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Cellulosomes, Cellulases and Other Carbohydrate Modifying Enzymes
Gordon Research Conference

A New Era of Research on Carbohydrate-Active Enzymes: Their Reaction Mechanisms and Evolution
Note: This conference is currently known as "Cellulases and Other Carbohydrate-Active Enzymes".

Dates

August 2-7, 2015

Location

Proctor Academy
Andover, NH

Organizers

Chair:
Kiyohiko Igarashi

Vice Chair:
Bernard P. Henrissat

Meeting Description

The 2015 Gordon Conference on Cellulosomes, Cellulases, and Other Carbohydrate Modifying Enzymes will present cutting-edge research on the enzymatic degradation of cellulose and other plant cell wall components. The Conference will feature a range of current topics that includes the enzymology related to biosynthesis and biodegradation of plant polysaccharides, metagenomic approaches for cell wall-degrading organisms, structure-function relationships in Carbohydrate-Active enzymes, as well as advances in applications of these enzymes in the biofuel/biorefinery contexts. The 2015 Conference will also include evolutionary aspects of biomass degrading enzymes, an area boosted by the recent availability of a vast number of genomes. Contributions on enzymes related to polysaccharide modification, not only hydrolases but also synthases, esterases, lyases, oxidoreductases and non-catalytic carbohydrate-interacting proteins, will be particularly welcome. Invited speakers represent a variety of scientific disciplines, including plant cell wall structure, enzymology, structural biology, genetics and cell biology. The interplay between fundamental research and its industrial exploitation is a particularly important aspect of the meeting.

The collegial atmosphere of this Conference, which includes ample time for formal discussion sessions and informal gatherings in the afternoons and evenings, provides an excellent environment for scientists from different disciplines - and both from academic and industrial backgrounds - to interact, thereby promoting cross-disciplinary collaborations. Moreover, the meeting and the associated GRS will provide opportunities for junior scientists and graduate students to present their work and exchange ideas with more established figures in the field. To incorporate the most recent advances and to provide speaking opportunities to young researchers, a number of oral presentations at this GRC will be selected from the submitted abstracts. The Conference is likely to be heavily subscribed, so it is strongly suggested that applications to attend be submitted as soon as possible. Priority will generally be given to attendees who demonstrate active participation in the meeting through the submission of a presentation abstract.

Related Meeting

This GRC was held in conjunction with the "Cellulosomes, Cellulases and Other Carbohydrate Modifying Enzymes" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Evolution and Reaction Mechanisms of Carbohydrate-Active Enzymes
Discussion Leader: Edward Bayer (Weizmann Institute of Science, Israel)
7:40 pm - 8:20 pmDavid Hibbett (Clark University, USA)
"Phylogenomics and CAZYme Evolution in Agaricomycetes"
8:20 pm - 8:35 pmDiscussion
8:35 pm - 9:15 pmJerry Stahlberg (Swedish University of Agricultural Sciences, Sweden)
"What Have We Learned About Structure and Function of Fungal Cellulase Enzymes?"
9:15 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmEvolution of Carbohydrate-Active Enzymes and Their Substrates
Discussion Leader: Harry Brumer (University of British Columbia, Canada)
9:00 am - 9:35 amMark Morrison (The University of Queensland Diamantina Institute, Australia)
"Do You Hold Them Close, Let Them Free, or Something in Between? A Closer Look at the Fibrobacteres"
9:35 am - 9:50 amDiscussion
9:50 am - 10:25 amMary Berbee (University of British Columbia, Canada)
"Phylogenomic Analysis of Pectinase Enzymes Points to Early Fungi Evolution in Association with the Land Plant Lineage"
10:25 am - 10:40 amDiscussion
10:40 am - 11:10 amCoffee Break
11:10 am - 11:45 amSteven Ball (University of Lille, France)
"With a Little Help from Friends: Understanding Metabolic Integration of Photosynthetic Organelles"
11:45 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmBirte Svensson (Technical University of Denmark, Denmark)
"Surface Binding Sites in Carbohydrate-Active Enzymes"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmSynthesis and Modification of Carbohydrates in Plant Cell Walls
Discussion Leader: Harry Gilbert (University of Newcastle, United Kingdom)
7:30 pm - 8:05 pmToshihisa Kotake (Saitama University, Japan)
"Stepwise Trimming of Carbohydrate Moieties of AGP Using Glycoside Hydrolases"
8:05 pm - 8:20 pmDiscussion
8:20 pm - 8:55 pmDebra Mohnen (University of Georgia, USA)
"New Models for Plant Cell Wall Structure from Studies of Pectin Biosynthetic Glycosyltransferases and Their Mutant Phenotypes"
8:55 pm - 9:10 pmDiscussion
9:10 pm - 9:30 pmGeneral Discussion
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmRedox Enzyme(s) Boosting Polysaccharide Degradation
Discussion Leader: Leila Lo Leggio (University of Copenhagen, Denmark)
9:00 am - 9:30 amBjorge Westereng (Norwegian University of Life Sciences, Norway)
"Lytic Polysaccharide Monooxygenases: Nature's Oxidative Tools for Biomass Processing"
9:30 am - 9:40 amDiscussion
9:40 am - 10:15 amRoland Ludwig (Universitat für Bodenkultur, Austria)
"Structural Evidence for Domain Movement in Cellobiose Dehydrogenase and Its Role in Interprotein Electron Transfer to Lytic Polysaccharide Monooxygenase"
10:15 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:35 amPaul Walton (University of York, United Kingdom)
"Recent Insights into the Reactivity and Structure of Lytic Polysaccharide Monooxygenases"
11:35 am - 11:50 amDiscussion
11:50 am - 12:20 pmJean-Guy Berrin (French National Institute for Agricultural Research, France)
"Identification, Substrate Specificity and Regioselectivity of Fungal AA9 LPMOs"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmVisualization of Cellulase Action
Discussion Leader: Satoshi Kaneko (University of the Ryukyus, Japan)
7:30 pm - 8:05 pmDouglas Clark (University of California, Berkeley, USA)
"Kinetic and Modeling Studies of Cellulase-Substrate Interactions: From Single Molecules to Cocktail Mixtures"
8:05 pm - 8:20 pmDiscussion
8:20 pm - 8:55 pmShigeru Deguchi (Japan Agency for Marine-Earth Science and Technology, Japan)
"Ultra-Sensitive Assay of Cellulose Hydrolysis by Using Nanofibrous Substrates Combined with 3D Profilometry"
8:55 pm - 9:10 pmDiscussion
9:10 pm - 9:30 pmGeneral Discussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmHydrolytic Mechanisms of Glycosidic Bonds
Discussion Leader: Stephen Withers (University of British Columbia, Canada)
9:00 am - 9:35 amPeter Westh (Roskilde University, Denmark)
"Kinetic Modeling of Cellobiohydrolases: In Search of Rate Limiting Steps"
9:35 am - 9:50 amDiscussion
9:50 am - 10:25 amGregg Beckham (National Renewable Energy Laboratory, USA)
"Structure-Function Relationships in Fungal Cellulases"
10:25 am - 10:40 amDiscussion
10:40 am - 11:10 amCoffee Break
11:10 am - 11:45 amShino Manabe (Riken, Japan)
"Reinvestigation of Glycosyl Bond Cleavage"
11:45 am - 12:00 pmDiscussion
12:00 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmRegulation of Enzyme Production for Biofuel and Biorefinery
Discussion Leader: Merja Penttila (VTT Technical Research Centre of Finland, Finland)
7:30 pm - 8:05 pmLouise Glass (University of California, Berkeley, USA)
"Mapping the Transcriptional Network Associated with Fungal Deconstruction of Plant Biomass"
8:05 pm - 8:20 pmDiscussion
8:20 pm - 8:55 pmAndrew Tolonen (Genoscope-CEA / University of Evry, France)
"Exploring and Expanding CAZyme Diversity in Clostridium phytofermentans"
8:55 pm - 9:10 pmDiscussion
9:10 pm - 9:30 pmGeneral Discussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmProtein-Protein and/or Protein-Carbohydrate Interaction in Carbohydrate-Active Enzymes
Discussion Leader: Alisdair Boraston (University of Victoria, Canada)
9:00 am - 9:35 amChristina Payne (University of Kentucky, USA)
"The Role of Glycosylated Linkers in Multimodular Cellulase Function"
9:35 am - 9:50 amDiscussion
9:50 am - 10:25 amHenri-Pierre Fierobe (Institute of Structural Biology and Microbiology, CNRS, France)
"Wild-Type and Engineered GH9 Collection in the Cellulosome-Producing Bacterium Clostridium cellulolyticum"
10:25 am - 10:40 amDiscussion
10:40 am - 11:10 amCoffee Break
11:10 am - 11:45 amMichelle O'Malley (University of California, Santa Barbara, USA)
"New Enzymes from Old Microbes: Exploiting Anaerobic Fungi for Biomass Breakdown"
11:45 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmLior Artzi (Weizmann Institute of Science, Israel)
"Key Cellulosome Players Are Revealed by Cellulosomic and Proteomic Analyses"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmUtilization of Cellulolytic Enzymes for Future Renewable Society
Discussion Leader: Mike Himmel (National Renewable Energy Laboratory, USA)
7:30 pm - 8:05 pmKen Tokuyasu (National Food Research Institute, National Agriculture and Food Research Organization, Japan)
"Cellulases for Calcium-Capturing-by-Carbonation (CaCCO) Process, a Simple Sugar Platform for Herbaceous Lignocellulosics in Japan"
8:05 pm - 8:20 pmDiscussion
8:20 pm - 8:55 pmKristiina Kruus (VTT Technical Research Centre of Finland, Finland)
"Non-Productive Enzyme Adsorption in the Enzymatic Hydrolysis of Lignocellulose"
8:55 pm - 9:10 pmDiscussion
9:10 pm - 9:15 pmGeneral Discussion
9:15 pm - 9:30 pmClosing Remarks
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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