| FRIDAY, JUNE 12
|
| 6:00 - 7:00 |
Dinner |
| 7:15 |
Opening Remarks
J. Corbin |
| Discussion Leader: Vincent Manganiello (National Institutes of Health) |
| 7:30 |
A cAMP phosphodiesterase with a response regulator domain controls PKA activity in Dictyostelium
William Loomis, University of California at San Diego |
| 7:55 |
Leptin signaling through activation of PDE3B
Allan Zhao, University of Washington |
| 8:20 |
Phosphorylation/activation of Phosphodiesterase 3B in adipocytes-role in antilipolysis
Eva Degerman, University of Lund, Sweden |
| 8:45 |
Structural elements important in association of PDE3 with intracellular membranes
Vincent Manganiello, National Institutes of Health |
| 9:10 |
Break |
| 9:25 |
cGMP regulates platelet function through the balance of its actions on PDE3 and PDE2
Richard Haslam, McMaster University, Canada |
| 9:50 |
Regulation of PDEs by phosphatidic acid
Georges Nemoz, Inserm |
| 10:05 |
End session |
| SATURDAY, JUNE 13 |
| 7:30 - 8:30 |
Breakfast |
|
Discussion Leader: Marco Conti (Stanford University) |
| 9:00 |
Insights into mechanisms which determine changes in the sensitivity of specific PDE4 isoforms to inhibition by rolipram
Miles Houslay, University of Glasgow, Scotland, United Kingdom |
| 9:25 |
Molecular basis and biological significance of PDE4 conformers
Theodore Torphy, SmithKline Beecham Pharmaceuticals |
| 9:50 |
Regulatory consequences of PDE4 isoform diversity
Graeme Bolger, University of Utah |
| 10:15 |
The PDE4D gene and its protein products: role in cAMP homeostasis
Marco Conti, Stanford University |
| 10:40 |
Break |
| 10:55 |
"Divalent ion effects and insights into the ligand binding mechanism of type 4 phosphodiesterase"
Zheng Huang, Merck Frosst, Canada |
| 11:10 |
Regulation of activity of the cAMP-specific PDE4D enzymes
Eric Ball, University of Western Ontario, Canada |
| 11:35 |
Amino acids in the catalytic domain of cAMP phosphodiesterases
Robert Colman, Temple University |
| 12:00 |
Pharmacological specificity determinants in a PDE4 isozyme
John Colicelli, UCLA |
| 12:15 |
End session |
| 12:30 - 1:30 |
Lunch |
| 4:00 - 6:00 |
Poster Session |
| 6:00 - 7:00 |
Dinner |
|
Discussion Leader: Sam Strada (University of South Alabama)
|
| 7:30 |
The nitric oxide/cGMP signal transduction system is developmentally regulated in the lung
Lucienne Sanchez, Harvard University |
| 7:55 |
The mechanism of action of sildenafil (VIAGRA®), a selective inhibitor of cGMP-specific PDE5 for the treatment of male erectile dysfunction
Stephen Ballard, Pfizer Central Research, England, United Kingdom |
| 8:20 |
Regulation of cGMP phosphodiesterases by small molecular mass proteins related to the rod photoreceptor inhibitor protein
Nigel Pyne, University of Strathclyde, England, United Kingdom |
| 8:45 |
PDE5 catalytic domain
Sharron Francis, Vanderbilt University |
| 9:10 |
Break |
| 9:25 |
Site-directed mutagenesis of PDE5
Jackie Corbin, Vanderbilt University |
| 9:50 |
cGMP binding to membrane-bound PDE6
Rick Cote, University of New Hampshire |
| 10:05 |
End Session |
| SUNDAY, JUNE 14 |
| 7:30 - 8:30 |
Breakfast |
|
Discussion Leader: Joe Beavo (University of Washington) |
| 9:00 |
PDE6: structure, function and regulation
Nikolai Artemyev, University of Iowa |
9:25 |
[title to be announced]
Kate Loughney, ICOS Corporation |
| 9:50 |
PDE4 and vasomodulation
Claire Lugnier, University of Strasbourg |
| 10:15 |
[title to be announced]
Joe Beavo, University of Washington |
| 10:40 |
Break |
10:55 |
Short Talk
Paul Epstein, University of Connecticut |
| 11:10 |
Regulation of PDE7
Tamar Michaeli, Albert Einstein College of Medicine |
| 11:35 |
Human PDE7
Ray Owens, Celltech Therapeutics |
| 11:50 |
Short Talk
[speaker to be announced] |
| 12:15 |
End Session |
| 12:05 - 1:00 |
Sack Lunches / Bus Leaves |
