Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Keynote Session: Dissecting and Overcoming Cancer Immune Evasion
3:45 pm - 4:20 pm
"Dissecting and Overcoming Cancer Immune Evasion"
4:20 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cellular States, Evolution, and Tumor Ecosystems
7:30 pm - 7:40 pm
"Pre-Existing Non-Genetic Cellular States Determine Susceptibility to Oncogenic Transformation"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Cell State Plasticity Emerging From Co-Regulated, Competitive, and Configurable Interactions within the AP-1 Network"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
"Identifying the Microenvironmental Drivers of AP-1 Mediated Differentiation State Heterogeneity in Primary Melanoma Tissues"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
"Multiomic Single-Cell Profiling of A Novel MYC-Driven Mouse Prostate Cancer Model"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Single-Molecule Resolution Spatial Transcriptomics Analyses of Colorectal Cancer Reveal Broad Epigenetic Regulation Linked with Necrosis"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Circadian Dynamics of the Tumor Microenvironment in Triple Negative Breast Cancer at Single-Cell Resolution"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Decoding the Tumor Ecosystem Using Single Nuclei Analysis Identifies Common Transcriptional Programs and Therapeutic Vulnerabilities in Peripheral T-Cell Lymphomas"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"IL-15 Enhances Innate Lymphoid Cell-Mediated Anti-Tumor Immunity in Brain Metastasis"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Emerging Tools to Decode Cancer Complexity
9:00 am - 9:10 am
"BARTsc: Motif-Independent Identification of Functional Transcription Factors From Single-Cell Multiomics Data"
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
"Resolving Methylation Dynamics Underlying Normal and Altered Hematopoiesis Using Scalable Single Methylation Sequencing"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
"Paired Cell Images and scRNA-seq Facilitates Continuous Transcriptomic State Inference from Images During Cell State Transition in EMT"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
"BESTish: A Diffusion-Approximation Framework for Inferring Selection and Mutation in Clonal Hematopoiesis"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Discovery of Functional Hypermutated Super-Enhancer Hotspots Across DLBCL Oncogenes Using Deep Learning–Based In Silico Mutagenesis"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"In Situ Inference of Copy Number Variations in Image-Based Spatial Transcriptomics"
10:25 am - 10:30 am
Discussion
10:30 am - 10:40 am
"ScLiTevo - An Evolutionary Computational Framework for Detecting Cell State Dynamics from Single-Cell Lineage-Traced Data"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
"CellTrails: Connecting Prior Cell-Cell Interactions with Current Spatial Locations and Gene Expression"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Perspectives on the Future of Single-Cell Cancer Biology
1:30 pm - 2:30 pm
Panel Discussion
Shaping the Future of Single-Cell Cancer Biology
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes