Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
7:40 pm - 8:00 pm
"Oncofetal Chondroitin Sulfate as a Target for Cancer Therapy and Diagnosis"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:20 pm
"Uncovering the Role of Heparan Sulfate Proteoglycans in Exosome Biogenesis: Potential Tools for Improved Therapies"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
"CD44 Forms Transmembrane Pickets that Act as Barriers to Receptor Engagement"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:05 pm
"Biglycan Regulates Macrophage Infiltration During Fracture Healing via Interaction with NOX2 and Expression of IL-6"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Analysis of Glycosaminoglycans Using Systems Medicine Approaches for Cancer Diagnostics"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:20 am
"Interactions Between Biosynthesis Enzymes and the Control of Heparan Sulfate Structure"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
"Epithelial Deletion of Sulf2 Alters Alveolar Structure and Gene Expression in the Lung"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Heparan Sulfate Proteoglycans Capture and Present PCSK9 to the LDL Receptor"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Motif Enrichment Analysis Uncovers Novel Transcriptional Regulators of Heparan Sulfate Assembly"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Enzymology and Cell Biology of the Novel Cell Surface Hyaluronidase TMEM2"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Glycosite-Specific Identification of Glycosaminoglycans: Expanding the Chondroitin Glycoproteome of Caenorhabditis elegans "
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"The Mammalian Chondroitinase, Hyaluronidase 4, Is Produced by Human Mast Cells and Generates Chondroitin Sulfate Cleavage Neo-Epitopes"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Crystal Structure of Dermatan Sulfate Epimerase 1 and Its Interaction with Dermatan Sulfate 4-Sulfotransferase"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Proteoglycans in Cell Metabolism, Autophagy and Oxidative Stress
7:30 pm - 7:50 pm
"Heparan Sulfate Biosynthesis Regulation of Autophagy Affects Lifespan, Responses to ROS Stress and Neurodegeneration"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Role of Hyaluronan in Metabolic Reprogramming of Cancer Stem Cells"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Autophagic Modulation of HAS2 in Endothelial Cells"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"Hepatic Heparan Sulfates in the BMP/SMAD Pathway and Their Effect on Hepcidin Expression and Iron Metabolism"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Brown Adipose Tissue Hyperactivity in Lysosomal Storage Disorders Due to Impaired Mitophagy"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Proteoglycan-Based Technologies and Treatments
9:00 am - 9:20 am
"Assignment of Site-Specific Glycosylation in Complex Proteoglycan Samples"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
"First Clinical Experience with a Novel Glycan Therapeutic, SB-030: SHIELD Trial Results for Peripheral Artery Disease Intervention"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Use of Biotechnology for the Engineering of Native and Novel Proteoglycans"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Metalloglycomics: The Therapeutic Potential of Cobalt Through Glycan Binding"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Development of Recombinant Human Proteoglycan 4 (Lubricin) for the Treatment of Dry Eye and Other Diseases"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Structurally Defined Heparan Sulfate Protects from Acetaminophen-Induced Acute Liver Failure"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Mass Spectrometry Sequencing Tools for Glycosaminoglycans"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Cell Capture to the Blood Vessel Wall: The Influence of HA Softness on Its Interactions Under Flow"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Proteoglycans in Development, Musculoskeletal and Aging Biology
7:30 pm - 7:50 pm
"Unexpected Roles for Aggregating Proteoglycans and Their Processing by ADAMTS Proteases in Development"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
"BCP Crystals Induce H6ST1 Expression and Bind Wnt3a at Their Surface, Thereby Promoting Chondrocyte Hypertrophic Differentiation in OA Cartilage"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Role of Heparan Sulfate Proteoglycans in Cellular Migration"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Understanding the Pathogenesis of Ehlers-Danlos Syndrome, a Rare Connective Tissue Disorder Caused by B3GALT6 Mutations: What if 'Omics' Could Help?"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Hyaluronan Degradation by HYAL2 in Human and Mouse Development"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Proteoglycans in Fibrosis, Inflammation and Infectious Disease
9:00 am - 9:20 am
"LYVE-1: Leucocyte-Hyaluronan Interactions in Lymphatic Trafficking"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
"Heparan Sulphate Oligosaccharides as Novel Biomarkers in Inflammatory Renal Diseases"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Choosing a Partner: Chemokine Interactions with Receptors and Glycosaminoglycans"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Platelet Hyaluronidase-2 Regulates Inflammation by Modulating Immune Cell Binding and Extravasation Across the Endothelium"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Altered Hyaluronan Synthesis and Assembly: A Role in Dysregulated Scarring and Fibrosis"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Multiplexed Imaging of Extracellular Matrix Proteoglycans in Autoimmune Insulitis"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Expression and Function of Human Macrophage Heparan Sulphate Proteoglycans"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Mass Spectrometry Profiling of the In Vivo Vascular Glycoproteome During Systemic Inflammation and Sepsis"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Proteoglycans in Cell Signalling and Trafficking
7:30 pm - 7:50 pm
"The Molecular Mechanisms Underlying Hyaluronan-Mediated Signalling in Cancer"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
"HS and CS Mediate Wnt/β-Catenin Signaling by Presenting Wnts and R-Spondins"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
"Mechanobiology of Hyaluronan-Mediated Cell Adhesion and Migration"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 9:00 pm
"What Have the Syndecans Ever Done for Us? Insights into Proteoglycan Structure/Function Relationships"
9:00 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Role of Heparan Sulfate in Indian Hedgehog Signaling and Glycosaminoglycan Composition"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Proteoglycans in Tissue Engineering and Regenerative Medicine
9:00 am - 9:20 am
"Creating Proteoglycan-Defined Cell Environments to Model Disease and Development and to Drive Differentiation"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
"Versican Is Differentially Regulated in the Adventitial and Medial Layers of Human Vein Grafts"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Tissue Regenerative Properties of Hyaluronan/Protein Complexes Isolated from Human Amniotic Membrane and Umbilical Cord"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
"A Syndecan-TRP Channel Axis Controls Germline Stem Cell Development"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Chemical Remodeling of the Proteoglycan Glycocalyx to Influence Cellular Differentiation"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Patch Grafting Strategies for Transplantation of Stem/Progenitors into Internal Organs"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"A Synthetic Heparan Sulfate Mimetic for Enhancing BMP-2-Mediated Osteogenesis"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"A Hyaluronan-RHAMM Axis Is Required for Prompt Regeneration After Acute Liver Injury in Mice"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Proteoglycans in Cancer and Neural Biology
7:30 pm - 7:50 pm
"Modulation of Chondroitin Sulfates in Perineuronal Nets for Memory Enhancement in Aging"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
"Persistent Neurocognitive Dysfunction After Sepsis Is Mediated by NS/2S-Rich Heparan Sulfate Fragments Released During Septic Endothelial Glycocalyx Degradation"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
"Hippocampal Heparan Sulfate Proteoglycans in a Novel Rodent Model of Mood Disorders"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"A Role for the Serglycin-Tryptase Axis in Regulating Proliferation of Melanoma Cells"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Glypican-2 as a Target for Neuroblastoma Immunotherapy"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Heparan Sulfate Regulates Breast Cancer Stem Cell Phenotype and Chemosensitivity"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure