Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Unveiling Protease Frontiers
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
"Microbial Proteases and their Roles in Regulation of Pain and Inflammation in the Gut"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"An Interplay between Proteases: DPP9 as a Regulator of Non-Lysosomal Cathepsins"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Caspase-1 self-terminates protease activity to enforce homeostasis and prevent inflammasome-driven diseases"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
"Structural Insights for Plasmodium Proteasome Inhibitor Design"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
"New Paradigm of Substrate Allostery Revealed by Structures of Prothrombinase with Prothrombin and Meizothrombin"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Dynamic Landscapes in Protease Biology
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Differential Dynamics in Caspase-6 Impact and Guide Development of Selective Inhibitors"
9:25 am - 9:30 am
Discussion
9:30 am - 9:50 am
"DIPTAR: A Synthetic Biology Platform for Generating Functional Pattern Recognition Receptors that Activate the Innate Immune System"
9:50 am - 9:55 am
Discussion
9:55 am - 10:10 am
"Peptide Modulators Target the Non-Catalytic Activity of Human Prolyl Oligopeptidase"
10:10 am - 10:15 am
Discussion
10:15 am - 10:30 am
"Structure and Function of a Multi-Megadalton Virus-Like Proteolytic Dodecahedron"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
"Caspase-4 Is an Intracellular Heme Receptor"
11:25 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Isotope-Enhanced Chemoproteomic Profiling of Endogenous Protein Serotonylation"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"MT1-MMP: A Key Factor in Neuroinflammation-Induced Cognitive Impairment"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Next-Generation Inhibitors and Modulators
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:25 pm
"Neutrophil Serine Proteases as Determinants of Neutrophil Heterogeneity and Function"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Next-Generation Strategies in Protease Substrates and Inhibitors Design"
6:50 pm - 6:55 pm
Discussion
6:55 pm - 7:10 pm
"mRNA Display with Genetic Reprogramming for the Discovery of Potent and Selective Inhibitors of Coagulation Proteases"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:30 pm
"Linear Peptides Protect Fibrinolysins From Plasminogen Activator Inhibitor 1 and Increase the Efficacy of sctPA in a Rabbit Model of Acute Empyema"
7:30 pm - 7:35 pm
Discussion
7:35 pm - 7:50 pm
"Discovery of a Selective, Noncovalent TMPRSS12 Inactivator for Non-Hormonal Contraception"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Proteases in Health and Disease Progression
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Ectodomain Shedding of Membrane Proteins: from Regulatory Mechanisms to Clinical Trials"
9:25 am - 9:30 am
Discussion
9:30 am - 9:50 am
"The Cannonical and Non-Cannoical Functions of the Proprotein Convertases"
9:50 am - 9:55 am
Discussion
9:55 am - 10:10 am
"Role of Mast cell Chymase Proteolysis in Ulcerative Colitis"
10:10 am - 10:15 am
Discussion
10:15 am - 10:30 am
"SpyCEP Dismantles Neutrophil Immunity via Disorder-Driven Chemokine Remodeling and GAG Targeting"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
"Multimodal Protease Activity Profiling for Precision Oncology"
11:25 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Multimodal Proteomics Reveals an HTRA1-Activity Signature Reflecting Monocyte Inflammation in Human Eye and Joint Liquid Biopsies"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Targeting Proteases in Colorectal Cancer: Uncovering Mechanisms and Therapeutic Opportunities"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Multifunctional Protease Roles
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:25 pm
"Cathepsin Drugs - What is the Future?"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Non-Canonical Roles for Not-Always-So-Lysosomal Proteases"
6:50 pm - 6:55 pm
Discussion
6:55 pm - 7:15 pm
"Molecular Basis of Allosteric Inhibition of Human β-Tryptase by Exosite-Binding Antibodies"
7:15 pm - 7:20 pm
Discussion
7:20 pm - 7:35 pm
"Cathepsin D Is a Smart Multifaceted Protease for Antibody-Based Therapies To Trigger Antitumor Innate and Adaptive Immunity, and for Antibody-Drug Conjugates To Deliver Vectorized Chemotherapy"
7:35 pm - 7:40 pm
Discussion
7:40 pm - 7:55 pm
"Cryo-EM Structure of CLCA1 Identifies CLCA1 as a Founding Member of a Novel Metzincin Family"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Targeting Proteolysis - Mechanism to Molecules
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Moonlighting Functions of Miropin, a Bacterial Serpin Secreted by Tannerella Forsythia"
9:25 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Navigating Chemical Space in the Discovery of Parasite Protease Inhibitors"
9:50 am - 9:55 am
Discussion
9:55 am - 10:10 am
"A Proteolytic Trojan Horse in the Global Ocean: Viral NblA Hijacks a Cyanobacterial Stress Adaptor"
10:10 am - 10:15 am
Discussion
10:15 am - 10:30 am
Late-Breaking Topic
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:20 am
"Targeting the Proteasome for Ubiquitin-Independent Protein Degradation"
11:20 am - 11:25 am
Discussion
11:25 am - 11:40 am
"Developing Optical Sensors to Monitor Protease Activity in Breast Cancer"
11:40 am - 11:45 am
Discussion
11:45 am - 12:00 pm
Late-Breaking Topic
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Omic Innovations in Protease Research
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:25 pm
"Beyond the Cellular Boundary: The Expanding World of Protein Degradation"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"N-Terminal Proteomics in 4D"
6:50 pm - 6:55 pm
Discussion
6:55 pm - 7:10 pm
"A KLK3 (PSA) Missense Variant Links Protease Rewiring to Prostate Cancer Metastasis"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:30 pm
"Caspase-Mediated Cleavage Events Hidden by Secondary Proteolysis"
7:30 pm - 7:35 pm
Discussion
7:35 pm - 7:50 pm
"Degradomic Analysis of Infected Macrophages Identifies New Functions for the African Swine Fever Virus Protease pS273R"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Translating Protease Science to Therapeutic Solutions
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Nature Knows Best: Biomimetic Nano Strategies for Therapeutic Intervention"
9:25 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Harnessing Protease Activity of the Tumor Microenvironment with RIPs as a Novel Modality to Deliver Targeted Radiotherapeutics"
9:50 am - 9:55 am
Discussion
9:55 am - 10:10 am
"USP25/28 Inhibitors With Improved Selectively Towards C-Myc Driven Squamous Lung Cancer Cells"
10:10 am - 10:15 am
Discussion
10:15 am - 10:30 am
Short Talk Selected from Poster Abstracts
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:20 am
"Exploiting Biofilm-Specific Proteases for Narrow Spectrum Antimicrobial Peptide Development"
11:20 am - 11:25 am
Discussion
11:25 am - 11:40 am
"Identifying Indole Framework Aza-peptide Epoxides as Potent SARS-CoV-2 Main Protease Inhibitors"
11:40 am - 11:45 am
Discussion
11:45 am - 12:00 pm
"SmolCathL2 of the Ancient Endoparasite Sphaerospora molnari Is a Crucial Hemoglobinolytic Peptidase and Promising Therapeutic Target"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Keynote Session: Future Horizons in Protease and Inhibitor Research
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:25 pm
"Probing Proteases: From Discovery to Therapeutics"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:45 pm
"Craspase Is an RNA-Guided and SNP-Sensitive Programmable Protease System"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:05 pm
"Development of Granzyme-Targeting Probes for Assessing Tumor Response to Immunotherapy"
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:25 pm
Late-Breaking Topic
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Identification of a Potent Pan-coronaviral Inhibitor Targeting Zoonotic Viral Proteases"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure