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RNA Nanotechnology (GRS)

Gordon Research Seminar

Delivery, Design and Function of RNA Nanostructures

January 7 - 8, 2023

Chairs

and

Four Points Sheraton / Holiday Inn Express

1050 Schooner Drive

Ventura, California, United States

Venue and Travel Information

Conference Description

The RNA Nanotechnology GRS provides a unique forum for young doctoral and post-doctoral researchers to present their work, discuss new methods, cutting edge ideas, and pre-published data, as well as to build collaborative relationships with their peers. Experienced mentors and trainee moderators will facilitate active participation in scientific discussion to allow all attendees to be engaged participants rather than spectators.

The 2023 GRS will focus on major areas pertaining to the design of RNA into rationally designed nanostructures. Sessions will follow the developmental pipeline from computational and structural design to use in applications as diagnostics, therapeutics, and materials. Challenges facing the field, including the cellular delivery of these formulations and the immune stimulation of nucleic acid-based nanostructures, will also be explored. The schedule will include talks on research findings as well as poster presentations to drive discussion on these topics and beyond.

Related Meeting

This GRS will be held in conjunction with the "RNA Nanotechnology" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
1:00 pm - 5:00 pm	Arrival and Check-in
3:30 pm - 3:45 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm	Keynote Session: Functional Nucleic Acid Nanoparticles Discussion Leader:
3:45 pm - 4:10 pm	"Functional Nucleic Acid Nanoparticles"
4:10 pm - 4:15 pm	Discussion
4:15 pm - 4:25 pm	"Cotranscriptionally Encoded RNA Strand Displacement Circuits for Engineering Biology"
4:25 pm - 4:30 pm	Discussion
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Computational, Structural, and Mechanistic Studies of Nucleic Acids Discussion Leaders:
7:30 pm - 7:40 pm	"Co-transcriptionally Folded RNA Origami and DNA Stack Memory as Potential Interfaces Able to Operate In Vivo"
7:40 pm - 7:45 pm	Discussion
7:45 pm - 7:55 pm	"SAXS for NANPs: Advancing the Structural Characterization of Nucleic Acid Nanoparticles Through Small-angle X-ray Scattering"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 8:10 pm	"In Vitro Evolution with Rationally-Designed RNA Library: Generation of Smallest Trans-Acting Ligase Ribozyme that Enables RNA Concatenation"
8:10 pm - 8:15 pm	Discussion
8:15 pm - 8:25 pm	"Unsupervised Voxel-based Segmentation reveals a Landscape of Bacterial Ribosome Large Subunit Early Assembly"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:40 pm	"Engineering DNA Liquids for Macroscopic Separation of Biomolecules"
8:40 pm - 8:45 pm	Discussion
8:45 pm - 8:55 pm	"Expression Platform Features Tune Functional Characteristics of the Clostridium beijerinckii ZTP Riboswitch"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	"Deducing RNA Structure and Dynamics from Quantitative Analysis of Chemical Probing Reactivities"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	"Engineering DNA Droplet-Droplet Signaling via Transcription"
9:25 pm - 9:30 pm	Discussion
Sunday
7:30 am - 8:30 am	Breakfast
9:00 am - 11:00 am	RNA Nanomaterials in Therapy and Medicine Discussion Leaders:
9:00 am - 9:10 am	"mRNA and Peptide Amphiphile Nanofibers"
9:10 am - 9:15 am	Discussion
9:15 am - 9:25 am	"Functionalizing Nucleic Acid Nanoparticles for the Delivery of Nucleic Acid Therapeutics"
9:25 am - 9:30 am	Discussion
9:30 am - 9:40 am	"Development of an Aptamer Based Sensor for Point of Care Monitoring of Antiretroviral Therapy"
9:40 am - 9:45 am	Discussion
9:45 am - 9:55 am	"Role of the Type 1 Interferon Response in Humoral Immunity Elicited by Self-Replicating RNA Vaccines"
9:55 am - 10:00 am	Discussion
10:00 am - 10:10 am	"A DNA-scaffolded Vaccine Platform for Programmable Presentation of Engineered HIV Immunogens"
10:10 am - 10:15 am	Discussion
10:15 am - 10:25 am	"Engineering Reusable Synthetic RNA Strand Displacement Circuits"
10:25 am - 10:30 am	Discussion
10:30 am - 10:40 am	"3D RNA-Scaffolded Wireframe Origami"
10:40 am - 10:45 am	Discussion
10:45 am - 10:55 am	"Genetically Encoded Fluorogenic RNA-based Bioluminescence Resonance Energy Transfer (BRET) Sensors for Cellular Imaging and Target Detection"
10:55 am - 11:00 am	Discussion
11:00 am - 12:30 pm	Poster Session Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm	Lunch
1:30 pm - 2:30 pm	Mentorship Component: The Next Generation of RNA Therapeutics Discussion Leader:
1:30 pm - 2:30 pm	Panel Discussion The Next Generation of RNA Therapeutics
2:30 pm - 3:00 pm	Evaluation Period Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm	Seminar Concludes

Contributors

Research reported in this publication was supported by the National Cancer Institute and the National Center for Advancing Translational Sciences of the National Institutes of Health under Award Number R13CA277856. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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Conference History RNA Nanotechnology

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