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Malaria
Gordon Research Conference

Translating Malaria Research to the Field

Dates

July 26-31, 2015

Location

PGA Catalunya Business and Convention Centre
Girona, Spain

Organizers

Chair:
Robert Sauerwein

Vice Chair:
Maria Mota

Meeting Description

Development of novel strategies to combat malaria requires a clear understanding of the parasite in its human and mosquito hosts, in order to develop and implement new control and eradication tools. The 2015 Gordon Research Conference (GRC) on Malaria will focus on disease including severe malaria and pregnancy-associated malaria, transmission, epidemiology and control with possible application in the field. The conference will provide a forum to discuss cutting edge basic and applied research on malaria, with an emphasis on the development of novel tools and implementation of measures intended to treat, control, and eradicate malaria. This will be accomplished by inviting global leaders working in different areas of malaria research, or in fields outside the traditional malaria research areas that can stimulate new thinking and approaches to the malaria problem.

The conference will be preceded by the Malaria Gordon Research Seminar from July 25th-26th, 2015 targeted at graduate students, post-docs and junior scientists.

Related Meeting

This GRC was held in conjunction with the "Malaria" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmDrug Development and Resistance
Discussion Leader: Sirima Sodiomon Bienvenu (The National Center for Research and Training on Malaria, Burkina Faso)
7:40 pm - 7:50 pmIntroduction by Discussion Leader
7:50 pm - 8:05 pmArjen Dondorp (Mahidol University, Thailand)
"Artemisinin Resistance"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:30 pmThierry Diagana (Novartis Institute for Tropical Diseases, Singapore)
"Advances in Antimalarial Drug Discovery and Development"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 8:55 pmAbdoulaye Djimde (University of Science and Technologies, Mali)
"P. falciparum Resistance to Artemisinins: Any Worries for Sub-Saharan Africa?"
8:55 pm - 9:05 pmDiscussion
9:05 pm - 9:20 pmDidier Leroy (Medicines for Malaria Venture, Switzerland)
"Surmounting Drug Resistance with Next-Generation Antimalarials: Medicines for Malaria Venture's R&D Portfolio"
9:20 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm(Molecular) Biology of Asexual and Sexual Stage Parasites
Discussion Leader: Andy Waters (Wellcome Trust Centre for Molecular Parasitology, United Kingdom)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:30 amAlexandra Rowe (University of Edinburgh, United Kingdom)
"PfEMP1 Interactions with Erythrocyte and Endothelial Cell Receptors in Severe Malaria"
9:30 am - 9:40 amDiscussion
9:40 am - 10:00 amMatthias Marti (Harvard T.H. Chan School of Public Health, USA)
"Mechanisms of Gametocyte Formation and Tissue Sequestration in Plasmodium falciparum"
10:00 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 11:00 amTania De Koning-Ward (Deakin University, Australia)
"Host Cell Remodelling by Malaria Parasites"
11:00 am - 11:10 amDiscussion
11:10 am - 11:30 amPietro Alano (Institute of Public Health, Italy)
"Plasmodium Falciparum Gametocyte Development and Interplay with the Human Host"
11:30 am - 11:40 amDiscussion
11:40 am - 12:00 pmJulian Rayner (Wellcome Trust Sanger Institute, United Kingdom)
"Genome Scale Experimental Genetic Screening of Plasmodium Parasites"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmImmunology in the Lab and in the Field
Discussion Leader: James Beeson (Burnet Institute, Australia)
6:00 pm - 6:20 pmIntroduction by Discussion Leader
6:20 pm - 6:35 pmPeter Crompton (National Institute of Allergy and Infectious Disease, NIH, USA)
"T Follicular Helper Cell Response to Malaria: Potential Implications for Vaccine Design"
6:35 pm - 6:45 pmDiscussion
6:45 pm - 7:00 pmJames Beeson (Burnet Institute, Australia)
"Defining Key Mechanisms of Human Immunity to Malaria to Advance Vaccine Development"
7:00 pm - 7:10 pmDiscussion
7:10 pm - 7:25 pmYunshan Goh (Singapore Immunology Network, Singapore)
"Breadth of the Humoral Response and Potential Vaccine Targets Following Experimental Plasmodium falciparum Sporozoite Inoculation in Humans"
7:25 pm - 7:35 pmDiscussion
7:35 pm - 7:50 pmDouglas Golenbock (University of Massachusetts Medical School, USA)
"Innate Immune Responses Against Plasmodium"
7:50 pm - 8:00 pmDiscussion
8:00 pmDinner
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmModels in Animals and Humans
Discussion Leader: Stefan Kappe (Seattle Biomedical Research Institute, USA)
9:00 am - 9:15 amIntroduction by Discussion Leader
9:15 am - 9:35 amStefan Kappe (Seattle Biomedical Research Institute, USA)
"Bridging Animal Models and Human Malaria Research with Humanized Mice"
9:35 am - 9:45 amDiscussion
9:45 am - 10:05 amClemens Kocken (Biomedical Primate Research Centre, The Netherlands)
"Non-Human Primate Models for P. vivax Malaria"
10:05 am - 10:15 amDiscussion
10:15 am - 10:45 amCoffee Break
10:45 am - 11:05 amElse Bijker (Radboud University Nijmegen Medical Centre, The Netherlands)
"Chemoprophylaxis and Sporozoites Immunization: A Valuable Model to Study Protective Immunity in Humans"
11:05 am - 11:15 amDiscussion
11:15 am - 11:30 amPhilip Spence (University of Edinburgh, United Kingdom)
"Using Mosquitoes to Unlock Immunity to Malaria"
11:30 am - 11:40 amDiscussion
11:40 am - 11:55 amSangeeta Bhatia (Massachusetts Institute of Technology, USA)
"Engineered Hepatic Tissues for Modeling Liver Stage Malaria"
11:55 am - 12:05 pmDiscussion
12:05 pm - 12:20 pmJames McCarthy (QIMR Berghofer Medical Research Institute, Australia)
"Life Cycle Specific Transcripts in Plasmodium falciparum Malaria"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmPregnancy Associated Malaria
Discussion Leader: Patrick Duffy (National Institute of Allergy and Infectious Disease, NIH, USA)
6:00 pm - 6:10 pmIntroduction by Discussion Leader
6:10 pm - 6:30 pmFeiko Ter Kuile (Liverpool School of Tropical Medicine, United Kingdom)
"SP Resistance and Alternative Strategies for the Control of Malaria in Pregnancy"
6:30 pm - 6:40 pmDiscussion
6:40 pm - 7:00 pmAlfredo Mayor (Barcelona Centre for International Health Research, Spain)
"Targeting Pregnant Women to Asses Malaria Transmission"
7:00 pm - 7:10 pmDiscussion
7:10 pm - 7:30 pmPhilippe Boeuf (Burnet Institute, Australia)
"Mechanisms of Fetal Growth Restriction in Placental Malaria"
7:30 pm - 7:40 pmDiscussion
7:40 pm - 7:55 pmDanny Milner (Brigham and Women's Hospital, USA)
"Pediatric Cerebral Malaria Pathology from Autopsy to Genetics"
7:55 pm - 8:00 pmDiscussion
8:00 pmDinner
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmVaccines Tested in Controlled Human Malaria Infections and in the Field
Discussion Leader: Salim Abdulla (Ifakara Health Institute, Tanzania)
9:00 am - 9:15 amIntroduction by Discussion Leader
9:15 am - 9:35 amJohan Vekemans (GlaxoSmithKline Vaccines, Belgium)
"Building on RTS,S: Towards an Improved Second Generation Malaria Vaccine"
9:35 am - 9:50 amDiscussion
9:50 am - 10:10 amStephen Hoffman (Sanaria Inc., USA)
"A Highly Effective PfSPZ Vaccine in Our Time: Progress, Challenges, and Timeline for Licensure"
10:10 am - 10:25 amDiscussion
10:25 am - 10:55 amCoffee Break
10:55 am - 11:15 amAdrian Hill (Jenner Institute, University of Oxford, United Kingdom)
"Towards Multi-Component Subunit Vaccines for Malaria"
11:15 am - 11:30 amDiscussion
11:30 am - 11:50 amSimon Draper (Jenner Institute, University of Oxford, United Kingdom)
"The Latest Developments of Vaccines Against the Blood-Stage Parasite"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmMiguel Prudencio (Instituto de Medicina Molecular, Portugal)
"Towards Clinical Evaluation of a Rodent Plasmodium-Based Vaccine Against Human Malaria"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmSevere Malaria and Pathophysiology 
Discussion Leader: Nick Anstey (Menzies School of Health Research, Australia)
6:00 pm - 6:10 pmIntroduction by Discussion Leader
6:10 pm - 6:30 pmAndre Siqueira (National Institute of Infectious Diseases, Brazil)
"The Clinical Burden of Vivax Malaria"
6:30 pm - 6:40 pmDiscussion
6:40 pm - 7:00 pmMats Wahlgren (Karolinska Institutet, Sweden)
"Roles of RIFINs and PfEMP1 in P. Falciparum Sequestration"
7:00 pm - 7:10 pmDiscussion
7:10 pm - 7:30 pmMaria Mota (Instituto de Medicina Molecular, Portugal)
"Nutrient Sensing Modulates Plasmodium Virulence"
7:30 pm - 7:40 pmDiscussion
7:40 pm - 8:00 pmPoster Previews
8:00 pmDinner
Thursday
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmTransmission Stages in Humans and Mosquitoes
Discussion Leader: Chris Drakeley (London School of Hygiene and Tropical Medicine, United Kingdom)
9:00 am - 9:15 amIntroduction by Discussion Leader
9:15 am - 9:35 amElena Levashina (Max Planck Institute for Infection Biology, Germany)
"Mosquito Factors that Restrict Plasmodium Development in the Mammalian Host"
9:35 am - 9:45 amDiscussion
9:45 am - 10:05 amTeun Bousema (Radboud University Nijmegen Medical Centre, The Netherlands)
"Defining the Human Infectious Reservoir for Malaria"
10:05 am - 10:15 amDiscussion
10:15 am - 10:35 amAzra Ghani (Imperial College London, United Kingdom)
"The Implications of the P.falciparum Infectious Reservoir for Malaria Elimination Strategies"
10:35 am - 10:45 amDiscussion
10:45 am - 11:15 amCoffee Break
11:15 am - 11:30 amFlaminia Catteruccia (Harvard T.H. Chan School of Public Health, USA)
"Reproduction and Plasmodium Transmission by the Anopheles Vector"
11:30 am - 11:40 amDiscussion
11:40 am - 11:55 amIngrid Felger (Swiss Tropical and Public Health Institute, Switzerland)
"Transmission Dynamics of P. falciparum and P. vivax - Molecular Approaches"
11:55 am - 12:05 pmDiscussion
12:05 pm - 12:20 pmAlassane Dicko (University of Bamako, Mali)
"Dose Escalation Study of Safety and Efficacy of Low Single-Dose Primaquine for Gametocytocidal Activity Against P. falciparum in Mali"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmBiology of Sporozoites and Liverstages
Discussion Leader: Maria Mota (Instituto de Medicina Molecular, Portugal)
6:00 pm - 6:10 pmIntroduction by Discussion Leader
6:10 pm - 6:30 pmJohn Harty (University of Iowa, USA)
"CD8 T Cell Immunity to Plasmodium Liver Stage Infection"
6:30 pm - 6:40 pmDiscussion
6:40 pm - 7:00 pmValerie Soulard (Centre d Immunologie et des Maladies Infectieuses, France)
"Investigation of CD8 T-Cell Responses Against Plasmodium In Vitro and In Vivo"
7:00 pm - 7:05 pmDiscussion
7:05 pm - 7:25 pmJustin Boddey (The Walter and Eliza Hall Institute, Australia)
"An Inhibitor of Erythrocyte Invasion Blocks P. falciparum Invasion and Traversal of Hepatocytes"
7:25 pm - 7:30 pmDiscussion
7:30 pm - 7:40 pmMarvin Duvalsaint (University of South Florida, USA)
"Phytohormones and the Role of the Apicoplast in Dormancy in the Erythrocytic Stages of Plasmodium falciparum"
7:40 pm - 7:45 pmDiscussion
7:45 pm - 7:55 pmZenon Zenonos (Wellcome Trust Sanger Institute, United Kingdom)
"Basigin Is a Druggable Target for Host Oriented Anti-Malarial Interventions"
7:55 pm - 8:00 pmDiscussion
8:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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