Understanding the Varied Pathological Roles of a Multifunctional Enzyme Family

Transglutaminases are a large family of structurally and functionally related proteins widely distributed in all living organisms. The predominant and classical function of these enzymes is as protein cross linkers, however as more is discovered about their biology additional roles ranging from non-enzymatic cell adhesion to GTPase activity complicate our understanding of their function in human biology.

There is a rapidly expanding literature describing dysregulation of these enzymes in multiple diseases and how this contributes to the pathogenesis of human diseases. Tissue fibrosis, cancer and metastasis, celiac disease, neurodegenerative disorders such as Parkinson's disease, and skin diseases are just a few examples of where Transglutaminases have been implicated. The 4th Gordon Research Conference on "Transglutaminases in Human Disease Processes" will delve into many disease areas to try and establish where Transglutaminases are central to the disease process so we can better understand the interaction of function with the pathogenic roles being ascribed. Further the conference will address ways to restore normal enzyme function and explore the tools available to help us monitor enzyme levels and function as some approaches approach the clinic.

The meeting will discuss the latest cutting-edge research in the Transglutaminase biology, bringing together the most eminent researchers in Transglutaminase biology from across the world with disease experts. This conference aims to blend the expertise of seasoned scientists with young enthusiastic new comers to the field.

Each session will be aimed at a particular disease area with the discussion lead tasked with building a focused and themed program to maximize participation and output. The sessions will include:

• Modulators, Structures and Substrates of Transglutaminases
• The Function of Transglutaminases in Cardiovascular Disease
• Transglutaminases in Tissue Remodelling, Fibrosis and Scarring
• Do Transglutaminases Play a Role in Immunology and Rheumatology disorders?
• What Role do Transglutaminases Play in Neurological disease?
• Celiac Disease, Gastroenterology and Transglutaminases
• Transglutaminases in Oncology
• The Contribution of Transglutaminases to Connective Tissue Disorders

Each presentation within the session will have ample time for in depth discussion. There will also be 4 poster sessions providing a great opportunity for Post-Docs and graduate students to present their work under an informal relaxed atmosphere that fosters networking and idea sharing. For the first time there will be an additional session for the best abstracts from young investigators to be presented as short talks.

The 2016 Gordon Research Conference will bring together the world's leading researchers in the Transglutaminase field at PGA Catalunya Business and Convention Centre in Girona, Spain. This is a fantastic site located within the Catalunya golf course which is regarded as one of the best and most beautiful in Spain. Situated within easy reach of the beautiful beaches of the Costa Brava this is just 5km from Girona airport. The convention centre provides an excellent setting for formal lectures and informal out-of-session discussions, with excellent accommodation, dinning and recreational options.