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Glycobiology (GRS)
Gordon Research Seminar

Glycans as Mediators of Interactions Between Molecules, Cells and Organisms

Dates

February 28 - March 1, 2015

Location

Renaissance Tuscany Il Ciocco
Lucca (Barga), Italy

Organizers

Chair:
Robert Gauss

Associate Chair:
Melody (Mindy) Porterfield

Meeting Description

The Gordon Research Seminar on Glycobiology is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The aim of the meeting is to highlight recent advances in understanding the different processes of glycosylation, as well as the roles of glycans and glycoproteins in human diseases, immunology, gene expression, and epigenetics. Participants are encouraged to present their results of in vitro experiments or in vivo studies using viral, microbe, protozoan or metazoan model systems or give insight into novel methods and technologies to analyse glycan structure and function. A career development section will conclude the meeting.

Related Meeting

This GRS was held in conjunction with the "Glycobiology" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Final Meeting Program

Saturday
1:30 pm - 4:30 pmArrival and Check-in
3:00 pm - 3:15 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:15 pm - 4:00 pmRegulation of Glycosylation by Signaling Pathways
Discussion Leader: Maria Mayan (Fundación Profesor Novoa Santos, Spain)
3:15 pm - 3:25 pmFlavio Schwarz (University of California, San Diego, USA)
"CD33-Related Siglec Receptors Impact Mammalian Lifespan by Modulating Oxidative Stress"
3:25 pm - 3:30 pmDiscussion
3:30 pm - 3:40 pmSamuel Schmidt (Radboud Institute for Molecular Life Sciences, The Netherlands)
"Glycocalyx-Mediated Integrin-Independent Amoeboid Cell Migration"
3:40 pm - 3:45 pmDiscussion
3:45 pm - 3:55 pmKatherine Bonnington (Duke University, USA)
"A New Role for Outer Membrane Vesicles in the Outer Membrane Remodeling of Gram-Negative Bacteria"
3:55 pm - 4:00 pmDiscussion
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmGenetic Disorders, Immunology and Glycosylation in Non-Vertebrates
Discussion Leader: Oliver Grant (University of Georgia, USA)
5:30 pm - 5:40 pmIeva Bagdonaite (University of Copenhagen, Denmark)
"A Strategy for O-Glycoproteomics of Enveloped Viruses – The O-Glycoproteome of Herpes Simplex Virus Type 1"
5:40 pm - 5:45 pmDiscussion
5:45 pm - 5:55 pmBaerbel Blaum (University of Tuebingen, Germany)
"Structural Basis for Sialic-Acid Mediated Self-Recognition by Complement Factor H"
5:55 pm - 6:00 pmDiscussion
6:00 pm - 6:10 pmKshitij Khatri (Boston University, USA)
"Glycoproteomics of Influenza A Virus Hemagglutinin: Correlating Glycan Macro- and Micro-Heterogeneity with Virus Evolution and Interactions with the Host Immune System"
6:10 pm - 6:15 pmDiscussion
6:15 pm - 6:25 pmCorinna Landig (University of California, San Diego, USA)
"The Human-Specific Pathogen Neisseria gonorrhoeae Engages Innate Immunoregulatory Siglec Receptors in a Species-Specific Manner"
6:25 pm - 6:30 pmDiscussion
6:30 pm - 6:40 pmGeneral Discussion
6:40 pm - 6:50 pmMaria Mayan (Fundación Profesor Novoa Santos, Spain)
"Therapeutic Potential of Targeting Sialic Acid Modified Receptors in Osteoarthritis"
6:50 pm - 6:55 pmDiscussion
6:55 pm - 7:05 pmChristopher Adams (National Institutes of Health, USA)
"Intragenic Recombination: A Mechanism of Survival for Type IIb and Other Congenital Disorders of Glycosylation"
7:05 pm - 7:10 pmDiscussion
7:10 pm - 7:20 pmHeli Elovaara (University of Turku, Finland)
"Characterization of the Interaction Between Sialic Acid Binding Immunoglobulin-Like Lectin-9 and Primary Amine Oxidase"
7:20 pm - 7:25 pmDiscussion
7:25 pm - 7:30 pmGeneral Discussion
8:00 pmDinner
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amChemical and Molecular Analysis of Glycosylation in Health and Disease
Discussion Leader: Kshitij Khatri (Boston University, USA)
9:00 am - 9:10 amMariska Davids (National Institutes of Health, USA)
"Protein Glycosylation: A Factor in the Pathology of PLAN?"
9:10 am - 9:15 amDiscussion
9:15 am - 9:25 amSandra Carvalho (IPATIMUP, Portugal)
"Site-Specific Glycosylation Modification of E-Cadherin Impairs Its Biological Functions in Cancer Progression"
9:25 am - 9:30 amDiscussion
9:30 am - 9:40 amMichael Rugen (John Innes Centre, United Kingdom)
"Starch Metabolism in Germinating Cereals: Limit Dextrinase, the Debranching Enzyme"
9:40 am - 9:45 amDiscussion
9:45 am - 9:55 amOliver Grant (University of Georgia, USA)
"Understanding Site Specific N-Glycan Processing at the Molecular Level via Computational Glycobiology"
9:55 am - 10:00 amDiscussion
10:00 am - 10:10 amGeneral Discussion
10:10 am - 10:20 amAnna Rommel (University of Zurich, Switzerland)
"Characterization of Putative Glycosyltransferases in Giant Acanthamoeba Polyphaga Mimivirus"
10:20 am - 10:25 amDiscussion
10:25 am - 10:35 amTimm Fiebig (Hannover Medical School, Germany)
"The Capsule Polymerases of Neisseria meningitidis Serogroup A (CsaB) and X (CsxA) Have the Potential to Facilitate Vaccine Production in the Future"
10:35 am - 10:40 amDiscussion
10:40 am - 10:50 amNarine Arabyan (University of California, Davis, USA)
"Salmonella Degrades the Host Glycocalyx Leading to Altered Infection and Glycan Remodeling"
10:50 am - 10:55 amDiscussion
10:55 am - 11:00 amGeneral Discussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmMentorship Component: Career Mentoring
Discussion Leader: Flavio Schwarz (University of California, San Diego, USA)
1:30 pm - 1:35 pmIntroduction by Discussion Leader
1:35 pm - 2:25 pmPanel Discussion
"Career Mentoring"
  • Takashi Angata (Academia Sinica, Taiwan)
  • Pascal Gagneux (University of California, San Diego, USA)
  • Kelley Moremen (University of Georgia, USA)
2:25 pm - 2:30 pmClosing Remarks
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes

Funding for this conference was made possible (in part) by 1R13GM105060 - 01 from National Institute of General Medical Sciences. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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