Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Developmental Erythropoiesis
7:40 pm - 8:00 pm
"TIF1γ Transcriptionally Regulates Mitochondrial Metabolic Pathways to Drive Erythropoiesis"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"Regulation of Definitive Erythroid Progenitor Development by the Vitamin D Receptor Transcription Factor"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Single Cell Approaches to Study Normal and Failed Hematopoiesis"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Transcriptional Signaling Centers During Human Erythropoiesis"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Epigenetics of Erythropoiesis
9:00 am - 9:20 am
"Epigenetic Regulation of Erythroid Gene Expression"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"New Insights into Gene Regulation Based on Multi-Way Chromatin Interactions at Single Alleles"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Activated Erythroid Gene Expression by Ubiquitin-Mediated Proteolysis of a Transcriptional Repressor at Bivalent Chromatin"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"The Mechanisms by Which Enhancers Promote Transcription at the Globin Loci"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Multiplexed CAPTURE of the Dynamic 3D Epigenome During Erythropoiesis"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"New Insights into the Regulation of Gene Expression by the GATA1s Isoform"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Mass Spectrometry for Histone Posttranslational Modifications Reveals Novel Insights into Terminal Erythroid Maturation"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Infectious Diseases of the Erythrocyte
7:30 pm - 7:50 pm
"Vesicle-Mediated Antigen Export in Babesia Microti-Infected Erythrocytes"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Protection Against Severe Malaria: Red Blood Cell Tension, Plasmodium falciparum Invasion and Rare Glycophorin Variants"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"A New Therapy for Malaria: Mechanism and Early Clinical Results"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Determinants of Plasmodium falciparum Infection"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Dissecting the Mechanisms of Malaria Induced Anemia in Rodent Malaria Models"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Erythrocyte Disorders: Inherited and Acquired
9:00 am - 9:20 am
"Diamond Blackfan Anemia: Big Lessons from a Small Disease"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
"Regulation of Globin-Heme Balance in Diamond-Blackfan Anemia by HSP70/GATA1"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Piecing Together the Impact of Aberrant Splicing on Terminal Erythroid Maturation"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Hydroxyurea: How to Teach an Old Drug New Tricks"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Targeting Epigenetic Repressor Subunit Inactivation to Treat SCD"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"The Congenital Dyserythropoietic Anemias: From Basic Biology to Novel Therapeutic Strategies"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"MMS22L: A Novel Key Actor in Erythropoiesis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Iron and Heme Homeostasis
7:30 pm - 7:40 pm
"Hemozoin Produced by Mammals Confers Heme Tolerance"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Regulation of Erythroid Heme Synthesis by the Mitochondrial Protein Unfoldase, CLPX"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Congenital Sideroblastic Anemia: Iron and Heme Lost in Mitochondrial Translation"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"The Unexpectedly Important Role of Ferroportin Mediated Iron Export in Mature Red Cells"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"New Mechanisms Regulating Iron Homeostasis"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Erythropoiesis: Normal and Perturbed
9:00 am - 9:20 am
"A Congenital Hemolytic Anemia Dissociates the Pleiotropic Functions of a Master Transcription Factor"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Novel Function of MAEA (Erythroblast-Macrophage Protein) in Hematopoiesis"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Erythroblastic Island Macrophages: Identification and Functional Insights"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
"A Systems Approach to Identification of Cells in Erythro(myelo)blastic Islands"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
"New Insights into Human Erythroid Progenitors"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
"RASA3 Regulates Specific Patterns of Ras Signaling During Erythropoiesis"
11:40 am - 11:45 am
Discussion
11:45 am - 12:15 pm
"From Red Cells to White Cells and Back Again"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Disorders of the Erythrocyte and Emerging Therapeutics
7:30 pm - 7:50 pm
"Hemoglobin Switching via BCL11A"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"BCL11A as Target in Gene Therapy for Sickle Cell Disease"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"A Modified Gamma-Globin Gene and Reduced Intensity Conditioning Ameliorates Sickle Cell Disease"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"Mechanism of Action of Mitapivat (AG-348) in Hematological Disease"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Splenic Filtration of Storage-Induced Micro-Erythrocytes and Improvement of Transfusion Safety and Efficacy"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Gene Regulation in Erythroid Development and Differentiation
9:00 am - 9:20 am
"Comprehensive Integrated Genomic Perturbation to Investigate Molecular Mechanisms of RBC Trait Associations"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Elucidating Mechanisms Governing Progenitor Cell Fate and Erythrocyte Generation Through Multiomics"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Cell Cycle Specializations that Drive Early Erythroid Cell Fate Decisions: A Single-Cell Approach"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
"Regulation of Stress Erythropoiesis by Gdf15"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Delineating the Functions of EKLF During Terminal Erythroid Cell Divisions"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Epigenomic Analysis of KLF1 Haploinsufficiency in Primary Human Erythroblasts"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"KLF1 Pioneers for GATA1 and Associated Complexes at Key Erythroid Enhancers to Drive Red Blood Cell Differentiation"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Erythrocyte Membrane and Metabolism
7:30 pm - 7:40 pm
"Metabolism and Erythroid Differentiation"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 8:05 pm
"Metabolic Reprogramming Promotes Erythroid vs Myeloid Commitment Under Stress"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"mDia2 Modulates Cytoskeleton and Cytoplasmic Clearance During the Genesis of Reticulocyte"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"The Emerging Roles of Erythrocytes in the Regulation of Blood Flow in Microvessels"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Investigating the Impact of Deformation and Shear Stress on Erythroid Cells"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure