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Protein Folding Dynamics (GRS)

Gordon Research Seminar

Artificial Intelligence, Design, Evolution, and Emergent Phenomena at the Mesoscale

January 3 - 4, 2026

Chairs

and

Sheraton Fairplex Hotel & Conference Center

601 West McKinley Ave.

Pomona, California, United States

Venue and Travel Information

Conference Description

The Protein Folding Dynamics GRS provides a unique forum for young doctoral and post-doctoral researchers to present their work, discuss new methods, cutting edge ideas, and pre-published data, as well as to build collaborative relationships with their peers. Experienced mentors and trainee moderators will facilitate active participation in scientific discussion to allow all attendees to be engaged participants rather than spectators.

The 2026 Gordon Research Seminar on Protein Folding Dynamics is the premier forum offering graduate students, postdocs, and early-career researchers from diverse scientific backgrounds—including biology, biophysics, chemistry, computer science, and mathematics—to engage in cutting-edge discussions and share work and ideas creating a unique atmosphere for ideation, connection, and collaboration.The Protein Folding Dynamics GRS will highlight exciting advances in artificial intelligence and machine learning, the interplay between evolution, folding, and design, and its critical role in shaping the emergence of mesoscale phenomena. Whether you are unraveling the mysteries of protein dynamics or developing new computational tools, this seminar offers an unparalleled opportunity to engage, inspire, and innovate in a welcoming, trainee-focused setting.

Related Meeting

This GRS will be held in conjunction with the "Protein Folding Dynamics" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
1:00 pm - 5:00 pm	Arrival and Check-in
3:30 pm - 3:45 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm	Protein Folding and Conformational Heterogeneity Discussion Leader:
3:45 pm - 3:55 pm	"Conformational Heterogeneity in Leptin Reveals Hidden Structural States"
3:55 pm - 4:00 pm	Discussion
4:00 pm - 4:10 pm	"What do Unfolded Outer Membrane Protein (uOMP) Ensembles Look Like?"
4:10 pm - 4:15 pm	Discussion
4:15 pm - 4:25 pm	"Towards a Detailed Molecular Picture of Co-translational Protein Folding During Real-time Translation"
4:25 pm - 4:30 pm	Discussion
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Protein Folding, Evolution, and Design: From Molecular Structure to Phenotype Discussion Leaders: and
7:30 pm - 7:40 pm	"Surveying the Sequence Constraints of Folding on the Ribosome by Deep Mutational Scanning"
7:40 pm - 7:45 pm	Discussion
7:45 pm - 7:55 pm	"Stability vs. Environmental Sensitivity: The Trade-off Faced by Protein Surface Residues"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 8:10 pm	"Principles of Biophysical Fitness Landscape Design"
8:10 pm - 8:15 pm	Discussion
8:15 pm - 8:25 pm	"Mapping Protein Reactivity In High-Throughput: Linking SpyCatcher Sequence to Function"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:40 pm	"High-throughput in Vitro Measurements of Library-on-Library Protein Nucleic Acid Binding Interactions via STAMMP-seq"
8:40 pm - 8:45 pm	Discussion
8:45 pm - 8:55 pm	"Engineering Stability in a Rotary Protein Machine: Disulfide Crosslinking Illuminates the Dynamics-stability Interplay in F1-ATPase"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	"Native Non-covalent Lasso Entanglement Promotes Misfolding and Contributes to Age-related Structural Change in the Saccharomyces Cerevisiae Proteome"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	"A Covariant Language Model (CLM) to Improve CO2 Fixation in Rubisco"
9:25 pm - 9:30 pm	Discussion
Sunday
7:30 am - 8:30 am	Breakfast
9:00 am - 11:00 am	Accelerating Protein Folding and Dynamics Discovery with AI and Machine Learning Discussion Leaders: and
9:00 am - 9:30 am	"Design of Therapeutics to Conformationally Diverse Substrates via Generative Sequence Models"
9:30 am - 9:35 am	Discussion
9:35 am - 9:45 am	"Open Ended Complexes: Integrative Structural Ensembles of Host-viral Complexes from HDX-MS"
9:45 am - 9:50 am	Discussion
9:50 am - 10:00 am	"AlphaFold Uses Sparse Sequence Patterns to Predict Protein Conformations"
10:00 am - 10:05 am	Discussion
10:05 am - 10:15 am	"Membrane to Protein: "All I Need is Your Attention!""
10:15 am - 10:20 am	Discussion
10:20 am - 10:50 am	"Inferring Compositional and Conformational Probability Distributions Using CryoEM Images"
10:50 am - 10:55 am	Discussion
10:55 am - 11:00 am	General Discussion
11:00 am - 12:30 pm	Poster Session Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm	Lunch
1:30 pm - 2:30 pm	Mentorship Component: Academia and Beyond: Exploring Diverse Career Paths Discussion Leaders: and
1:30 pm - 2:30 pm	Panel Discussion Exploring Diverse Career Paths
2:30 pm - 3:00 pm	Evaluation Period Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm	Seminar Concludes

Contributors

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Conference History Protein Folding Dynamics

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