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Carbohydrates (GRS)
Gordon-Kenan Research Seminar

Investigating the Roles of Carbohydrates in Disease: Synthesis, Analysis and Biological Conjugation

Dates

June 24-25, 2017

Location

Mount Snow
West Dover, VT

Organizers

Chairs:
Alyssa L. Pirinelli & Christian Toonstra

Meeting Description

The first meeting of the Gordon Research Seminar (GRS) on complex carbohydrates is a unique opportunity for young scientists (graduate students, post-docs, and early faculty) to present and exchange cutting-edge research and ideas in an environment mainly consisting of their direct peers.

Posters and talks presented at this GRS will focus on the study of carbohydrate chemistry and biology, looking at areas such as synthesis as well as glycans' behavior both in vivo and in silico, among many more. As a specific draw for younger scientists who are as of yet undecided of their future careers, this GRS features a Career Panel of successful members of both traditional and "non-traditional" science-related career paths.

Related Meeting

This GRS was held in conjunction with the "Carbohydrates" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Meeting Program

Saturday
2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmKeynote Session: Chemical, Biological, and Systems-Based Methods for the Study of Glycosylation
Discussion Leader: Alyssa Pirinelli (University of Minnesota Morris, USA)
3:45 pm - 4:20 pmLara Mahal (New York University, USA)
"Cracking the Glycocode"
4:20 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmUncovering the Role of Carbohydrates in Immunology
Discussion Leaders: Christian Toonstra (Johns Hopkins University, USA) and Klare Lazor (University of Delaware, USA)
7:30 pm - 7:50 pmHelene Pfister (National Institutes of Health, USA)
"Neutralization of Neuropathy-Inducing Anti-MAG Antibodies by Multivalent Glycoconjugates"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmRaiees Andrabi (The Scripps Research Institute, USA)
"Glycans as Anchors for Inducing HIV Broadly Neutralizing Antibodies"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:40 pmKelly Craft (Vanderbilt University, USA)
"Human Milk Oligosaccharides and Their Effect on Group B Streptococcus"
8:40 pm - 8:45 pmDiscussion
8:45 pm - 8:55 pmWei Qin (Peking University, China)
"O-GlcNAc Regulates Box C/D snoRNP Biogenesis by Stablizing the Core Components"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmJason Labonte (Johns Hopkins University, USA)
"RosettaCarbohydrate: A Framework for Residue-Centric Modeling and Design of Saccharide and Glycoconjugate Structures"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmKatelyn Erickson (University of North Carolina at Charlotte, USA)
"Development and Analysis of a Novel Targeting Strategy for Bacterial Sugars"
9:25 pm - 9:30 pmDiscussion
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amComplex Carbohydrates: Using Chemistry to Answer Critical Biological Questions
Discussion Leaders: Matthew Zhou (Stanford University, USA) and Teodora Kljaic (University of Maryland, USA)
9:00 am - 9:20 amBenjamin Schumann (Stanford University, USA)
"Glycosyltransferase Bump-Hole Engineering to Dissect Mucin-Type O-Glycosylation in Living Cells"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amShonoi Ming (U.S. Food and Drug Administration, USA)
"Mechanism of Action of Neisseria Meningitis C Polysialyltransferase"
9:50 am - 10:00 amDiscussion
10:00 am - 10:10 amRegis Saliba (Indiana University, USA)
"Challenges in the Automated Solution Phase Syntheses of Potential Immunological Oligosaccharide Adjuvants"
10:10 am - 10:15 amDiscussion
10:15 am - 10:25 amEric Sletten (University of Iowa, USA)
"Neo-Glycopolymer Heparan Sulfate Polysaccharide Mimics as Potent Tight-Binding Inhibitors of Heparanase"
10:25 am - 10:30 amDiscussion
10:30 am - 10:40 amShifra Lansky (The Hebrew University of Jerusalem, Israel)
"Multiple Conformational States of a Unique Extracellular Arabinanase Suggest a 'Harpoon' Mechanism of Action"
10:40 am - 10:45 amDiscussion
10:45 am - 10:55 amJenna DeSousa (Vanderbilt University, USA)
"Studies Towards the Total Synthesis of Arimetamycin A and Its Biological Disaccharide"
10:55 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmMentorship Component: Career Panel
Discussion Leaders: Victoria Kohout (Indiana University, USA) and Ross Mancini (University of Toronto, Canada)
1:30 pm - 2:30 pmPanel Discussion
"Careers in Academic, Government, and Primarily Undergraduate Institutions"
  • Catherine Grimes (University of Delaware, USA)
  • Nicole Snyder Lee (Davidson College, USA)
  • Steven Townsend (Vanderbilt University, USA)
  • Willie Vann (U.S. Food and Drug Administration, USA)
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes
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