Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: RNA Editing and Modifications in Cancer
7:40 pm - 8:10 pm
"Targeting RNA Modifications in Cancer"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"Advances in Understanding the Molecular Mechanism of APOBEC Mutagenesis in Cancer"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"Co-Opting RNA Editing for Cancer Immunotherapy"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
"Tumor Warm-Up: Leveraging ADAR-Mediated Targeted RNA Editing to Induce Cancer Immunogenic "'Editopes'"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
RNA Editing and Modification in Development and Disease
9:00 am - 9:20 am
"Decoding Mechanism Mediated by tRNA Modifications"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
"Advances in Functional Understanding of Queuosine-tRNA Modification"
9:45 am - 9:50 am
Discussion
9:50 am - 10:00 am
"Edited Filamin A in Myeloid Cells Protects From Colitis"
10:00 am - 10:05 am
Discussion
10:05 am - 10:15 am
"The RNA Methyl-Transferase FTSJ1: Conserved Role in Neuron Morphology, Learning Performance and Translational Control"
10:15 am - 10:20 am
Discussion
10:20 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"RNA Editing and Immune Evasion: Insights into ADAR1’s Role in Cancer"
11:05 am - 11:10 am
Discussion
11:10 am - 11:30 am
"Exploring Editing Independent Functions of ADAR1"
11:30 am - 11:35 am
Discussion
11:35 am - 11:55 am
"Harnessing Epitranscriptomic Pathways for Anticancer Therapy via Functionalized Extracellular Vesicles"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Extrachromosomal DNA Formation Through APOBEC Deamination"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"An RNA Editing Approach for Treatment of Rett Syndrome"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
RNA Editing and Modifications Across Life
6:00 pm - 6:20 pm
"RNA Recoding of Microtubule-Based Motor Proteins"
6:20 pm - 6:25 pm
Discussion
6:25 pm - 6:45 pm
"Synthesis and Function of Wobble Base Modifications in tRNA"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:10 pm
"The Best of Two Worlds: RNAylation Covalently Links RNA to Proteins"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:35 pm
"A-to-I RNA Editing in Bacteria: Occurrence, Regulation, and Function"
7:35 pm - 7:40 pm
Discussion
7:40 pm - 7:50 pm
"Deciphering High-Level A-to-I RNA Recoding in Cephalopods"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Biological Functions of RNA Editing and RNA Modification
9:00 am - 9:20 am
"How do ADAR1 Mutations Cause Immunopathology"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
"m6 Am Sequesters its Reader to Suppress Premature Termination and Drive Neuroblastoma Differentiation"
9:45 am - 9:50 am
Discussion
9:50 am - 10:00 am
"MDA5-Associated Endogenous dsRNA Targets in hnRNPM-Deficient Cells and Immune Activation"
10:00 am - 10:05 am
Discussion
10:05 am - 10:15 am
"Unraveling the Interplay Between tRNA Epitranscriptome and Codon Bias in Development and Stress Responses"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"An Unexpected Role for the ADAR p150 and p110 Zβ Domain in Nonsynonymous Editing, and Alternative Splicing"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
"mRNAs Function as m5C Sponges to Reduce Cellular SAM Level in Response to Glucose Starvation"
11:35 am - 11:40 am
Discussion
11:40 am - 12:00 pm
"Decoding the Epitranscriptome at Single Molecule Resolution: Towards Clinical Applications"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:25 pm
"Controlling Vascularlzation and Bone Stiffness via RNA Editing"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Function and Applications of Epitranscriptomics
6:00 pm - 6:20 pm
"Charting the Dynamic rRNA Epitranscriptome"
6:20 pm - 6:25 pm
Discussion
6:25 pm - 6:45 pm
"tRNA Modifications and Translation Quality Control"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:10 pm
"Charting tRNA Modifications Across All Domains of Life: The Power of Combined OTTR-Seq and Nanopore Approaches"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:35 pm
"Engineering Covalent Small Molecule–RNA Complexes in Living Cells"
7:35 pm - 7:40 pm
Discussion
7:40 pm - 7:50 pm
"Coordinated Changes of tRNA Modifications for Protein Homeostasis"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
RNA Modification and Deamination Mechanisms
9:00 am - 9:20 am
"Nucleotide Deamination by the RADAR Supramolecular Anti-Phage Defense Complex"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
"tRNAslational Control of Eukaryotic Gene Expression"
9:45 am - 9:50 am
Discussion
9:50 am - 10:00 am
"Comprehensive Prediction of dsRNA Formation and Distribution in the Human Genome"
10:00 am - 10:05 am
Discussion
10:05 am - 10:35 am
Coffee Break
10:35 am - 10:55 am
"Dual C-to-U and U-to-C Base Editing Mechanisms By DYW Enzymes"
10:55 am - 11:00 am
Discussion
11:00 am - 11:20 am
"rRNA 2'-O-Methylation Modulates Ribosome Structure and Biogenesis Assembly"
11:20 am - 11:25 am
Discussion
11:25 am - 11:45 am
"Monitoring tRNA Splicing and Nucleotide Chemical Modification by Nuclear Magnetic Resonance"
11:45 am - 11:50 am
Discussion
11:50 am - 12:10 pm
"Structural Insights into Substrate Binding and Editing Specificity by ADAR2"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
RNA Editing and Modifications in Infectious Organisms and Their Hosts
6:00 pm - 6:20 pm
"The magic of ADAR proteins"
6:20 pm - 6:25 pm
Discussion
6:25 pm - 6:45 pm
"RNA Modifications at the Virus-Host Interface"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:10 pm
"Epitranscriptomics and Beyond: The Importance of Modification Enzymes in Response to Stress in Vibrio cholerae "
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:35 pm
"tRNA Hypomodification Facilitates Antifungal Drug Resistance in Aspergillus fumigatus "
7:35 pm - 7:40 pm
Discussion
7:40 pm - 7:50 pm
"Decoding the tRNA Epitranscriptome and Its Role in Pseudomonas aeruginosa Pathogenicity"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Therapeutic Applications Using RNA Editing and Modifications
9:00 am - 9:20 am
"Functional Mapping and Modulation of ADAR Activity for Cellular Engineering"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
"Optimizing LEAPER for Enhanced Versatility and Precision in RNA Editing"
9:45 am - 9:50 am
Discussion
9:50 am - 10:00 am
"A Versatile High-Throughput Platform for Epitranscriptomic Drug Discovery"
10:00 am - 10:05 am
Discussion
10:05 am - 10:15 am
"Employment of nanoVAST-gRNA for Efficient Intracellular Delivery of Therapeutic cargos"
10:15 am - 10:20 am
Discussion
10:20 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Programmable Pseudouridylation to Suppress Nonsense Mutations"
11:05 am - 11:10 am
Discussion
11:10 am - 11:30 am
"Developing Axiomerâ„¢ RNA Editing Technology Towards Application in Liver and CNS Disease"
11:30 am - 11:35 am
Discussion
11:35 am - 11:45 am
"Leveraging Purified Human ADARs to Elucidate Oligonucleotide-Directed RNA Editing Kinetics and Predict In Vivo Outcomes"
11:45 am - 11:50 am
Discussion
11:50 am - 12:00 pm
"Key Factors for Precise and Efficient RNA Base Editing in the CNS"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:25 pm
"Large Language Models for RNA Editing Prediction"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Keynote Session: New Tools Using RNA Editing and Modifications
6:00 pm - 6:30 pm
"Structure-Activity Relationships in ADAR Reactions"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
"Molecular Architectures of RNA-Modifying Ribozymes"
7:00 pm - 7:05 pm
Discussion
7:05 pm - 7:25 pm
"Targeted RNA Base Editing with Endogenous ADAR"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"RNA Programmable Cell Editing"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure