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RNA Nanotechnology (GRS)

Gordon Research Seminar

New Frontiers in RNA Nanotechnology-Based Therapeutics and Diagnostics

January 12 - 13, 2019

Chairs

and

Four Points Sheraton / Holiday Inn Express

1050 Schooner Drive

Ventura, California, United States

Venue and Travel Information

Conference Description

This Gordon Research Seminar (GRS) brings together early-career scientists from graduate students to junior faculty members in the field of RNA nanotechnology. The seminar offers participants an exceptional environment to discuss their latest research, exchange ideas, initiate collaborations, and network with peers.

The 2019 RNA Nanotechnology Gordon Research Seminar will focus on four pillars of RNA nanotechnology: structure, diagnostics, therapeutics, and delivery. RNA nanotechnology is promising for the development of new therapeutic and diagnostic strategies for life-threatening diseases. Topics that will be covered in keynote, oral, and poster presentations include RNA structural studies, RNA-based sensors, RNA therapeutics, delivery vehicles, and extracellular vesicles. In particular, the seminar will focus on the unique challenges and benefits of RNA nanotechnology.

Related Meeting

This GRS will be held in conjunction with the "RNA Nanotechnology" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
2:00 pm - 5:00 pm	Arrival and Check-in
3:30 pm - 3:45 pm	Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm	Keynote Session: Immunogenicity of RNA Nanoparticles Discussion Leader:
3:45 pm - 4:10 pm	"Immunomodulation in RNA Nanotechnology"
4:10 pm - 4:15 pm	Discussion
4:15 pm - 4:25 pm	"Understanding Immunogenic Properties of Nucleic Acid Nanoparticles"
4:25 pm - 4:30 pm	Discussion
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Therapeutic and Diagnostic Applications of RNA Nanoparticles Discussion Leader:
7:30 pm - 7:40 pm	"Photo-Controlled Release of Paclitaxel and Model Drugs from RNA Pyramids"
7:40 pm - 7:45 pm	Discussion
7:45 pm - 7:55 pm	"RNA-DNA Fibers and Polygons with Controlled Immunogenicity Can Activate RNAi and Transcriptional Regulation of NF-kB"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 8:10 pm	"Arrowtail RNA for Ligand Display on Ginger Exosome-Like Nanovesicles to Systemic Deliver siRNA for Cancer Suppression"
8:10 pm - 8:15 pm	Discussion
8:15 pm - 8:25 pm	"Screening, Selection and Characterization of Aptamers Against Ovarian Cancer Biomarker CA125"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:40 pm	"Bioresponsive Quantum Dot Lattices for Applications in Biosensing and Conditionally Activated RNA Interference"
8:40 pm - 8:45 pm	Discussion
8:45 pm - 8:55 pm	"Universal Synthetic Technique of Nucleic Acid-Based Nanodetectors and Carrier-Free siRNA Delivery System"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	"PTex: A Rapid and Unbiased Method for Cell-Wide Purification of Crosslinked RNA-Protein Complexes in Human and Bacteria"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	"Rapid, Affordable, Ultra-Sensitive Food Pathogen Biosensor, with Emphasis on Industrial Applicability"
9:25 pm - 9:30 pm	Discussion
Sunday
7:30 am - 8:30 am	Breakfast
9:00 am - 11:00 am	Structural RNA Studies Discussion Leader:
9:00 am - 9:10 am	"Metal Nanoparticles Capped with Structured RNA: The Spherical Incarnation of TectoRNA"
9:10 am - 9:15 am	Discussion
9:15 am - 9:25 am	"Palladacyclic Conjugate Group Promotes Hybridization of Short Oligonucleotides"
9:25 am - 9:30 am	Discussion
9:30 am - 9:40 am	"Comprehensive and Consistent Identification, Annotation, Extraction and Classification of RNA Multi-Helix Junction (MHJ) for Use in Nanotechnology Applications"
9:40 am - 9:45 am	Discussion
9:45 am - 9:55 am	"Cryo-EM Structure of Type III-A CRISPR-Cas Csm Complex"
9:55 am - 10:00 am	Discussion
10:00 am - 10:10 am	"Effects of RNA Nanoparticle Size, Shape, Structure, Sequence and Surface Chemistry on Biodistribution, Immunogenicity and Endosome Escape"
10:10 am - 10:15 am	Discussion
10:15 am - 10:25 am	"A DNA Origami Platform for RNA Tertiary Structure Elucidation"
10:25 am - 10:30 am	Discussion
10:30 am - 10:40 am	"Walk on the Origami Side: From Switchable DNA Nanodevices to Light-up Bio-Orthogonal RNA Nanoribbon"
10:40 am - 10:45 am	Discussion
10:45 am - 10:55 am	"Expanding the Design Space of DNA Origami with Functional and Orthogonal Custom Scaffolds"
10:55 am - 11:00 am	Discussion
11:00 am - 12:30 pm	Poster Session Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm	Lunch
1:30 pm - 2:30 pm	Mentorship Component: Career Panel This panel consists of laboratory leaders, research center directors, and industry scientists. Discussion Leader:
1:30 pm - 2:30 pm	Panel Discussion Career Advice from Leaders in the Field
2:30 pm - 3:00 pm	Evaluation Period Fill in GRS Evaluation Forms
3:00 pm	Seminar Concludes

Contributors

Funding for this conference was made possible (in part) by 1R13TR002708-01 from the National Center for Advancing Translational Sciences (NCATS) or the Office of Research Infrastructure Programs (ORIP). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

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Conference History RNA Nanotechnology

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