosome Segregation"
9:00 pm - 9:05 pmDiscussion
9:05 pm - 9:20 pmAbby Dernburg (University of California, Berkeley, USA)
"A Signaling Circuit that Designates and Constrains Crossovers Operates Autonomously Within the Synaptonemal Complex"
9:20 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmHomologous Recombination: Mechanisms, Integration and Regulation
Discussion Leader: Eva Hoffmann (University of Copenhagen, Denmark)
9:00 am - 9:15 amDouglas Bishop (The University of Chicago, USA)
"Biochemical Reconstitution of Meiotic Recombination"
9:15 am - 9:25 amDiscussion
9:25 am - 9:40 amJeremy Wang (University of Pennsylvania, USA)
"Regulation of Meiotic Recombination by ssDNA-Binding Proteins"
9:40 am - 9:50 amDiscussion
9:50 am - 10:05 amJeff Sekelsky (University of North Carolina at Chapel Hill, USA)
"What Happens When All of Your Crossovers Are 2nd Class?"
10:05 am - 10:15 amDiscussion
10:15 am - 10:45 amCoffee Break
10:45 am - 11:00 amFrancesca Cole (University of Texas MD Anderson Cancer Center, USA)
"Active Suppression of Mitotic Recombination Pathways Promotes Crossover Assurance in the Mouse"
11:00 am - 11:15 amDiscussion
11:15 am - 11:30 amRaphael Mercier (Institut National de la Recherche Agronomique, France)
"Unleashing Meiotic Crossovers (or Turning Arabidopsis into Fission Yeast)"
11:30 am - 11:40 amDiscussion
11:40 am - 11:55 amMichael Lichten (National Cancer Institute, NIH, USA)
"Regulation of Recombination Intermediate Metabolism During Meiosis"
11:55 am - 12:05 pmDiscussion
12:05 pm - 12:20 pmNancy Hollingsworth (Stony Brook University, USA)
"Synaptonemal Complex Disassembly Activates Rad51-Mediated Recombination During Budding Yeast Meiosis"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Amy MacQueen (Wesleyan University, USA) and Julie Cooper (National Cancer Institute, NIH, USA)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMeiotic Errors: Mechanisms and Clinical Implications
Discussion Leader: Matthew Neale (University of Sussex, United Kingdom)
7:30 pm - 7:45 pmIan Adams (MRC Human Genetics Unit, United Kingdom)
"Maintaining Sister Chromatid Cohesion and Preventing Aneuploidy in Post-Natal Mouse Oocytes"
7:45 pm - 7:50 pmDiscussion
7:50 pm - 8:05 pmSharon Bickel (Dartmouth College, USA)
"Damaged Goods: Evidence that Oxidative Stress in Oocytes During Meiotic Prophase Induces Premature Loss of Cohesion and Chromosome Segregation Errors"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:30 pmNancy Kleckner (Harvard University, USA)
"Elevated Human Female Aneuploidy Results from a Programmed Defect in Crossover Recombination"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 8:55 pmCaroline Sartain (Washington State University, USA)
"Effects of Environmental Estrogens on Mammalian Meiosis"
8:55 pm - 9:05 pmDiscussion
9:05 pm - 9:20 pmEva Hoffmann (University of Copenhagen, Denmark)
"Chromosome Deterioration and Human Aneuploidy"
9:20 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmChromosome Segregation: Kinetochores, Cohesion, Chiasmata and Spindles
Discussion Leader: Gloria Brar (University of California, Berkeley, USA)
9:00 am - 9:15 amTomoya Kitajima (RIKEN Center for Developmental Biology, Japan)
"Effects of Oocyte Size on Chromosome Segregation During Meiosis"
9:15 am - 9:25 amDiscussion
9:25 am - 9:40 amFrancis McNally (University of California, Davis, USA)
"A Novel Chromosome Segregation Mechanism During Female Meiosis"
9:40 am - 9:50 amDiscussion
9:50 am - 10:05 amAdele Marston (University of Edinburgh, United Kingdom)
"Regulation of the Meiosis I to Meiosis II Transition"
10:05 am - 10:15 amDiscussion
10:15 am - 10:45 amGroup Photo / Coffee Break
10:45 am - 11:00 amYoshinori Watanabe (University of Tokyo, Japan)
"Mechanisms of Chromosome Mono-Orientation in Meiosis I"
11:00 am - 11:10 amDiscussion
11:10 am - 11:25 amAkira Shinohara (Institute for Protein Research, Osaka University, Japan)
"Prophase Pathway for Removal of a Meiosis-Specific Cohesin from Arms of Chromosomes During Late Prophase I of Meiosis"
11:25 am - 11:40 amDiscussion
11:40 am - 11:55 amPaula Cohen (Cornell University, USA)
"Nima-Like Kinase 1 (NEK1) Orchestrates a Prophase I Pathway for Cohesin Removal in Mammalian Meiosis"
11:55 am - 12:05 pmDiscussion
12:05 pm - 12:20 pmEnrique Martinez-Perez (Imperial College London, United Kingdom)
"Temporospatial Regulation of Aurora B Recruitment Controls the Two-Step Release of Sister Chromatid Cohesion"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmEpigenetics, Germ Cells and Gametes
Discussion Leader: Joanne Engebrecht (University of California, Davis, USA)
7:30 pm - 7:45 pmKatja Wassmann (Institut de Biologie Paris-Seine (IBPS), Université Pierre-et-Marie-Curie, France)
"How Oocytes Try to Get It Right: Mechanisms of Chromosome Segregation in Meiosis"
7:45 pm - 7:55 pmDiscussion
7:55 pm - 8:10 pmSatoshi Namekawa (Cincinnati Children's Hospital Medical Center, USA)
"Programmed Gene Silencing During Meiosis: Mechanism and Function"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:35 pmGloria Brar (University of California, Berkeley, USA)
"Non-Canonical Translation in Meiosis"
8:35 pm - 8:45 pmDiscussion
8:45 pm - 9:00 pmMina Kojima (Whitehead Institute for Biomedical Research, USA)
"Regulation of Gene Expression at Mammalian Meiotic Initiation"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmAlex Bortvin (Carnegie Institution for Science, USA)
"Transient Relaxation of DNA Methylation at the Onset of Male Meiosis in Mice"
9:25 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCheckpoints and Regulation of Meiotic Progression
Discussion Leader: Adele Marston (University of Edinburgh, United Kingdom)
9:00 am - 9:15 amSadie Sarah Wignall (Northwestern University, USA)
"Regulation of Chromosome Segregation in C. elegans Oocytes"
9:15 am - 9:25 amDiscussion
9:25 am - 9:40 amAttila Toth (Technische Universität Dresden, Germany)
"HORMAD Proteins at the Interface of Chromosome Structure, Checkpoints and Recombination"
9:40 am - 9:50 amDiscussion
9:50 am - 10:05 amKevin Corbett (University of California, San Diego / Ludwig Institute for Cancer Research, USA)
"Assembly and Dynamics of the Yeast Meiotic Chromosome Axis"
10:05 am - 10:15 amDiscussion
10:15 am - 10:45 amCoffee Break
10:45 am - 11:00 amMatthew Neale (University of Sussex, United Kingdom)
"Spatial Patterning of Meiotic Recombination"
11:00 am - 11:10 amDiscussion
11:10 am - 11:25 amFranz K. Klein (Max F. Perutz Laboratories, University of Vienna, Austria)
"Spo11 Releases Double Stranded DNA-Fragments from Meiotic Chromosomes in Mutant and Wild-Type Yeast"
11:25 am - 11:35 amDiscussion
11:35 am - 11:50 amHong Ma (Fudan University, China)
"The Arabidopsis CDC20.1 Gene Is Required for Normal Meiotic Spindle Assembly and Chromosome Segregation"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:15 pmRachel Wang (Academia Sinica, Taiwan)
"The Mitosis-to-Meiosis Transition of Male Germline Is Controlled by Mac1 and Am1 in Maize"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmHomologous Recombination: When, Where and How Many
Discussion Leader: Roberto Pezza (Oklahoma Medical Research Foundation, USA)
7:30 pm - 7:45 pmBernard De Massy (Institute of Human Genetics, France)
"A TopoVI-Like Complex Is Required for Meiotic DNA Double Strand Break Formation"
7:45 pm - 7:55 pmDiscussion
7:55 pm - 8:10 pmScott Keeney (Memorial Sloan Kettering Cancer Center, USA)
"Breaking and Chewing DNA"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:35 pmGregory Copenhaver (University of North Carolina, USA)
"Modulators of Meiotic Recombination in Arabidopsis"
8:35 pm - 8:45 pmDiscussion
8:45 pm - 9:00 pmMonique Zetka (McGill University, Canada)
"A Family of SUMO E3 Ligase-Like Proteins Are Required for Crossover Formation in C. elegans"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmAnne Villeneuve (Stanford University, USA)
"Interplay Between Recombination and Chromosome Structure During C. elegans Meiosis"
9:25 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmMeiotic Chromosome Morphogenesis: Chromatin Organization, Chromosome Movement and Homolog Pairing
Discussion Leader: Kevin Corbett (University of California, San Diego / Ludwig Institute for Cancer Research, USA)
9:00 am - 9:15 amKikue Tachibana-Konwalski (IMBA - Institute of Molecular Biotechnology, Austria)
"Novel Single-Cell Hi-C Reveals Unique Chromatin Reorganisation During the Mammalian Oocyte-to-Zygote Transition"
9:15 am - 9:25 amDiscussion
9:25 am - 9:40 amVerena Jantsch (University of Vienna / Max F. Perutz Laboratories, Austria)
"Reorganization of the Nuclear Lamina During Meiotic Chromosome Movement in Caenorhabditis elegans"
9:40 am - 9:50 amDiscussion
9:50 am - 10:05 amJulie Cooper (National Cancer Institute, NIH, USA)
"Interplay Between Telomeres and Centromeres During Meiosis"
10:05 am - 10:15 amDiscussion
10:15 am - 10:45 amCoffee Break
10:45 am - 11:00 amDenise Zickler (Institut de Genetique et Microbiologie, Université Paris-Sud, France)
"From Synaptonemal Complex to Spindle Pole Body"
11:00 am - 11:10 amDiscussion
11:10 am - 11:25 amViji Subramanian (New York University, USA)
"Control of DNA Breakage and Repair in Meiosis"
11:25 am - 11:35 amDiscussion
11:35 am - 11:50 amRoberto Pezza (Oklahoma Medical Research Foundation, USA)
"Control of Meiotic Double-Strand Break Repair by Chromatin Remodeling Complexes"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:15 pmGerald Smith (Fred Hutchinson Cancer Research Center, USA)
"How Harmful Meiotic Recombination Around Centromeres Is Repressed"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmEvolution of Meiosis: Conservation and Diversity of Programs, Structures and Mechanisms
Discussion Leader: Kim McKim (Rutgers University, USA)
7:30 pm - 7:45 pmJoanne Engebrecht (University of California, Davis, USA)
"Not All Germ Cells Are Created Equally: Sex-Specific Regulation of Meiotic Recombination"
7:45 pm - 7:55 pmDiscussion
7:55 pm - 8:10 pmR. Daniel Camerini-Otero (National Institute of Diabetes and Digestive and Kidney Diseases, NIH, USA)
"Beyond DNA Sequence: The Importance of Context on Meiotic DSB Hotspot Location and Strength"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:35 pmPeter van Dijk (KeyGene, The Netherlands)
"Cloning the Apomeiosis Gene from Apomictic Dandelion (Taraxacum officinale)"
8:35 pm - 8:45 pmDiscussion
8:45 pm - 9:00 pmSarah Zanders (Stowers Institute for Medical Research, USA)
"Meiotic Drive via a Gamete-Killing Poison and Antidote Encoded by a wtf Gene"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmSean Burgess (University of California, Davis, USA)
"Positional Cues Within the Nucleus Underlie the Dynamic Chromosome Events of Meiosis in Zebrafish"
9:25 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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