Chair: Alan D'Andrea
|SUN pm |
|Red Cell Disorders|
- Alan D'Andrea (Boston Children's Hospital, Boston, MA): Fanconi Anemia proteins.
- Paul Ney (St. Jude Children's Research Hospital, Memphis, TN): Friend erythroleukemia.
- Kasturi Haldar (Northwestern University, Chicago, IL): Erythrocyte rafts and malarial infection.
- Nancy Andrews (Boston Children's Hospital, Boston, MA): Mouse models of human iron disorders.
Chair: Connie Noguchi
|Erythroid Gene Expression I |
- Short talk: Connie Noguchi (NIH, Bethesda, MD): Tal1 binding to centromeric satellite DNA: A new role for Tal1 in transcription repression
- Jim Bieker (Mt. Sinai School of Medicine, New York, NY): EKLF-dependent gene transcription.
- James Shen (Academica Sinica, Taipei, Taiwan): Enhanceosomes and Promoteosomes of the Mammalian Globin Gene Loci.
- Gerd Blobel (Children's Hospital, Philadelphia, PA): Transcription factors and their coactivators: a two-way street.
- Dorothy Tuan (Medical College of Georgia, Augusta, GA): A transcription mechanism of HS2 enhancer/LCR function.
- Peter Fraser (Babraham Institute, Babraham, UK): Intergenic transcription and developmental remodeling within the human ß-globin gene locus.
- Emery Bresnick (Univ. Wisconsin, Madison, WI): Coactivator requirements for ß-globin LCR enhancer function.
- Short talk: Klaus Scherrer (Institut Jacques Monod, Paris, France): The Full Domain Transcript (FDT) and novel features of control in the Chicken alpha-globin gene domain.
Chair: Sam Lux
| Membrane Structure, Transport and Adhesion|
- CH Huang (New York Blood Center, New York, New York): Identification of Rhit as a new member of the HIT family that interacts with Rh glycoproteins.
- John Gibson (University of Liverpool, Liverpool, UK): Oxygen sensitive membrane transport in vertebrate red cells.
- Leslie Parise (University of North Carolina at Chapel Hill): Newly identified mechanisms of RBC adhesion mediated by signaling pathways-Part I
- Marilyn Telen (Duke University, Durham, NC): Newly identified mechanisms of RBC adhesion mediated by signaling pathways-Part II.
- Carolyn Enns (Oregon Health Sciences University, Portland, Oregon): Interactions of HFE with the transferrin receptor.
Chair: Narla Mohandas
|Membrane Structure and Mechanics|
- Narla Mohandas (Lawrence Berkeley National Laboratory, Berkeley CA): Crystal structure of protein 4.1 30 kD domain.
- Yuichi Takakuwa (Tokyo Women's Medical University): Interaction of protein 4.1R with phosphatidylserine.
- Ed Benz (Dana Farber, Boston, MA): Functions of Protein 4.1R in non-erythroid tissues
- Dennis Discher (University of Pennsylvania, Philadelphia, PA): Spectrin unfolding.
- Phil Low (Purdue University, W. Lafayette, IN): Function and regulation of erythrocyte membrane-skeleton interactions.
- David Golan (Brigham & Women's Hospital, Boston, MA): Single molecule studies of membrane protein dynamics in intact human and mouse red cells.
- Velia Fowler (Scripps Research Institute, La Jolla, CA) Tropomodulin structure/function and isoforms.
Chair: Dorothy Tuan
| Erythroid Gene Expression II |
- Frank Grosveld (Erasmus University, Rotterdam, The Netherlands): LCR-regulated ß-globin transcription.
- Keith Byrd (Johns Hopkins Univ. Baltimore, MD): Chromatin Insulators and Nuclear Organization.
- M. Bender (Fred Hutchinson Cancer Research Center, Seattle, WA): Activities of the Endogenous LCR.
- Doug Engel (Northwestern University, Evanston, IL): Transcription factor collisions inside red cells.
Chair: Jon Morrow
| Erythrocyte Membrane Proteins and their Isoforms in Intracellular Membrane Systems |
- Keynote Speaker: Jennifer Lippincott-Schwartz (NICHD, NIH, Bethesda, MD): Protein Trafficking and organelle dynamics in living cells.
- Vann Bennett (Duke University, Durham, NC):Role of ankyrin-B in post-Golgi vesicle targeting.
- Peter Michaely (UT Southwestern Medical Center, Dallas, TX): Structure of the ANK repeats of ankyrin.
- Jon Morrow (Yale University, New Haven, CT): Spectrin and ankyrin dependent organelle trafficking
- Sam Lux (Children's Hospital, Boston, MA): Spectrin IV
Chair: Nancy Speck
|Erythroid Development |
- Stu Orkin (HHMI, Children's Hospital, Boston, MA): Transcriptional control of hematopoiesis.
- Gillian May (Institute of Cancer Research, London, UK): Lineage programming and reprogramming by GATA-1.
- Masi Yamamoto (Univ. Tsukuba, Tsukuba, Japan): In vivo Requirements for GATA-1 Functional Domains During Primitive and Definitive Erythropoiesis.
- David O'Neill (Columbia University, New York, NY): Fetal liver hematopoiesis in Ikaros-deficient mice.
Chair: Len Zon (HHMI, Children's Hospital, Boston, MA).
| Hematopoiesis |
- Len Zon (HHMI, Children's Hospital, Boston, MA): Hematopoietic development in the zebrafish.
- Shuo Lin (Medical College of Georgia, GA): Genetic studies of Protein 4.1 in zebrafish
- Roger Patient (University of Nottingham, UK): The origins and programming of red cells in Xenopus and zebrafish.
- Connie Lane (Univ. of Wisconsin): Primitive and definitive blood compartments share a common origin in Xenopus.
- Margaret Baron (Mt. Sinai School of Medicine, New York, NY): Endoderm-mesoderm interactions in hematopoiesis and vasculogenesis.
- Kyunghee Choi (Washington Univ. St. Louis, MO): Defining the hemangioblast: a common precursor of hematopoietic and endothelial cells.
- Short talk: Kim Dooley (HHMI, Children's Hospital, Boston, MA): A Forward Genetic Approach in Zebrafish to Study Early Hematopoiesis.
- Nancy Speck (Dartmouth Univ., NH): The Runx1-CBFb transcription factor and its role in hematopoietic stem cell emergence.
Chair: Joyce Lloyd
|Late Breaking Stories/Selected Talks from Abstracts|
- Joyce Lloyd (Virginia Commonwealth University, Richmond, VA): Roles of the Gamma-Globin CACCC and TATA sequences in suppression of the beta-globin gene early in development.
- Jeff Miller (NIH, Bethesda, MD): Cytokine-mediated modulation of hemoglobin production in primary human erythroid cells.
- Luanne Peters (Jackson Laboratory, Bar Harbor, ME): Genetic modifiers of the band 3 null phenotype.
- John Conboy (Lawrence Berkeley National Laboratory, Berkeley CA): Developmental changes in hnRNP A/B protein expression during erythropoiesis regulate Protein 4.1R alternative pre-mRNA splicing.
- Pat Gallagher (Yale University, New Haven, CT): Regulation of erythrocyte membrane gene expression.
- Dave Bodine (NIH, Bethesda, MD): Characterization of red cell membrane promoters and applications to globin gene therapy.