| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:25 pm | Staphylococcal Diseases GRC: Past And Present |
| 7:40 pm - 7:45 pm | Discussion Leader: Vance G. Fowler (Duke University)
"Introductory remarks"
|
| 7:45 pm - 8:15 pm | Georg Peters (University of Muenster)
"Staphylococcal Diseases GRC: 1989 - 2013"
|
| 8:15 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Michael Olson (University of Iowa)
"The Staphylococcal Diseases GRS: 2013 and Beyond"
|
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:15 pm | Selected from GRS: Alison Murphy (Trinity College, Dublin)
"Exposure to Staphylococcus aureus expands a population of gamma delta T-cells that are protective during subsequent infection"
|
| 9:15 pm - 9:25 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | In the Center of It All: Metabolic Determinants of Virulence |
| 9:00 am - 9:10 am | Discussion Leader: Anthony Richardson (University of North Carolina)
"Introduction"
|
| 9:10 am - 9:40 am | Charles Rock (St. Jude Children's Hospital)
"Membrane lipid synthesis in Staphylococcus aureus"
|
| 9:40 am - 9:50 am | Discussion |
| 9:50 am - 10:05 am | Neil Reiner (University of British Columbia)
"Targeting pyruvate kinase in Staphylococcus aureus"
|
| 10:05 am - 10:10 am | Discussion |
| 10:10 am - 10:45 am | Group Photo / Coffee Break |
| 10:45 am - 11:15 am | Linc Sonenshein (Tufts University School of Medicine)
"Interactions between metabolism and virulence" |
| 11:15 am - 11:25 am | Discussion |
| 11:25 am - 11:40 am | Selected from GRS: Mark J. White (University of Iowa)
"SrrAB-regulated PI-PLC is important for survival of Staphylococcus aureus USA300 in human blood and neutrophils"
|
| 11:40 am - 11:45 am | Discussion |
| 11:45 am - 12:15 pm | Eric Skaar (Vanderbilt University)
"Probing central metabolism using chemical genetics uncovers new therapeutic targets"
|
| 12:15 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | The Flexible Genome and Its Impact on All Things Staphylococcal |
| 7:30 pm - 7:35 pm | Discussion Leader: Sharon Peacock (University of Cambridge)
"Introduction" |
| 7:35 pm - 8:05 pm | Steven Tong (Charles Darwin University)
"Phenotype and genomics of Staphylococcus aureus CC75"
|
| 8:05 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:30 pm | Anne Catrin Uhlemann (Columbia University)
"Insights into carriage and USA300"
|
| 8:30 pm - 8:35 pm | Discussion |
| 8:35 pm - 9:05 pm | Matt Holden (Wellcome Trust Sanger Institute, Cambridge)
"Genomic evidence of microevolution in Staphylococcus aureus"
|
| 9:05 pm - 9:10 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | The Staphylococcal Circuit Board: Keeping The Virulence Flowing |
| 9:00 am - 9:10 am | Discussion Leader: Brice Felden (University of Rennes)
"Introduction"
|
| 9:10 am - 9:40 am | Inigo Lasa (University of Navarra)
"Staphylococcus aureus transcriptome and beyond"
|
| 9:40 am - 9:50 am | Discussion |
| 9:50 am - 10:05 am | Svetlana Chabeskaya (Université de Rennes)
"Regulatory RNAs promoting Staphylococcus aureus immune escape"
|
| 10:05 am - 10:10 am | Discussion |
| 10:10 am - 10:45 am | Coffee Break |
| 10:45 am - 11:15 am | Ambrose Cheung (Dartmouth Medical College)
"Contribution of teg49 sRNA to virulence in Staphylococcus aureus"
|
| 11:15 am - 11:25 am | Discussion |
| 11:25 am - 11:40 am | Selected from GRS: James Cassat (Vanderbilt Medical Center)
"Identification of bacterial factors contributing to pathologic bone remodeling during S. aureus osteomyelitis"
|
| 11:40 am - 11:45 am | Discussion |
| 11:45 am - 12:15 pm | Tarek Msadek (Institut Pasteur)
"A very well hidden talent: natural competence for DNA uptake in Staphylococcus aureus"
|
| 12:15 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Alternative Lifestyles of the Staphylococci |
| 7:30 pm - 7:40 pm | Discussion Leader: Kelly Rice (University of Florida)
"Introduction"
|
| 7:40 pm - 8:10 pm | Bettina Loffler (University Hospital of Münster)
"Bacterial phenotype switching and intracellular persistence as cause for chronic infections" |
| 8:10 pm - 8:20 pm | Discussion |
| 8:20 pm - 8:40 pm | Mark Shirtliff (University of Maryland-Baltimore County)
"A pentavalent vaccine against Staphylococcus aureus planktonic and biofilm infections" |
| 8:40 pm - 8:45 pm | Discussion |
| 8:45 pm - 9:15 pm | Tammy Kielian (University of Nebraska Medical Center)
"In vivo models to investigate the interplay between Staphylococcus aureus biofilms and host innate immunity"
|
| 9:15 pm - 9:25 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Antibacterial Strategies |
| 9:00 am - 9:10 am | Discussion Leader: Michael Yeaman (University of California Los Angeles)
"Introduction" |
| 9:10 am - 9:40 am | Victor Nizet (University of California-San Diego)
"Novel 'outside-the-box' approaches to MRSA"
|
| 9:40 am - 9:50 am | Discussion |
| 9:50 am - 10:10 am | Annaliesa S. Anderson (Pfizer)
"Vaccine development by harnessing the immunopathogenic mechanisms of S. aureus" |
| 10:10 am - 10:15 am | Discussion |
| 10:15 am - 10:45 am | Coffee Break |
| 10:45 am - 11:15 am | Paul Dunman (University of Rochester Medical Center)
"Antibiotic development-targeting Staphylococcus aureus RnpA" |
| 11:15 am - 11:25 am | Discussion |
| 11:25 am - 11:40 am | Chip Chambers (University of California-San Francisco)
"Preliminary Analysis of a Randomized Double Blind Multicenter Trial of Clindamycin versus TMP/SMX for Uncomplicated Skin and Soft Tissue Infections" |
| 11:40 am - 11:45 am | Discussion |
| 11:45 am - 12:15 pm | Fabio Bagnoli (Novartis, Sienna, Italy)
"A vaccine targeting major toxicity and virulence factors generates broad protection against different Staphylococcus aureus disease outcomes"
|
| 12:15 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session II |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
| 7:30 pm - 9:30 pm | The Animalistic Nature of The Beast: The Staphylococci as Zoonotic Pathogens |
| 7:30 pm - 7:40 pm | Discussion Leader: George Stewart
"Introduction"
|
| 7:40 pm - 8:10 pm | Ross Fitzgerald (University of Edinburgh)
"Staphylococcus aureus at the human-livestock interface"
|
| 8:10 pm - 8:20 pm | Discussion |
| 8:20 pm - 8:35 pm | Robert Skov (Statens Serum Institut)
"MRSA as a zoonotic pathogen"
|
| 8:35 pm - 8:40 pm | Discussion |
| 8:40 pm - 9:10 pm | Jose Penades (Instituto de Biomedicine de Valencia)
"Mechanism of host adaptation in S. aureus"
|
| 9:10 pm - 9:15 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | The Other Side of the Equation: The Host Response to Staphylococcal Infection |
| 9:00 am - 9:10 am | Discussion Leader: Rachel McLoughlin (Trinity College)
"Introduction" |
| 9:10 am - 9:40 am | Lloyd Miller (John's Hopkins University)
"Innate immune mechanisms that promote neutrophil recruitment against cutaneous Staphylococcus aureus infection"
|
| 9:40 am - 9:50 am | Discussion |
| 9:50 am - 10:05 am | Eva Medina (Helmholtz Centre for Infection)
"The immune response to Staphylococcus aureus: a tale of whoa and woe"
|
| 10:05 am - 10:10 am | Discussion |
| 10:10 am - 10:45 am | Coffee Break |
| 10:45 am - 11:15 am | Jovanka Voyich (Montana State University)
"The Staphylococcus aureus SaeR/S system: Triggering inflammation in the host"
|
| 11:15 am - 11:25 am | Discussion |
| 11:25 am - 11:40 am | Selected from GRS: Frances Alonzo (NYU Medical Center)
"Leukocidin immune cell targeting: Unveiling determinants of cellular specificity"
|
| 11:40 am - 11:45 am | Discussion |
| 11:45 am - 12:15 pm | Julia Wardenburg (University of Chicago) |
| 12:15 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session II |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Poster Review |
| 7:30 pm - 7:35 pm | Discussion Leader: Magnus Hook (Texas A&M Health Science Center)
"Introduction" |
| 7:35 pm - 7:45 pm | Meera Unnikrishnan (Norvartis)
"The staphylococcal Esx proteins modulate host cell apoptosis"
|
| 7:45 pm - 7:50 pm | Discussion |
| 7:50 pm - 8:00 pm | Jorge Garcia-Lara (University of Sheffield)
"Supramolecular architecture of the Staphylococcus aureus membrane"
|
| 8:00 pm - 8:05 pm | Discussion |
| 8:05 pm - 8:15 pm | Som Chatterjee (NIAID/NIH)
"Essential Staphylococcus aureus toxin export system"
|
| 8:15 pm - 8:20 pm | Discussion |
| 8:20 pm - 8:30 pm | Sunje Pamp (Stanford University)
"Interactions of Staphylococcus aureus with the indigenous microbiota"
|
| 8:30 pm - 8:35 pm | Discussion |
| 8:35 pm - 8:45 pm | Julia Kolata (University of Greifswald)
"The human T cell response to Staphylococcus aureus"
|
| 8:45 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:00 pm | Andras Spaan (Utrecht Medical Centre)
"Identification of staphylococcal hemolysin-gamma receptors"
|
| 9:00 pm - 9:05 pm | Discussion |
| 9:05 pm - 9:15 pm | Wilmara Salgado-Pabon (University of Iowa)
"Superantigens are critical for Staphylococcus aureus endocarditis in rabbits"
|
| 9:15 pm - 9:20 pm | Discussion |
| 9:20 pm - 9:30 pm | Concluding Remarks |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |